Depot- and Gender-related Differences in the Lipolytic Pathway of Adipose Tissue from Severely Obese Patients
Abstract
The present study was performed to analyze in detail gender- and site-related alterations in the adrenergic signal transduction pathway of lipolysis in fat cells isolated from subcutaneous abdominal and visceral fat depots from severely obese patients. The study group consisted of 30 morbidly obese subjects (9 men and 21 women) aged 41.1+/-1.9 years, with a body mass index (BMI) of 54.7+/-1.7 kg/m2, who had undergone abdominal surgery. Protein levels of hormone-sensitive lipase (HSL) and adrenergic receptors (AR), as well as HSL activity and the lipolytic response to adrenergic agents were analyzed. Both fat depots had similar basal lipolysis, but the capacity of catecholamines to activate lipolysis was greater in visceral fat, both at AR and postreceptor levels. Basal lipolysis and lipolytic activity induced by dibutyryl cyclic AMP were higher in men than in women. However, the visceral depot of women showed a higher maximal stimulation by noradrenaline than that of men, in accordance with higher beta1- and beta3-AR protein levels. In conclusion, the main gender-related differences were located in the visceral depot, with women exhibiting a higher sensitivity to catecholamines associated with an increased provision of beta-AR, while men showed an enhanced lipolytic capacity at the postreceptor level.
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β1 and β3 adrenergic receptor protein levels in omental fat are greater in women than in men.
“It has been reported that β−1 and β−3 adrenergic receptor protein levels in omental fat are greater in women than men (54)”
From Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans (2025) · cites this paper as [54]
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Metabolism of Isolated Fat Cells
Rodbell, M. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51687-2 · Cited by 4,647 · see citing works
Fat Mobilization in Adipose Tissue Is Promoted by Adipose Triglyceride Lipase
Zimmermann, R., Bogner‐Strauß, J. G., Haemmerle, G., Schoiswohl, G., Birner‐Gruenberger, R., Riederer, M., Lass, A., Neuberger, G., Eisenhaber, F., Hermetter, A., et al. (2004) · Science · doi:10.1126/science.1100747 · Cited by 2,121 · see citing works
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909 · see citing works
Fitting curves to data using nonlinear regression: a practical and nonmathematical review
Motulsky, H. J., & Ransnas, L. A. (1987) · The FASEB Journal · doi:10.1096/fasebj.1.5.3315805 · Cited by 1,327 · see citing works
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132 · see citing works
Fat cell adrenergic receptors and the control of white and brown fat cell function
Lafontan, M., & Berlan, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37695-1 · Cited by 636 · see citing works
Scopinaro, N., Adami, G., Marinari, G. M., Gianetta, E., Traverso, E., Friedman, D., Camerini, G. B., Baschieri, G., & Simonelli, A. (1998) · World Journal of Surgery · doi:10.1007/s002689900497 · Cited by 553 · see citing works
Body fat distribution, insulin resistance, and metabolic diseases
Björntorp, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00191-3 · Cited by 470 · see citing works
Differences in Lipolysis between Human Subcutaneous and Omental Adipose Tissues
Arner, P. (1995) · Annals of Medicine · doi:10.3109/07853899709002451 · Cited by 448 · see citing works
Expression, regulation, and triglyceride hydrolase activity of Adiponutrin family members
Lake, A. C., Sun, Y., Li, J., Kim, J. E., Johnson, J., Li, D., Revett, T., Shih, H. H., Liu, W., Paulsen, J. E., et al. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500290-jlr200 · Cited by 294 · see citing works
Hormone-sensitive lipase - new roles for an old enzyme
Yeaman, S. J. (2004) · Biochemical Journal · doi:10.1042/bj20031811 · Cited by 262 · see citing works
Large, V., Reynisdottir, S., Langin, D., Fredby, K., Klannemark, M., Holm, C., & Arner, P. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32429-9 · Cited by 228 · see citing works
Williams, C. M. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2003314 · Cited by 211 · see citing works
Catecholamine-induced lipolysis in obesity
Arner, P. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800789 · Cited by 196 · see citing works
van Harmelen, V., Dicker, A., Rydén, M., Hauner, H., Lönnqvist, F., Näslund, E. B., & Arner, P. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2029 · Cited by 188 · see citing works
Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells.
Hellmér, J., Marcus, C., SONNENFELD, T., & Arner, P. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.1.1320047 · Cited by 184 · see citing works
Sex Differences in Visceral Fat Lipolysis and Metabolic Complications of Obesity
Lönnqvist, F., Thörne, A., Large, V., & Arner, P. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1472 · Cited by 158 · see citing works
Adrenergic regulation of adipocyte metabolism
Lafontan, M., Barbe, P., Galitzky, J., Tavernier, G., Langin, D., Carpéné, C., Bousquet‐mélou, A., & Berlan, M. (1997) · Human Reproduction · doi:10.1093/humrep/12.suppl_1.6 · Cited by 130 · see citing works
Hoffstedt, J., Arner, P., Hellers, G., & Lönnqvist, F. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37246-1 · Cited by 129 · see citing works
Comparison of Hormone-Sensitive Lipase Activity in Visceral and Subcutaneous Human Adipose Tissue1
Reynisdottir, S., Dauzats, M., Thörne, A., & Langin, D. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4427 · Cited by 112 · see citing works
Effect of cell size on lipolysis and antilipolytic action of insulin in human fat cells
Jacobsson, B., & Smith, U. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39370-6 · Cited by 111 · see citing works
Bulló, M., García‐Lorda, P., Peinado‐Onsurbe, J., Hernández, M., Castillo, D. D., Argilés, J. M. A., & Salas‐Salvadó, J. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801977 · Cited by 101 · see citing works
Kraemer, F. B., Patel, S., Saedi, M., et al. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39990-9 · Cited by 92 · see citing works
van Harmelen, V., Lönnqvist, F., Thörne, A., et al. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800504 · Cited by 90 · see citing works
Löfgren, P., Hoffstedt, J., Rydén, M., Thörne, A., Holm, C., Wahrenberg, H., & Arner, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8254 · Cited by 64 · see citing works
Puigserver, P., Lladó, I., Palou, A., & Gianotti, M. (1991) · Biochemical Journal · doi:10.1042/bj2790575 · Cited by 53 · see citing works
Self-citationGender effects on adrenergic receptor expression and lipolysis in white adipose tissue of rats.
Lladó, I., Rodriguez-Cuenca, S., Pujol, E., Monjo, M., Estrany, M., Roca, P., & Palou, A. (2002) · Obesity Research · doi:10.1038/oby.2002.41 · Cited by 53 · see citing works
Self-citationKolehmainen, M., Vidal, H., Ohisalo, J., Pirinen, E., Alhava, E., & Uusitupa, M. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0801858 · Cited by 46 · see citing works
A new lipase in regulating lipid mobilization: hormone-sensitive lipase is not alone
Raben, D. M., & Baldassare, J. J. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.01.009 · Cited by 44 · see citing works
Genetic variance and lipolysis regulation: implications for obesity
Arner, P. (2001) · Annals of Medicine · doi:10.3109/07853890108995964 · Cited by 43 · see citing works
Lladó, I., Estrany, M. E., Rodríguez, E., Amengual, B., Roca, P., & Palou, A. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801390 · Cited by 32 · see citing works
Self-citationGender- and site-related effects on lipolytic capacity of rat white adipose tissue
Pujol, E., Rodr�guez-Cuenca, S., Frontera, M., Justo, R., Llad�, I., Kraemer, F. B., Gianotti, M., & Roca, P. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3125-5 · Cited by 24 · see citing works
Self-citationRay, H., Beylot, M., Arner, P., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1417 · Cited by 20 · see citing works
Ramis, J. M., Bibiloni, B., Moreiro, J., García-Sanz, J. M., Salinas, R., Proenza, A. M., & Lladó, I. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.12.009 · Cited by 18 · see citing works
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Estrogens in adipose tissue physiology and obesity-related dysfunction
Kuryłowicz, A. (2023) · Biomedicines · doi:10.3390/biomedicines11030690 · Cited by 178 · see citing works
Phillips, C. L., Yee, B. J., Trenell, M. I., Magnussen, J. S., Wang, D., Banerjee, D., Berend, N., & Grunstein, R. R. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27595 · Cited by 46 · see citing works
Costa, D. N., Santosa, S., & Jensen, M. D. (2025) · Physiological Reviews · doi:10.1152/physrev.00008.2024 · Cited by 34 · see citing works
- Authors
- Ramis, J. M., Salinas, R., García-Sanz, J. M., Moreiro, J., Proenza, A. M., & Lladó, I.
- Affiliations
- Hospital Universitario Son Dureta (ES)
- Research Institute of Health Sciences (ES)
- Venue
- Cellular Physiology and Biochemistry
- Publisher
- S. Karger AG
- Published
- 2006
- Volume
- 17
- Issue
- 3-4
- Pages
- 173-180
- ISSN
- 1015-8987 (ISSN-L)
- 1421-9778
- OpenAlex
- W1971174667
- Cited by
- 30
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2018: 2 · 2017: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Physiology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- Hispana (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- lipolysis, adipose tissue, morbid obesity, visceral fat, subcutaneous abdominal fat, sex differences, catecholamines, adrenergic receptors, beta1-adrenergic receptor, beta3-adrenergic receptor, hormone-sensitive lipase, cyclic AMP, norepinephrine, post-receptor signaling
- MeSH terms
- Adipose Tissue, Adult, Sterol Esterase, Bucladesine, Dose-Response Relationship, Drug, Female, Colforsin, Humans, Lipolysis, Male, Middle Aged, Norepinephrine, Obesity, Morbid, Receptors, Adrenergic, alpha, Receptors, Adrenergic, beta, Sex Factors, Blotting, Western, Body Mass Index, Adipocytes, Intra-Abdominal Fat, Abdominal Fat
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