The DOI matches its Crossref record.
Excitotoxic Amino Acid Receptors in Human Complex Partial Epilepsy
Abstract
It has long been recognized that mesial temporal sclerosis is the most common pathologie finding in temporal lobes removed for the treatment of medically re-fractory complex partial epilepsy. The regions of the hippocampus most vulnerable con-tain the highest densities of excitatory amino acid receptors in the brain. We used receptor autoradiography to determine the density of N-methyl-D-aspartate (NMDA) and kainic acid (KA) receptors from 5 patients undergoing such surgery and compared the findings with 6 specimens obtained at postmortem. A 2-fold increase in the density of NMDA receptors and an increased density of KA receptors was found in entorhinal cortex in epileptic specimens. Loss of NMDA and KA receptor density was apparent in the sclerotic regions CA3 and CAI, but not in other areas of the hippocampus or dentate gyrus. These findings suggest that damage in the hippocampus may result, at least in part, from the presence of aberrant excitatory circuits in the entorhinal cortex.
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In congestive heart failure, low interstitial oncotic pressure acts to protect against the formation of edema, and the model predicts a slightly negative volume flux in this state.
“in congestive heart failure, the low interstitial oncotic pressure acts to protect against the formation of edema [13], with the result that our model predicts a slightly negative volume flux in this state.”
From A First-Order Design Requirement to Prevent Edema in Mechanical Counter-Pressure Space Suit Garments (2019) · cites this paper as [13]
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Ionotropic Glutamate Receptors in Epilepsy: A Review Focusing on AMPA and NMDA Receptors
Hanada, T. (2020) · Biomolecules · doi:10.3390/biom10030464 · Cited by 252
Mesial temporal sclerosis: Pathogenesis and significance
Liu, Z., Mikati, M. A., & Holmes, G. L. (1995) · Pediatric Neurology · doi:10.1016/0887-8994(94)00122-i · Cited by 97
Structure and Biosynthesis of the Antibiotic Bottromycin D
Hou, Y., Tianero, M. D. B., Kwan, J. C., et al. (2012) · Organic Letters · doi:10.1021/ol3022758 · Cited by 85
Brines, M. L., Sundaresan, S., Spencer, D. D., et al. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01371.x · Cited by 51
Lynd‐Balta, E., Pilcher, W. H., & Joseph, S. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00554-4 · Cited by 37
Cell properties in the epileptic hippocampus
Módy, I., & Staley, K. J. (1994) · Hippocampus · doi:10.1002/hipo.450040309 · Cited by 20
Pennell, P. B., Burdette, D. E., Ross, D. A., et al. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb01986.x · Cited by 19
Does a hypertonic saline load predict fluid retention in pacing induced heart failure?
Fu, Y. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00200-3 · Cited by 4
A First-Order Design Requirement to Prevent Edema in Mechanical Counter-Pressure Space Suit Garments
Carr, C. E., & Treviño, L. (2019) · bioRxiv · doi:10.1101/633917 · Cited by 1
Metadata
- Authors
- Cahan, L. D., Geddes, J. W., Choi, B. H., & Cotman, C.
- Affiliations
- University of California, Irvine (US)
- Venue
- Stereotactic and Functional Neurosurgery
- Publisher
- S. Karger AG
- Published
- 1990-11-28
- Volume
- 54-55
- Pages
- 21-24
- ISSN
- 1011-6125 (ISSN-L)
- 1423-0372
- OpenAlex
- W2024167769
- Cited by
- 9
- References
- 0
- Citations by year
- 2020: 1 · 2019: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stereotactic and Functional Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- complex partial epilepsy, hippocampal sclerosis, NMDA receptor, kainic acid receptors, glutamate receptors, entorhinal cortex, hippocampus, CA3, CA1, dentate gyrus, drug-resistant epilepsy, receptor density
- MeSH terms
- Autoradiography, Epilepsy, Temporal Lobe, Hippocampus, Humans, Psychosurgery, Temporal Lobe, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, Kainic Acid Receptors
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