Direct Regulation of Hypothalamic Corticotropin-Releasing-Hormone Neurons by Angiotensin II
Abstract
The possible role of angiotensin II (AII) in the control of the hypothalamic-pituitary-adrenal (HPA) axis was studied in the rat by examining the regulation and cellular localization of AII receptors in the paraventricular nucleus (PVN) of the hypothalamus and the effect of AII on corticotropin-releasing hormone (CRH) and vasopressin (VP) mRNA levels. In situ hybridization studies using cRNA 35S-labelled probes showed that while type 1 AII receptor (AT 1) mRNA levels were high in the periventricular and parvicellular pars of the PVN, only very low levels were present in the magnocellular pars. A similar distribution of AT 1 receptor binding in the periventricular, parvicellular and magnocellular divisions of the PVN was observed in autoradiographic studies in hypothalamic sections labelled with 125I[Sar1,Ile8]AΠ. In addition, AII receptor binding was clearly evident in nerve fibers adjacent to the PVN. Double-labelling hybridization using digoxigenin-labelled CRH, VP and oxytocin probes and 35S-labelled AT 1 receptor cRNA probes showed AT 1 receptor mRNA in cells stained for CRH mRNA, but not in VP or oxytocin cells. Four hours after a single intracerebroventricular (i.c.v.) injection of 50 ng AII in conscious rats, CRH mRNA levels in the PVN were increased by 43%, similar to the increases observed following acute stress by intraperitoneal (i.p.) injection of 1.5 M NaCl (76%). On the other hand, while i.p. hypertonic saline injection increased VP mRNA levels by 29% in the PVN and by 32% in the supraoptic nucleus, i.c.v. AII injection had no significant effect. The data strongly suggest that AII modulates CRH neurons directly through receptors in PVN perikarya, whereas regulation of magnocellular function is at least partly indirect via receptors associated with afferent innervation to the PVN. The data support a direct role for AII in the regulation of PVN function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ATII is a circulating endocrine factor that can trigger CRF production during stress.
“ATII is a circulating endocrine factor that can trigger CRF production in response to stress82.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [82]
Cited by
Sorted by citations
International Union of Pharmacology. XXIII. The Angiotensin II Receptors
Marc De Gasparo, B., Catt, K. J., Inagami, T., Wright, J. W., & Unger, T. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01458-3 · Cited by 2,131 · see citing works
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress
Smith, S. M., & Vale, W. W. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/ssmith · Cited by 1,948 · see citing works
The brain renin–angiotensin system: location and physiological roles
McKinley, M. J., Albiston, A. L., Allen, A. M., Mathai, M. L., May, C. N., McAllen, R. M., Oldfield, B. J., Mendelsohn, F. A. O., & Chai, S. Y. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00306-0 · Cited by 504 · see citing works
Lenkei, Z., Palkovits, M., Corvol, P. L., & Llorens‐Cortés, C. (1997) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1997.0155 · Cited by 405 · see citing works
Neural mechanisms of social homeostasis
Matthews, G. A., & Tye, K. M. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14016 · Cited by 273 · see citing works
Brain Angiotensin II: New Developments, Unanswered Questions and Therapeutic Opportunities
Saavedra, J. M. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4011-5 · Cited by 281 · see citing works
“5) (Castrén and Saavedra, 1988; Aguilera et al., 1995a; Jezova et al., 1998; Leong et al., 2002).”
Saavedra, J. M., Sánchez-Lemus, E., & Benický, J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.10.001 · Cited by 260 · see citing works
“In the paraventricular nucleus, AT1 receptors are expressed in parvocellular corticotrophin-releasing factor (CRF) forming neurons controlling CRF release during stress (Aguilera et al., 1995).”
BackgroundAngiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders
Saavedra, J. M. (2012) · Clinical Science · doi:10.1042/cs20120078 · Cited by 219 · see citing works
The molecular physiology of CRH neurons
Aguilera, G., & Liu, Y. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.08.002 · Cited by 198 · see citing works
Self-citationThe renin angiotensin system and the metabolic syndrome
de Kloet, A. D., Krause, E. G., & Woods, S. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.018 · Cited by 194 · see citing works
Brain and peripheral angiotensin II play a major role in stress
Saavedra, J. M., & Benický, J. (2007) · Stress · doi:10.1080/10253890701350735 · Cited by 166 · see citing works
“Glucocorticoids are not only able to stimulate AT1 receptor expression during stress, but they are also necessary to maintain basal AT1 receptor expression (Castrén and Saavedra 1989; Aguilera et al. 1995b).”
BackgroundInfluentialMagnesium and Affective Disorders
Murck, H. (2002) · Nutritional Neuroscience · doi:10.1080/1028415021000039194 · Cited by 157 · see citing works
“Activation of ATII receptors in the PVN lead to an increase in CRH mRNA (Aguilera et al., 1995), whereas blocking ATII receptors by i.”
BackgroundArmando, I., Carranza, A., Nishimura, Y., Hoe, K.-L., Barontini, M., Terrón, J. A., Falcón-Neri, A., Ito, T., Juorio, A. V., & Saavedra, J. M. (2001) · Endocrinology · doi:10.1210/endo.142.9.8366 · Cited by 148 · see citing works
The renin–angiotensin system: a possible new target for depression
Vian, J., Pereira, C. L., Chavarria, V., Köhler, C. A., Stubbs, B., Quevedo, J., Kim, S., Carvalho, A. F., Berk, M., & Fernandes, B. S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0916-3 · Cited by 132 · see citing works
Brudey, C., Park, J., Wiaderkiewicz, J., Kobayashi, I., Mellman, T. A., & Marvar, P. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00343.2014 · Cited by 131 · see citing works
Ježová, D., Ochędalski, T., Kiss, A., & Aguilera, G. (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00182.x · Cited by 127 · see citing works
Self-citationZiegler, D. R. (2002) · Integrative and Comparative Biology · doi:10.1093/icb/42.3.541 · Cited by 127 · see citing works
Hormonal and Neurotransmitter Roles for Angiotensin in the Regulation of Central Autonomic Function
Ferguson, A. V., Washburn, D. L. S., & Latchford, K. J. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600205 · Cited by 125 · see citing works
Anti-stress and anti-anxiety effects of centrally acting angiotensin II AT1 receptor antagonists
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., Juorio, A. V., & Macova, M. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2004.12.015 · Cited by 119 · see citing works
Distribution of angiotensin type-1 receptor messenger RNA expression in the adult rat brain
Lenkei, Z., Palkovits, M., Corvol, P. L., & Llorens‐Cortés, C. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00328-x · Cited by 115 · see citing works
Saavedra, J. M., Armando, I., Bregonzio, C., Juorio, A. V., Macova, M., Pavel, J., & Sánchez-Lemus, E. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300921 · Cited by 109 · see citing works
“In addition, isolation (Armando et al, 2001; present results) and restraint (Castrén and Saavedra, 1988; Leong et al, 2002; Aguilera et al, 1995a) increased AT1 receptor expression in brain areas inside and outside the blood– brain barrier and related to the control of the hormonal and…”
BackgroundInfluentialAguilera, G., KISS, A. J., & Luo, X. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00714.x · Cited by 103 · see citing works
Self-citationde Kloet, A. D., Wang, L. A., Pitra, S., Hiller, H., Smith, J. A., Tan, Y., Nguyen, D., Cahill, K. M., Sumners, C., Stern, J. E., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3674-16.2017 · Cited by 90 · see citing works
“While AT1aRs are known to influence neuroendocrine secretion (Aguilera et al., 1995) and sympathetic outflow (Li et al., 2003; Cato and Toney, 2005; Li and Pan, 2005; de Kloet et al., 2011), technical limitations that make it impossible to precisely locate AT1aRs in cells have so far prevented…”
BackgroundAdrenocortical dysregulation as a major player in insulin resistance and onset of obesity
Roberge, C., Carpentier, A. C., Langlois, M., Baillargeon, J., Ardilouze, J., Maheux, P., & Gallo‐Payet, N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00516.2007 · Cited by 87 · see citing works
“93), increasing the expression of CRH in the paraventricular nucleus (PVN), in the hypothalamus (2, 10, 92).”
Armando, I., Volpi, S., Aguilera, G., & Saavedra, J. M. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.037 · Cited by 86 · see citing works
“There is evidence suggesting that AT1 receptors play a role in increasing CRF formation (Aguilera et al., 1995b; Sumitomo et al., 1991) and release into the hypothalamic portal system, contributing to the stimulation of pituitary ACTH (Aguilera et al., 1983) and adrenal corticoid production and…”
BackgroundResultInfluentialSelf-citationEmerging features of brain angiotensin receptors
Saavedra, J. M. (1999) · Regulatory Peptides · doi:10.1016/s0167-0115(99)00081-6 · Cited by 84 · see citing works
Brain Angiotensin II, an Important Stress Hormone: Regulatory Sites and Therapeutic Opportunities
Saavedra, J. M., Ando, H., Armando, I., Baiardi, G., Bregonzio, C., JEZOVA, M., & Zhou, J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1296.009 · Cited by 84 · see citing works
Rapid and Sensitive Vasopressin Heteronuclear RNA Responses to Changes in Plasma Osmolality
Arima, Kondo, Kakiya, et al. (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00308.x · Cited by 81 · see citing works
Ježová, D., Ochędalski, T., Glickman, M., Kiss, A., & Aguilera, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00333-4 · Cited by 80 · see citing works
Self-citationde Kloet, A. D., Pati, D., Wang, L. A., Hiller, H., Sumners, C., Frazier, C. J., Seeley, R. J., Herman, J. P., Woods, S. C., & Krause, E. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3806-12.2013 · Cited by 77 · see citing works
“Within the PVN, AT1a influence the activity of neurosecretory (Sumitomo et al., 1991; Aguilera et al., 1995) and pre-autonomic (Cato and Toney, 2005) neurons that are known to express CRH and OXT (Cechetto and Saper, 1988).”
Leong, D. S., Terrón, J. A., Falcón‐Neri, A., Armando, I., Ito, T., Jöhren, O., Tonelli, L. H., Hoe, K., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000054714 · Cited by 77 · see citing works
Peripherally Administered Angiotensin II AT1 Receptor Antagonists Are Anti‐stress Compounds in Vivo
Pavel, J., Benický, J., Murakami, Y., Sánchez-Lemus, E., & Saavedra, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.006 · Cited by 74 · see citing works
Central angiotensin II has catabolic action at white and brown adipose tissue
de Kloet, A. D., Krause, E. G., Scott, K. A., Foster, M. T., Herman, J. P., Sakai, R. R., Seeley, R. J., & Woods, S. C. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2011 · Cited by 74 · see citing works
“Within the PVN, AT1 is expressed on CRH-containing neurons (2, 79), and CRH induces anorexia, elevates energy expenditure, and enhances sympathetic outflow (67).”
Effect of intracerebroventricular angiotensin II on body weight and food intake in adult rats
Porter, J. P., & Potratz, K. R. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00537.2003 · Cited by 69 · see citing works
Pavlatou, M. G., Mastorakos, G., Lekakis, I., Liatis, S., Vamvakou, G., Zoumakis, E., Papassotiriou, I., Rabavilas, A. D., Katsilambros, N., & Chrousos, G. P. (2008) · Stress · doi:10.1080/10253890701476621 · Cited by 66 · see citing works
“Ang II modulates CRH neurons directly in the rat hypothalamus, through AT1 receptors, which are located in the perikarya of the periventricular and parvicellular divisions of the paraventricular nucleus (Aguilera et al. 1995; Latchford and Ferguson 2005).”
BackgroundThe Renin Anggiotensin System and the Stress Response
Aguilera, G., Kiss, A., LUO, X., & Akbaşak, B. S. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb44679.x · Cited by 64 · see citing works
Self-citationSalt appetite: a neurohormonal viewpoint
Daniels, D., & Fluharty, S. J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.013 · Cited by 64 · see citing works
Seltzer, A. M., Bregonzio, C., Armando, I., Baiardi, G., & Saavedra, J. M. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.079 · Cited by 63 · see citing works
Itoi, K., Seasholtz, A. F., & Watson, S. J. (1998) · Endocrine Journal · doi:10.1507/endocrj.45.13 · Cited by 61 · see citing works
Bregonzio, C., Seltzer, A. M., Armando, I., Pavel, J., & Saavedra, J. M. (2008) · Stress · doi:10.1080/10253890801892040 · Cited by 53 · see citing works
Effect of central angiotensin II on body weight gain in young rats
Porter, J. P., Anderson, J. M., Robison, R. J., & Phillips, A. C. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03676-4 · Cited by 53 · see citing works
Sumners, C., Alleyne, A. R., Rodríguez, V., Pioquinto, D. J., Ludin, J. A., Kar, S., Winder, Z., Ortiz, Y. T., Liu, M., Krause, E. G., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0374-8 · Cited by 47 · see citing works
Recent Advances in the Understanding of Water Metabolism in Heart Failure
Schrier, R. W., & Martin, P.-Y. (1998) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-4871-3_53 · Cited by 45 · see citing works
Involvement of central angiotensin receptors in stress adaptation
Dumont, É. C., Rafrafi, S., Laforest, S., & Drolet, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00206-7 · Cited by 44 · see citing works
Wang, L. A., de Kloet, A. D., Smeltzer, M. D., Cahill, K. M., Hiller, H., Bruce, E. B., Pioquinto, D. J., Ludin, J. A., Katovich, M. J., Raizada, M. K., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.025 · Cited by 43 · see citing works
“Consistent with prior research (Aguilera et al., 1995; Oldfield et al., 2001), a recent study from our laboratory found that nearly every CRH producing neuron in the PVN also expresses AT1aR(s) and selective optogenetic excitation of such neurons robustly activates the HPA axis (de Kloet et al.,…”
Luo, H., Wu, P., Cao, Y., Jin, M. J., Shen, T., Wang, J., Huang, J., Han, Q.-Q., He, J., Deng, S., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.02.005 · Cited by 42 · see citing works
Yu, X., Suo, Y., Qi, J., Yang, Q., Li, H., Zhang, D., Yi, Q.-Y., Zhang, J., Zhu, G., Zhu, Z., et al. (2013) · Cardiovascular Toxicology · doi:10.1007/s12012-013-9219-x · Cited by 41 · see citing works
Wang, L. A., Hiller, H., Smith, J. A., de Kloet, A. D., & Krause, E. G. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00029.2016 · Cited by 39 · see citing works
“In regard to functionality, acute injection or chronic infusion of exogenous ANG II into the brain increases CRH mRNA in the PVN (3, 12), indicating that AT1a stimulation in the PVN may regulate CRH expression.”
BackgroundInfluentialElsaafien, K., Kirchner, M., Mohammed, M., Eikenberry, S., West, C. L., Scott, K., de Kloet, A. D., Stern, J., & Krause, E. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0251-21.2021 · Cited by 34 · see citing works
AGTR1 gene variation: Association with depression and frontotemporal morphology
Taylor, W. D., Benjamin, S., McQuoid, D. R., Payne, M. E., Krishnan, R. R., MacFall, J. R., & Ashley‐Koch, A. E. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.03.007 · Cited by 40 · see citing works
“Increased RAS activity, mediated by angiotensin II, directly influences many molecular systems implicated in MDD, including 1) stimulation of the HPA axis by stimulating the production and release of corticotrophin releasing factor (CRF) (Aguilera et al., 1995); 2) inhibition of neurogenesis and neuroplasticity (Castr…”
BackgroundSladek, C. D., Michelini, L. C., Stachenfeld, N. S., Stern, J. E., & Urban, J. H. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140028 · Cited by 49 · see citing works
Sandgren, J. A., Linggonegoro, D. W., Zhang, S. Y., Sapouckey, S. A., Claflin, K. E., Pearson, N. A., Leidinger, M., Pierce, G. L., Santillan, M. K. O., Gibson-Corley, K. N., et al. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00435.2017 · Cited by 39 · see citing works
Hurt, R. C., Garrett, J. C., Keifer, O. P., Linares, A., Couling, L. E., Speth, R. C., Ressler, K. J., & Marvar, P. J. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12235 · Cited by 39 · see citing works
Osmotic regulation of angiotensin AT1 receptor subtypes in mouse brain
Chen, Y., Rocha, M. J. A., & Morris, M. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04059-3 · Cited by 39 · see citing works
Adrenal Insufficiency in Septic Shock
Maxime, V., Lesur, O., & Annane, D. (2009) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2008.10.003 · Cited by 39 · see citing works
Angiotensin I‐converting enzyme I/D polymorphism and suicidal behaviors
Sparks, D. L., Hunsaker, J. C., Amouyel, P., Malafosse, A., Bellivier, F., Leboyer, M., Courtet, P., & Helbecque, N. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30793 · Cited by 36 · see citing works
“…secretion of pituitary hormones such as corticotropin (ACTH) and potentiates the stimulatory effects of corticotropin releasing hormone (CRH) [Jezova et al., 1998], suggesting that the brain RAS is involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis [Aguilera et al., 1995].”
BackgroundAssociation between a functional polymorphism in the renin-angiotensin system and completed suicide
Hishimoto, A., Shirakawa, O., Nishiguchi, N., Hashimoto, T., Yanagi, M., Nushida, H., Ueno, Y., & Maeda, K. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0483-9 · Cited by 36 · see citing works
“Central administration of Ang II stim- ulates CRH synthesis and release (Aguilera et al., 1995b).”
Latchford, K. J., & Ferguson, A. V. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00549.2004 · Cited by 36 · see citing works
Armando, I., Terrón, J. A., Falcón‐Neri, A., Takeshi, I., Häuser, W., Inagami, T., & Saavedra, J. M. (2002) · Neuroendocrinology · doi:10.1159/000064525 · Cited by 35 · see citing works
KISS, A. J., & Aguilera, G. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1007098724683 · Cited by 35 · see citing works
“For example, CRH mRNA levels in the PVN are elevated 3 N 4 hr following icv injection of angiotensin II (Sumimoto et al., 1991; Aguilera et al., 1995), and receptors for the peptide are present in CRH neurons (Aguilera et al.”
InfluentialSelf-citationColeman, C. G., Anrather, J., Iadecola, C., & Pickel, V. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.06.032 · Cited by 34 · see citing works
“The ambiguity arises in part because multiple studies in rat have shown that the AT1 receptor is principally expressed in PVN neurons containing corticotropin-releasing hormone, not VP (Aguilera et al., 1995; Lenkei et al., 1995; Armando et al., 2007).”
Wincewicz, D., & Braszko, J. J. (2014) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/1470320314526269 · Cited by 33 · see citing works
Candesartan prevents impairment of recall caused by repeated stress in rats
Braszko, J. J., Wincewicz, D., & Jakubów, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2829-3 · Cited by 32 · see citing works
“…with the increased AT1 receptor expression, activates the HPA axis and enhances corticotrophin-releasing hormone (CRH) formation and release (Aguilera et al. 1995a, b; Sumimoto et al. 1991) that further increases pituitary ACTH release followed by an increase of corticosterone formation and…”
Marques-Lopes, J., Lynch, M., Kempen, T. A. V., Waters, E. M., Wang, G., Iadecola, C., Pickel, V. M., & Milner, T. A. (2015) · Synapse · doi:10.1002/syn.21800 · Cited by 32 · see citing works
“…and ERb are predominantly expressed in the parvicellular subregion in mouse and rat (Gonzalez et al., 2012; Hauser et al., 1998; Laflamme et al., 1998; Lenkei et al., 1997; Milner et al., 2010) and colocalize with corticotropinreleasing factor in rat (Aguilera et al., 1995; Laflamme et al., 1998).”
BackgroundNeuroendocrinology of Body Fluid Homeostasis
Daniels, D., & Fluharty, S. J. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00007-3 · Cited by 34 · see citing works
Kang, Y., Yang, Q., Yu, X., Qi, J., Zhang, Y., Li, H., Su, Q., & Zhu, G. (2014) · Regenerative Medicine Research · doi:10.1186/2050-490x-2-2 · Cited by 28 · see citing works
“Previous studies have demonstrated that AT1-R is present in the PVN [15,17] and mRNA levels for the AT1 receptor are high in the PVN.”
Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat
Velkoska, E., Warner, F. J., Cole, T. J., Smith, A. I., & Morris, M. J. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.02.004 · Cited by 28 · see citing works
Anatomy of the Hypothalamo-Hypophysial Complex
Page, R. B. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50032-4 · Cited by 28 · see citing works
Shelat, S., Flanagan-Cato, L., & Fluharty, S. J. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1620381 · Cited by 28 · see citing works
Mulders, W. H. A. M., Meek, J., Hafmans, T. G. M., & Cools, A. R. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01663.x · Cited by 28 · see citing works
“…capacity of type I1 glucocorticoid receptors in the PVH (Reul et al., 1987), a decreased number of angiotensin receptors on CRH neurons (CastrCn and Saavedra, 1989; Aguilera et al., 1995) and a decrease in the number of a2-noradrenergic receptors in the PVH (Jhanwar-Uniyal and Leibowitz, 1986).”
BackgroundGABA is a mediator of brain AT1 and AT2 receptor-mediated blood pressure responses
Dupont, A. G., & Légat, L. (2020) · Hypertension Research · doi:10.1038/s41440-020-0470-9 · Cited by 27 · see citing works
“It has been proposed that AT1 receptors are localized to cells with neuronal [30, 38, 39] and non-”
BackgroundRegulation of the hypothalamic-pituitary-adrenal axis by neuropeptides
Aguilera, G. (2011) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2011.123 · Cited by 27 · see citing works
Self-citationOntogeny of angiotensin II type 1 receptor mRNAs in fetal and neonatal rat brain
Nuyt, A. M., Lenkei, Z., Corvol, P. L., Palkovits, M., & Llorens‐Cortés, C. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1379 · Cited by 26 · see citing works
“…by stimulating AT1 receptors (Veltmar et al., 1992; Tsushima et al., 1994; Johnson et al., 1996), and Ang II/III indirectly stimulates ACTH secretion by stimulating corticotropin-releasing hormone neurons located in the paraventricular nucleus (Ganong and Murakami, 1987; Aguilera et al., 1995).”
BackgroundSmith, J. A., Pati, D., Wang, L. A., de Kloet, A. D., Frazier, C. J., & Krause, E. G. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00046 · Cited by 25 · see citing works
“Stress-induced up-regulation of AT1 receptor mRNA occurs in the SFO, anterior pituitary, zona glomerulosa and medulla of the adrenal gland (Leong et al., 2002), and on CRF cells in the PVH (Aguilera et al., 1995b).”
BackgroundRoesch, D. M., Blackburn-Munro, R. E., & Verbalis, J. G. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1853 · Cited by 25 · see citing works
The intricacies of the renin-angiotensin-system in metabolic regulation
Bruce, E. B., & de Kloet, A. D. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.020 · Cited by 24 · see citing works
Cocaine, HIV, and their cardiovascular effects: is there a role for ACE-inhibitor therapy?
Margolin, A., Avants, S. K., Setaro, J. F., Rinder, H. M., & Grupp, L. A. (2000) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(00)00124-1 · Cited by 23 · see citing works
The Hypothalamic–Pituitary–Adrenal Axis and Neuroendocrine Responses to Stress
Aguilera, G. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10008-3 · Cited by 26 · see citing works
Self-citationHypothalamic-pituitary-adrenal axis up-regulation in rats submitted to pituitary stalk compression
Elias, P. C. L., Elias, L. L. K., de Castro, M., et al. (2004) · Journal of Endocrinology · doi:10.1677/joe.0.1800297 · Cited by 21 · see citing works
“In addition, we cannot rule out other factors such as angiotensin II and catecholamines as possible mediators of the increased activity of the HPA axis (Lightman & Young 1987, Harbuz et al. 1991, Aguilera et al. 1995).”
BackgroundSommer, W. H., Rimondini, R., Marquitz, M., Lidström, J., Siems, W. E., Bäder, M., & Heilig, M. A. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0255-5 · Cited by 20 · see citing works
Regulation of the Hypothalmic-Pituitary-Adrenal Axis and Vasopressin Secretion
Aguilera, G., & KISS, A. J. (1996) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-1376-0_11 · Cited by 20 · see citing works
Self-citationUnknown face of known drugs – what else can we expect from angiotensin converting enzyme inhibitors?
Wzgarda, A., Kleszcz, R., Prokop-Piotrkowska, M., Regulska, K., Regulski, M., Paluszczak, J., & Stanisz, B. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.12.031 · Cited by 19 · see citing works
Effect of chronic stress on the cardiac baroreflex in the post-weanling rat
Porter, J. P., Phillips, A. C., Rich, J. T., et al. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.03.018 · Cited by 19 · see citing works
Watanabe, T., Saiki, Y., & Sakata, Y. (1997) · PubMed · Cited by 19 · see citing works
Alegría-Herrera, E., Herrera-Ruiz, M. L., Román‐Ramos, R., Zamilpa, A., Santillan‐Urquiza, M. A., Aguilar, M. I., Avilés‐Flores, M., Fuentes‐Mata, M., & Jiménez‐Ferrer, E. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00574 · Cited by 18 · see citing works
Contribution of central ANG II to acute stress-induced changes in baroreflex function in young rats
Porter, J. P. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1386 · Cited by 18 · see citing works
Speth, R. C., Barry, W. T., Smith, M. S., et al. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.3.r904 · Cited by 17 · see citing works
Saavedra, J. M., & Pavel, J. (2005) · Drug Development Research · doi:10.1002/ddr.20027 · Cited by 16 · see citing works
Physiological regulation of brain angiotensin receptor mRNA in AT1a deficient mice
Rocha, M. J. A., Chen, Y., Oliveira, G. R., et al. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.05.011 · Cited by 16 · see citing works
Liu, Q., Wang, T., Yu, H., et al. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0159 · Cited by 14 · see citing works
Opioid and cocaine combined effect on cocaine-induced changes in HPA and HPG axes hormones in men
Goletiani, N. V., Mendelson, J. H., Sholar, M. B., Siegel, A. J., & Mello, N. K. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.09.007 · Cited by 12 · see citing works
“CRH release is in turn influenced by several systems/peptides, such as NPY, angiotensin II, and opioids (Aguilera et al., 1995; Dimitrov et al., 2007; Koenig, 1989; Suda et al., 1993).”
BackgroundБажанова, Е. Д., Chernigovskaya, E. V., & Danilova, O. A. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00135-4 · Cited by 12 · see citing works
Sladek, C. D., Michelini, L. C., Stachenfeld, N. S., Stern, J. E., & Urban, J. H. (2015) · Comprehensive physiology · doi:10.1002/j.2040-4603.2015.tb00634.x · Cited by 12 · see citing works
Jiang, N., Shi, P. D., Li, H., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134684 · Cited by 11 · see citing works
Romanov, R. A., & Harkany, T. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100366 · Cited by 10 · see citing works
Bali, A., & Jaggi, A. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.037 · Cited by 10 · see citing works
Visniauskas, B., Perry, J. C., Oliveira, V., Dalio, F. M., Andersen, M. L., Tufik, S., & Chagas, J. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.054 · Cited by 10 · see citing works
Review: AT1-receptors in the central nervous system
Allen, A. M., Giles, M., Lee, J., Oldfield, B. J., Mendelsohn, F. A. O., & McKinley, M. J. (2001) · Journal of the Renin-Angiotensin-Aldosterone System · doi:10.1177/14703203010020011701 · Cited by 10 · see citing works
AT(1)-receptors in the central nervous system
Allen, A. M., Giles, M., Lee, J., Oldfield, B. J., Mendelsohn, F. A. O., & McKinley, M. J. (2001) · Journal of the Renin-Angiotensin-Aldosterone System · Cited by 10 · see citing works
Ogundele, O. M., Lee, C. C., & Francis, J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13842 · Cited by 10 · see citing works
“Excitatory glutamatergic and inhibitory GABA neuron populations have also been identified in parts of the PVN where they control the release of neuropeptides (Ang II), Corticotropin-releasing hormone (CRH), and electrolyte balance (Aguilera et al. 1995a,b; Nillni 2010).”
Background
- Authors
- Aguilera, G., Young, W. S., Kiss, A., & Bathia, A.
- Affiliations
- National Institutes of Health (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2008-04-09
- Volume
- 61
- Issue
- 4
- Pages
- 437-444
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W1986221824
- Cited by
- 144
- References
- 0
- Citations by year
- 2022: 1 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- angiotensin II, corticotropin-releasing factor, hypothalamic paraventricular nucleus, angiotensin II type 1 receptor, vasopressin, hypothalamic-pituitary-adrenal axis, oxytocin, magnocellular neurons, parvicellular neurons, acute stress, hypertonic saline, supraoptic nucleus
- MeSH terms
- Angiotensin II, Animals, Autoradiography, Corticotropin-Releasing Hormone, Injections, Intraventricular, Male, Neurons, Paraventricular Hypothalamic Nucleus, Receptors, Angiotensin, RNA, Messenger, Tissue Distribution, Vasopressins, Rats, Sprague-Dawley, In Situ Hybridization, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
