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Cited by 66Bone health and osteoporosis researchThyroid Disorders and TreatmentsBone Metabolism and Diseases

Reduced bone mass detected by bone quantitative ultrasonometry and DEXA in pre- and postmenopausal women with endogenous subclinical hyperthyroidism

Tauchmanovà, Libuse, Nuzzo, Vincenzo, Del Puente, Antonio, Fonderico, Francesco, Esposito-Del Puente, Antonella, Padulla, Stefania, Rossi, Annalisa, Bifulco, Giuseppe +2 more·2004·Maturitas
DOI 10.1016/j.maturitas.2004.02.017
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Abstract

Background Although overt hyperthyroidism is a well known cause of bone loss, systemic effects of subclinical hyperthyroidism (SH) are still a matter of debate.Objective The aim of this cross-sectional study was to evaluate the effect of endogenous SH on bone in relation to the menopausal status.Methods Bone mass and turnover were assessed in a group of 60 patients with endogenous SH due to multinodular goitre; 30 of them were premenopausal and 30 early postmenopausal (mean age, 40.9 +/- 7.3 and 57.7 +/- 6.75, respectively). Sixty healthy women matched for age-, BMI- and menopausal status served as controls. Three different skeletal sites were evaluated using two different techniques: lumbar spine and femoral neck were assessed by DEXA whereas the proximal phalanges were evaluated by quantitative ultrasonometry (QUS), measuring the amplitude-dependent speed of sound (Ad-SoS). Serum osteocalcin and urinary deoxypyridinoline (DPD) were also determined as markers of bone turnover.Results A significant decrease was found in femoral BMD (P < 0.05) and phalangeal Ad-SoS (P < 0.001) in pre- and postmenopausal patients compared to controls, being greater in those postmenopausal. Lumbar BMD was decreased only in postmenopausal patients (P < 0.05). Bone turnover markers were higher in patients than in controls and in post- than in the premenopausal ones. A significant negative correlation was found between femoral BMD, Ad-SoS and serum free T3 levels, the latter considered a marker of disease activity.Conclusions A significant increase in bone turnover markers and a decrease in bone mass was found in women affected by endogenous SH, being greater in early postmenopausal patients. Cortical rich bone was mainly affected. Both QUS and the conventional DEXA technique were equally able to determine bone density decrease related to mild thyroid hormone excess and sexual hormone decrease.

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Authors
Tauchmanovà, L., Nuzzo, V., Del Puente, A., Fonderico, F., Esposito-Del Puente, A., Padulla, S., Rossi, A., Bifulco, G., Lupoli, G., & Lombardi, G.
Affiliations
Federico II University Hospital (IT)
Corresponding author
Tauchmanovà, Libuse
ORCID
Venue
Maturitas
Publisher
Elsevier BV
Published
2004-07
Volume
48
Issue
3
Pages
299-306
ISSN
0378-5122 (ISSN-L)
DOI
10.1016/j.maturitas.2004.02.017
OpenAlex
W2132962816
Cited by
66
References
34
Citations by year
2026: 1 · 2025: 2 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 7 · 2013: 3 · 2012: 10
FWCI
2.28
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Maturitas (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords
subclinical hyperthyroidism, bone mass, bone turnover, menopause, postmenopausal women, multinodular goiter, amplitude-dependent speed of sound, bone mineral density, femoral neck, lumbar spine, cortical bone, osteocalcin, deoxypyridinoline, free T3, thyroid hormone excess
MeSH terms
Adult, Aged, Bone Resorption, Cross-Sectional Studies, Female, Femur Neck, Fingers, Humans, Hyperthyroidism, Lumbar Vertebrae, Middle Aged, Regression Analysis, Ultrasonography, Biomarkers, Absorptiometry, Photon, Bone Density, Case-Control Studies, Premenopause, Postmenopause

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