Neurobiological correlates of social functioning in autism

Neuhaus, Emily; Beauchaine, Theodore P.; Bernier, Raphael

doi:10.1016/j.cpr.2010.05.007

Cited by 122Autism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorAction Observation and Synchronization

Neurobiological correlates of social functioning in autism

Neuhaus, Emily, Beauchaine, Theodore P., Bernier, Raphael·2010·Clinical Psychology Review

DOI 10.1016/j.cpr.2010.05.007

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Abstract

Although autism is defined by deficits in three areas of functioning (social, communicative, and behavioral), impairments in social interest and restricted behavioral repertoires are central to the disorder. As a result, a detailed understanding of the neurobiological systems subserving social behavior may have implications for prevention, early identification, and intervention for affected families. In this paper, we review a number of potential neurobiological mechanisms--across several levels of analysis--that subserve normative social functioning. These include neural networks, neurotransmitters, and hormone systems. After describing the typical functioning of each system, we review available empirical findings specific to autism. Among the most promising potential mechanisms of social behavioral deficits in autism are those involving neural networks including the amygdala, the mesocorticolimbic dopamine system, and the oxytocin system. Particularly compelling are explanatory models that integrate mechanisms across biological systems, such as those linking dopamine and oxytocin with brain regions critical to reward processing.

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The amygdala has been repeatedly linked to the social deficits present in ASD.
“The amygdala has been repeatedly linked to the social deficits present in ASD [41,56].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [56]

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Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders
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Postnatal maturation of GABAergic transmission in the rat basolateral amygdala.
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Diminished Medial Prefrontal Activity behind Autistic Social Judgments of Incongruent Information
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Oxytocin activation of neurons in ventral tegmental area and interfascicular nucleus of mouse midbrain
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Region Specific Up-Regulation of Oxytocin Receptors in the Opioid Oprm1âˆ’/âˆ’ Mouse Model of Autism
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Autism and Emotion
Hobson, R. P. (2014) · Wiley eBooks · doi:10.1002/9781118911389.hautc14 · Cited by 59 · see citing works
Social neuroscience in psychiatry: unravelling the neural mechanisms of social dysfunction
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A Musicoterapia e o Transtorno do Espectro do Autismo: uma abordagem informada pelas neurociências para a prática clínica
Sampaio, R. T., Loureiro, C. M. V., & Gomes, C. M. A. (2015) · Per Musi · doi:10.1590/permusi2015b3205 · Cited by 47 · see citing works
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Reward‐Based Decision Making and Electrodermal Responding by Young Children with Autism Spectrum Disorders during a Gambling Task
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Child psychiatry
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Oscillatory rhythm of reward: anticipation and processing of rewards in children with and without autism
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Balance between projecting neuronal populations of the nucleus accumbens controls social behavior in mice
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Altered Hippocampal Neurogenesis and Amygdalar Neuronal Activity in Adult Mice with Repeated Experience of Aggression
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Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats
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Biological pathways and genetic mechanisms involved in social functioning
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Propionic Acid Animal Model of Autism
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The Relationship Between Early Neural Responses to Emotional Faces at Age 3 and Later Autism and Anxiety Symptoms in Adolescents with Autism
Neuhaus, E., Jones, E. J. H., Barnes, K., Sterling, L., Estes, A. M., MUNSON, J. A., Dawson, G., & Webb, S. J. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2780-y · Cited by 28 · see citing works
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Neural Correlates of Deficits in Humor Appreciation in Gelotophobics
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Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism
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Comparative gene expression analysis of the amygdala in autistic rat models produced by pre- and post-natal exposures to valproic acid
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Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
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Increased Expression of Kv10.2 in the Hippocampus Attenuates Valproic Acid-Induced Autism-Like Behaviors in Rats
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Abnormal Social Behaviors and Dysfunction of Autism-Related Genes Associated With Daily Agonistic Interactions in Mice
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Authors: Neuhaus, E., Beauchaine, T. P., & Bernier, R.
Affiliations: University of Washington (US)
Stony Brook University (US)
Corresponding author: Neuhaus, Emily
ORCID: Neuhaus, Emily
Beauchaine, Theodore P.
Bernier, Raphael
Venue: Clinical Psychology Review
Publisher: Elsevier BV
Published: 2010-08
Volume: 30
Issue: 6
Pages: 733-748
ISSN: 0272-7358 (ISSN-L)
DOI: 10.1016/j.cpr.2010.05.007
OpenAlex: W2167454770
Cited by: 122
References: 273
Citations by year: 2026: 4 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 18 · 2012: 17
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Clinical Psychology Review (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
Keywords: autism spectrum disorder, social functioning, social behavior deficits, artificial neural networks, amygdala, mesocorticolimbic dopamine system, oxytocinergic system, neurotransmitters, hormone system, reward processing, social interest
MeSH terms: Autistic Disorder, Brain, Humans, Neural Pathways, Social Adjustment, Social Environment

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