Validity of Dementia Diagnoses in the Danish Hospital Registers
Abstract
Background:The validity of dementia diagnoses in the Danish nationwide hospital registers was evaluated to determine the value of these registers in epidemiological research about dementia. Methods: Two hundred patients were randomly selected from 4,682 patients registered for the first time with a dementia diagnosis in the last 6 months of 2003. The patients’ medical journals were reviewed to evaluate if they fulfilled ICD-10 and/or DSM-IV criteria for dementia and specific dementia subtypes. The patients who were still alive in 2006 were invited to an interview. Results: One hundred and ninety-seven journals were available for review and 51 patients were interviewed. A registered diagnosis of dementia was found to be correct in 169 (85.8%) cases. Regarding dementia subtypes, the degree of agreement between the registers and the results of the validating process was low with a kappa of 0.36 (95% CI 0.24–0.48). Conclusion: The validity of dementia syndrome in the Danish hospital registers was high and allows for epidemiological studies about dementia. Alzheimer’s disease, although underregistered, also had a good validity once the diagnosis was registered. In general, other ICD-10 dementia subtypes in the registers had a low validity and are less suitable for epidemiological research.
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Dementia diagnoses in the Danish registries have high diagnostic validity, and any unregistered events would only lead to decreased power and bias results toward the null hypothesis.
“One potential limitation concerns the validity of the dementia diagnoses; however, the national Danish Patient Registry includes all hospital visits, and dementia diagnoses in the Danish registries have high diagnostic validity 19 , 44 ; any unregistered events would only lead to decreased power of estimates and bias results toward the null hypothesis.”
From <i>APOE</i> and dementia – resequencing and genotyping in 105,597 individuals (2020) · cites this paper as [44]
Dementia diagnoses in the Danish registries have high diagnostic validity.
“Dementia diagnoses in the Danish registries have high diagnostic validity.24,76”
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Self-citation
- Authors
- Phung, T. K. T., Andersen, B. B., Høgh, P., Kessing, L. V., Mortensen, P. B., & Waldemar, G.
- Affiliations
- Copenhagen University Hospital (DK)
- Aarhus University Hospital (DK)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2007
- Volume
- 24
- Issue
- 3
- Pages
- 220-228
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2124969446
- Cited by
- 279
- References
- 32
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 20 · 2023: 14 · 2022: 24 · 2021: 27 · 2020: 25 · 2019: 20 · 2018: 18 · 2017: 16 · 2016: 20 · 2015: 9 · 2014: 11 · 2013: 7 · 2012: 7
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- H. Lundbeck A/S
- Fondation pour la Recherche sur Alzheimer
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Health Professions › Health Information Management › Medical Coding and Health Information
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Reliability and Agreement in Measurement
- Keywords
- dementia, diagnostic validity, hospital registers, ICD-10, DSM-IV, Alzheimer's disease, dementia subtypes
- MeSH terms
- Aged, Aged, 80 and over, Dementia, Denmark, Female, Humans, Interview, Psychological, Male, Medical Records, Neuropsychological Tests, Psychiatric Status Rating Scales, Registries, Reproducibility of Results
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