The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Is Lactobacillus GG Helpful in Children With Crohn’s Disease? Results of a Preliminary, Open-Label Study
Abstract
BACKGROUND: Lactobacillus GG is a safe probiotic bacterium known to transiently colonize the human intestine. It has been found to be useful in treatment of several gastrointestinal conditions characterized by increased gut permeability. In the current study, the efficacy of Lactobacillus GG was investigated in children with Crohn's disease. METHODS: In this open-label pilot evaluation viewed as a necessary preliminary step for a possible subsequent randomized placebo-controlled trial, four children with mildly to moderately active Crohn's disease were given Lactobacillus GG (10(10) colony-forming units [CFU]) in enterocoated tablets twice a day for 6 months. Changes in intestinal permeability were measured by a double sugar permeability test. Clinical activity was determined by measuring the pediatric Crohn's disease activity index. RESULTS: There was a significant improvement in clinical activity 1 week after starting Lactobacillus GG, which was sustained throughout the study period. Median pediatric Crohn's disease activity index scores at 4 weeks were 73% lower than baseline. Intestinal permeability improved in an almost parallel fashion. CONCLUSIONS: Findings in this pilot study show that Lactobacillus GG may improve gut barrier function and clinical status in children with mildly to moderately active, stable Crohn's disease. Randomized, double-blind, placebo-controlled trials are warranted for a final assessment of the efficacy of Lactobacillus GG in Crohn's disease.
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In humans, Lactobacillus casei GG improved symptoms in children with moderately active CD.
“In humans, Lactobacillus casei GG improved symptoms in children with moderately active CD (201).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [201]
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Metadata
- Authors
- Gupta, P., Andrew, H., Kirschner, B. S., & Guandalini, S.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Guandalini, Stefano
- Venue
- Journal of Pediatric Gastroenterology and Nutrition
- Publisher
- Wiley
- Published
- 2000-10
- Volume
- 31
- Issue
- 4
- Pages
- 453-457
- ISSN
- 0277-2116 (ISSN-L)
- OpenAlex
- W2050341344
- Cited by
- 429
- References
- 28
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 15 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 8 · 2019: 11 · 2018: 17 · 2017: 14 · 2016: 18 · 2015: 14 · 2014: 16 · 2013: 22 · 2012: 22
- FWCI
- 34.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Gastroenterology and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Lactobacillus rhamnosus GG, probiotics, Crohn's disease, pediatric inflammatory bowel disease, intestinal permeability, intestinal barrier, Pediatric Crohn's Disease Activity Index
- MeSH terms
- Adolescent, Child, Crohn Disease, Humans, Intestinal Mucosa, Lactobacillus, Male, Permeability, Pilot Projects, Tablets, Enteric-Coated, Time Factors, Probiotics
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