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Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats
Abstract
Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY might have a role in the onset of maternal behavior at parturition, we have used both antisera to OXY and an analog antagonist of OXY, d(CH2)5–8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a pregnancy-terminated preparation which yields reliable short-latency maternal behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of antisera to OXY or of the i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin on the latency to respond to pups were tested by presenting pups 48 h after surgery and EB treatment. Behavioral observations were made for the next 5 h and periodically over the next 5 days. Groups receiving either the antisera to OXY or the analog antagonist had significantly longer latencies to respond to pups than did control groups. In a separate experiment, i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin was shown to have no effect on the performance of maternal behavior in lactating rats 5 days postpartum. These results suggest that OXY may have a role in promoting short-latency maternal behavior in steroid-primed female rats, but that it is probably not involved in sustaining this behavior during lactation.
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“OT is released centrally and peripherally during birth, and centrally released OT is both necessary for the rapid onset of maternal behavior in virgin rats, and sufficient to induce it (Pedersen and Prange 1979; Fahrbach et al 1985; van Leengoed et al 1987; Borrow and Cameron 2012).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Fahrbach et al 1985
In the citing paper
“However, OT does not appear to be necessary for the maintenance of maternal behavior in experienced females (Fahrbach et al 1985).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Fahrbach et al 1985
In the citing paper
“The importance of the oxytocin system in mammalian social behaviors including social memory, recognition and attachment has been established using a variety of animal models since 1980s.”
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Items 301–321 of 321
Freedman, D. G. (1992) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00069806
Behavioural, aminergic and neural systems in attachment
Salzen, E. A. (1992) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00069880
Effects of Oxytocin in the Medial Prefrontal Cortex: Anxiety, Maternal Care, and Maternal Aggression
Sabihi, S. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
Mooney, S. J. (2011) · TSpace (University of Toronto)
Young, L. J., & Zingg, H. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00056-0
Featherstone, R. E. (1997) · Library and Archives Canada (Government of Canada)
Evolutionary Perspectives on the Parental Brain
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0011
Anxiety Reduction and Maternal Aggression in Postpartum Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0006
Development of the Parental Brain in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0009
Development of the Parental Brain in Humans
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0010
Brain Mechanisms Regulating Maternal Behavior in Nonhuman Mammals
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.003.0004
Pfaff, D. W. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-85861-8.00008-6
Self-citationYoung, L. J., & Zingg, H. H. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00048-6
(2015) · Elsevier eBooks · doi:10.1016/b978-0-12-416040-8.16001-8
The neurogenetic background of parental care
Fazekas, E. A. (2021) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2020.149
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0006
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0003
Abbreviations Used for Major Brain Regions
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0007
Numan, M. (2020) · Oxford University Press eBooks · doi:10.1093/oso/9780190848675.002.0004
The oxytocinergic descending control of pain and its modulation by neonatal maternal separation
Melchior, M. (2018) · theses.fr (ABES) · doi:10.70675/368c73c0ze731z4b57zb52cz8f31049fb33c
Opioids and the oxytocin system: Mechanistic interactions altering maternal neuroplasticity
Richardson, L. M., Veenema, A. H., & Brummelte, S. (2026) · Journal of Neuroendocrinology · doi:10.1111/jne.70293
Metadata
- Authors
- Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W.
- Affiliations
- Rockefeller University (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-03-28
- Volume
- 40
- Issue
- 6
- Pages
- 526-532
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1965235291
- Cited by
- 322
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 19 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 6 · 2014: 13 · 2013: 6 · 2012: 8
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, maternal behavior, estrogen, estradiol benzoate, arginine vasotocin, oxytocin antagonist, abortion (veterinary), childbirth, lactation, postpartum behavior, intracerebroventricular infusion
- MeSH terms
- Animals, Estradiol, Female, Immune Sera, Lactation, Maternal Behavior, Oxytocin, Pregnancy, Rats, Inbred Strains, Time Factors, Rats
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