The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Emerging Biomarkers of Acute Kidney Injury
Abstract
BACKGROUND: Acute kidney injury (AKI) is a major clinical problem with a rising incidence and high mortality rate. The lack of early biomarkers has resulted in an unacceptable delay in initiating therapies. METHODS: Here we will update the reader on promising new blood and urinary biomarkers that have recently emerged through the application of innovative technologies such as functional genomics and proteomics to human and animal models of AKI. RESULTS: The most promising biomarkers of AKI for clinical use include a plasma panel (NGAL and cystatin C) and a urine panel (NGAL, Il-18 and KIM-1). CONCLUSIONS: As they represent tandem biomarkers, it is likely that the AKI panels will be useful for timing the initial insult and assessing the duration and severity of AKI. Based on the differential expression of the biomarkers, it is also likely that the AKI panels will distinguish between the various types and etiologies of AKI. It will be important in future studies to validate the sensitivity and specificity of these biomarker panels in clinical samples from large cohorts and from multiple clinical situations.
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Cites
Uchino, S. (2005) · JAMA · doi:10.1001/jama.294.7.813 · Cited by 4,176
Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury
Han, W. K., Bailly, V., Abichandani, R., Thadhani, R., & Bonventre, J. V. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00433.x · Cited by 1,929
Serum cystatin C is superior to serum creatinine as a marker of kidney function: A meta-analysis
Dharnidharka, V. R., Kwon, C., & Stevens, G. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.34487 · Cited by 1,663
Update on Mechanisms of Ischemic Acute Kidney Injury
Devarajan, P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010017 · Cited by 1,026
Self-citationMori, K., Lee, H. T., Rapoport, D., Drexler, I. R., Foster, K., Yang, J., Schmidt-Ott, K. M., Chen, X., Li, J. Y., Weiss, S., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23056 · Cited by 954
Self-citationZerhouni, E. (2003) · Science · doi:10.1126/science.1091867 · Cited by 918
Early detection of acute renal failure by serum cystatin C
Herget-rosenTHAL, S., Marggraf, G., Hüsing, J., Göring, F., Pietruck, F., Janssen, O., Philipp, T., & Kribben, A. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00861.x · Cited by 897
Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury
Ichimura, T., Hung, C. C., Yang, S. A., Stevens, J. L., & Bonventre, J. V. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00285.2002 · Cited by 683
Acute renal failure: definitions, diagnosis, pathogenesis, and therapy
Schrier, R. W., Wang, W., Poole, B., & Mitra, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci22353 · Cited by 683
Vaidya, V. S., Ramirez, V., Ichimura, T., Bobadilla, N. A., & Bonventre, J. V. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00291.2005 · Cited by 656
Cited by
Dent, C. L., Ma, Q., Dastrala, S., Bennett, M., Mitsnefes, M. M., Barasch, J., & Devarajan, P. (2007) · Critical Care · doi:10.1186/cc6192 · Cited by 483
Self-citationLiver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery
Portilla, D., Dent, C., Sugaya, T., Nagothu, K. K., Kundi, I., Moore, P., Noiri, E., & Devarajan, P. (2008) · Kidney International · doi:10.1038/sj.ki.5002721 · Cited by 403
Self-citationBiomarkers in acute kidney injury – pathophysiological basis and clinical performance
Schrezenmeier, E. V., Barasch, J., Budde, K., Westhoff, T., & Schmidt‐Ott, K. M. (2017) · Acta Physiologica · doi:10.1111/apha.12764 · Cited by 401
Chawla, L. S., Davison, D. L., Brasha-Mitchell, E., Koyner, J. L., Arthur, J. M., Shaw, A. D., Tumlin, J. A., Trevino, S. A., Kimmel, P. L., & Seneff, M. G. (2013) · Critical Care · doi:10.1186/cc13015 · Cited by 398
Neutrophil Gelatinase-Associated Lipocalin: A� Promising Biomarker for Human Acute Kidney Injury
Devarajan, P. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.12 · Cited by 332
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Metadata
- Authors
- Devarajan, P.
- Venue
- Contributions to Nephrology
- Publisher
- KARGER
- Published
- 2007
- Volume
- 156
- Pages
- 203-212
- OpenAlex
- W1540734062
- Cited by
- 276
- References
- 31
- FWCI
- 61.80
- Type
- book chapter
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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