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Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty
Abstract
In both rats and primates, including humans, serum levels of insulin-like growth factor I (IGF-I) increase during the onset of puberty, suggesting a role for IGF-I in this process. We examined the ability of IGF-I to affect the release of hypothalamic luteinizing hormone releasing hormone (LHRH) in prepubertal female rats. Our results indicate that IGF-I acts on the median eminence, which contains the highest density of type 1 IGF receptors in the brain, to elicit a dose-related increase in LHRH release. In this regard, a minimal effective dose of 10 ng/ml (p less than 0.05) and a maximal effective dose of 100 ng/ml (p less than 0.01) was observed. IGF-II and insulin were one order of magnitude less effective. The results demonstrate that IGF-I has the capability to act directly upon the median eminence to effect release of LHRH, thereby suggesting a role for IGF-I in facilitating peripubertal changes in LHRH release. Thus, IGF-I may represent one of the 'metabolic signals' thought to be involved in the initiation of puberty.
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Cited by
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Is there a causal relationship between obesity and puberty?
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Metadata
- Authors
- Hiney, J. K., Ojeda, S. R., & Dees, L.
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 1991
- Volume
- 54
- Issue
- 4
- Pages
- 420-423
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2088127887
- Cited by
- 217
- References
- 0
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty. https://app.cochat.ai/papers/10.1159/000125924
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- Hiney, J. K., Ojeda, S. R., & Dees, L. (1991). Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty. Neuroendocrinology. https://doi.org/10.1159/000125924
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
