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Promotion of IgA Immune Response in Patients with Crohn’s Disease by Oral Bacteriotherapy with Lactobacillus GG
Abstract
The effect of oral bacteriotherapy with human Lactobacillus casei strain GG (10(10) colony-forming units twice daily for 10 days) was investigated in Crohn's disease and in juvenile chronic arthritis which are chronic inflammatory diseases associated with impaired mucosal barrier function. During oral bacteriotherapy, the gut immune response was indirectly assessed by solid-phase enzyme-linked immunoassay in 14 children with Crohn's disease, in 9 with juvenile chronic arthritis, and in 7 controls. The immunostimulatory effect of Lactobacillus GG was specific for Crohn's disease, irrespective of its activity: the mean (95% confidence interval) number of specific antibody secreting cells in the IgA class to beta-lactoglobulin increased significantly from 0.2 (0.04-1.3) to 1.4 (0.3-6.0)/10(6) cells and to casein from 0.3 (0.1-1.4) to 1.0 (0.2-4.8)/10(6) cells. The results indicate that orally administered Lactobacillus GG has the potential to increase the gut IgA immune response and thereby to promote the gut immunological barrier. Consequently, Lactobacillus GG could provide an adjunct nutritional therapy for Crohn's disease.
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Cited by
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Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
Probiotics: effects on immunity
Isolauri, E., Sütas, Y., Kankaanpää, P., Arvilommi, H., & Salminen, S. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.444s · Cited by 1,019
Self-citationVenturi, Gionchetti, Rizzello, Johansson, Zucconi, Brigidi, Matteuzzi, & Campieri (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.00560.x · Cited by 567
Adolfsson, O., Meydani, S. N., & Russell, R. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.245 · Cited by 531
Gupta, P., Andrew, H., Kirschner, B. S., & Guandalini, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200010000-00024 · Cited by 429
Metadata
- Authors
- Malin, M., Suomalainen, H., Saxelin, M., & Isolauri, E.
- Venue
- Annals of Nutrition and Metabolism
- Publisher
- S. Karger AG
- Published
- 1996
- Volume
- 40
- Issue
- 3
- Pages
- 137-145
- ISSN
- 0250-6807 (ISSN-L)
- 1421-9697
- OpenAlex
- W2072646880
- Cited by
- 316
- References
- 0
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Promotion of IgA Immune Response in Patients with Crohn’s Disease by Oral Bacteriotherapy with Lactobacillus GG. https://app.cochat.ai/papers/10.1159/000177907
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- Malin, M., Suomalainen, H., Saxelin, M., & Isolauri, E. (1996). Promotion of IgA Immune Response in Patients with Crohn’s Disease by Oral Bacteriotherapy with Lactobacillus GG. Annals of Nutrition and Metabolism. https://doi.org/10.1159/000177907
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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