Oxytocin Nerve Fibers Innervate β-Endorphin Neurons in the Arcuate Nucleus of the Rat Hypothalamus
Abstract
Fine, varicose oxytocin-containing nerve fibers have been demonstrated in the hypothalamic arcuate nucleus in rats. Using Phaseolus vulgaris leukoagglutinin as an anterograde tracer, fine neuronal fibers of paraventricular nucleus origin could be seen throughout the arcuate nucleus. Using double immunostaining, oxytocin-immunoreactive varicose fibers were observed around or in the close vicinity of β-endorphin-immunoreactive neurons. Silver-gold-labeled oxytocin-immunoreactive presynaptic boutons were shown to make synaptic contacts with diaminobenzidine-labeled β-endorphin-immunoreactive neurons by electron microscopy. These findings provide morphological evidence for a possible influence of oxytocin on the activity of the brain β-endorphin system at the hypothalamic level.
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During the consummatory phase of 'liking', oxytocin has the potential to increase opioid release in the brain by up to 300%.
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Holst, S. (2007)
- Authors
- Csiffáry, A., Ruttner, Z., Tóth, Z., & Palkovits, M.
- Affiliations
- National Institute of Mental Health (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Semmelweis University (HU)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-07
- Volume
- 56
- Issue
- 3
- Pages
- 429-435
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2029054738
- Cited by
- 37
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, beta-endorphin, arcuate nucleus, hypothalamus, paraventricular nucleus, varicose nerve fibers, synaptic connectivity, presynaptic terminals, neuropeptide interactions
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, beta-Endorphin, Female, Fixatives, Immunoenzyme Techniques, Microscopy, Electron, Nerve Fibers, Neurons, Oxytocin, Phytohemagglutinins, Staining and Labeling, Rats, Sprague-Dawley, Rats
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