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Cited by 282Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

What is the mammalian dentate gyrus good for?

Treves, A., Tashiro, A., Witter, M.P., Moser, E.I.·2008·Neuroscience
DOI 10.1016/j.neuroscience.2008.04.073
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Abstract

In the mammalian hippocampus, the dentate gyrus (DG) is characterized by sparse and powerful unidirectional projections to CA3 pyramidal cells, the so-called mossy fibers (MF). The MF form a distinct type of synapses, rich in zinc, that appear to duplicate, in terms of the information they convey, what CA3 cells already receive from entorhinal cortex layer II cells, which project both to the DG and to CA3. Computational models have hypothesized that the function of the MF is to enforce a new, well-separated pattern of activity onto CA3 cells, to represent a new memory, prevailing over the interference produced by the traces of older memories already stored on CA3 recurrent collateral connections. Although behavioral observations support the notion that the MF are crucial for decorrelating new memory representations from previous ones, a number of findings require that this view be reassessed and articulated more precisely in the spatial and temporal domains. First, neurophysiological recordings indicate that the very sparse dentate activity is concentrated on cells that display multiple but disorderly place fields, unlike both the single fields typical of CA3 and the multiple regular grid-aligned fields of medial entorhinal cortex. Second, neurogenesis is found to occur in the adult DG, leading to new cells that are functionally added to the existing circuitry, and may account for much of its ongoing activity. Third, a comparative analysis suggests that only mammals have evol…

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  • The DG subregion of the hippocampus mediates episodic memory formation and disambiguation of similar but discrete events (pattern separation).

    “The dentate gyrus (DG) subregion of the hippocampus mediates episodic memory formation and the disambiguation of similar but discrete events, a phenomenon known as pattern separation [3], [4], [5], [6].”

    From Arf4 Determines Dentate Gyrus-Mediated Pattern Separation by Regulating Dendritic Spine Development (2012) · cites this paper as [5]

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Authors
Treves, A., Tashiro, A., Witter, M. P., & Moser, E. I.
Affiliations
  • Scuola Internazionale Superiore di Studi Avanzati (IT)
  • Norwegian University of Science and Technology (NO)
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2008-07
Volume
154
Issue
4
Pages
1155-1172
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2008.04.073
OpenAlex
W2022036472
Cited by
282
References
16
Citations by year
2026: 5 · 2025: 8 · 2024: 9 · 2023: 16 · 2022: 14 · 2021: 13 · 2020: 14 · 2019: 10 · 2018: 16 · 2017: 22 · 2016: 24 · 2015: 25 · 2014: 22 · 2013: 19 · 2012: 20
FWCI
1.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • SDL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
dentate gyrus, mossy fibers, hippocampus, CA3, entorhinal cortex, place fields, memory interference, adult neurogenesis, avian hippocampus, spatial memory, computational model of memory
MeSH terms
Animals, Humans, Memory, Dentate Gyrus

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