Cited by 322Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats

Fahrbach, Susan E., Morrell, Joan I., Pfaff, Donald W.·2008·Neuroendocrinology

DOI 10.1159/000124125

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Abstract

Intracerebroventricular (i.c.v.) infusions of oxytocin (OXY) induce short-latency maternal behavior in estrogen-primed virgin rats. To investigate if brain OXY might have a role in the onset of maternal behavior at parturition, we have used both antisera to OXY and an analog antagonist of OXY, d(CH2)5–8-ornithine-vasotocin, to reduce the activity of endogenous OXY in a pregnancy-terminated preparation which yields reliable short-latency maternal behavior. Sprague-Dawley rats with lateral ventricle cannulae were ovariectomized and hysterectomized on day 16 of gestation; maternal behavior was stimulated by a s.c. injection of estradiol benzoate (EB). Effects of the i.c.v. infusion of antisera to OXY or of the i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin on the latency to respond to pups were tested by presenting pups 48 h after surgery and EB treatment. Behavioral observations were made for the next 5 h and periodically over the next 5 days. Groups receiving either the antisera to OXY or the analog antagonist had significantly longer latencies to respond to pups than did control groups. In a separate experiment, i.c.v. infusion of d(CH2)5–8-ornithine-vasotocin was shown to have no effect on the performance of maternal behavior in lactating rats 5 days postpartum. These results suggest that OXY may have a role in promoting short-latency maternal behavior in steroid-primed female rats, but that it is probably not involved in sustaining this behavior during lactation.

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Authors: Fahrbach, S. E., Morrell, J. I., & Pfaff, D. W.
Affiliations: Rockefeller University (US)
ORCID: Fahrbach, Susan E.
Pfaff, Donald W.
Venue: Neuroendocrinology
Publisher: S. Karger AG
Published: 2008-03-28
Volume: 40
Issue: 6
Pages: 526-532
ISSN: 0028-3835 (ISSN-L)
1423-0194
DOI: 10.1159/000124125
OpenAlex: W1965235291
Cited by: 322
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 19 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 7 · 2015: 6 · 2014: 13 · 2013: 6 · 2012: 8
FWCI: 14.67
Type: journal article
Language: en
Open access: closed
Licence: karger.com/pages/terms-and-conditions (vor)
karger.com/pages/terms-and-conditions (tdm)
Locations: Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: oxytocin, maternal behavior, estrogen, estradiol benzoate, arginine vasotocin, oxytocin antagonist, abortion (veterinary), childbirth, lactation, postpartum behavior, intracerebroventricular infusion
MeSH terms: Animals, Estradiol, Female, Immune Sera, Lactation, Maternal Behavior, Oxytocin, Pregnancy, Rats, Inbred Strains, Time Factors, Rats

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Possible Role for Endogenous Oxytocin in Estrogen-Facilitated Maternal Behavior in Rats

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