Bone Turnover in Overt and Subclinical Hyperthyroidism Due to Autonomous Thyroid Adenoma
Abstract
Parameters of bone turnover were measured in 20 premenopausal women affected by autonomous thyroid adenoma: 7 patients were suffering from overt hyperthyroidism with raised values of free thyroid hormones; 13 were clinically euthyroid and had normal values of free thyroid hormones. In all cases serum TSH concentrations were below the lower normal limit of our laboratory ( < 0.4 mU/l). Eleven healthy premenopausal women were studied as a control group. Patients with overt hyperthyroidism disclosed a significant enhancement of both bone resorption (increased serum calcium and urinary excretion of hydroxyproline) and bone formation (increased serum levels of osteocalcin and alkaline phosphatase) when compared both to controls and to patients with subclinical hyperthyroidism. No significant alterations of bone metabolism parameters were found in patients with subclinical hyperthyroidism in comparison with controls. Therefore, in premenopausal women affected by autonomous thyroid adenoma the bone turnover appeared to be significantly increased when the serum values of free thyroid hormones were raised in the group of patients with overt hyperthyroidism.
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- Authors
- De Menis, E., Da Rin, G., Roiter, I., Legovini, P., Foscolo, G., & Conte, N.
- ORCID
- Roiter, Ignazio
- Venue
- Hormone Research
- Publisher
- S. Karger AG
- Published
- 2008-12-03
- Volume
- 37
- Issue
- 6
- Pages
- 217-220
- ISSN
- 0301-0163 (ISSN-L)
- 1423-0046
- OpenAlex
- W2025244922
- Cited by
- 30
- References
- 0
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2017: 1 · 2015: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormone Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- bone turnover, hyperthyroidism, subclinical hyperthyroidism, autonomous thyroid adenoma, bone resorption, bone formation, osteocalcin, alkaline phosphatase, hydroxyproline, serum calcium, thyroid-stimulating hormone, premenopausal women, free thyroid hormones
- MeSH terms
- Adenoma, Adult, Alkaline Phosphatase, Bone and Bones, Calcium, Female, Humans, Hydroxyproline, Hyperthyroidism, Thyroid Hormones, Thyroid Neoplasms, Thyrotropin, Osteocalcin, Bone Remodeling
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