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Cited by 60Growth Hormone and Insulin-like Growth FactorsBone health and osteoporosis researchHypothalamic control of reproductive hormones

Impact of Aromatase Inhibitor Therapy on Bone Turnover, Cortical Bone Growth and Vertebral Morphology in Pre- and Peripubertal Boys with Idiopathic Short Stature

Hero, Matti, Mäkitie, Outi, Kröger, Heikki, Nousiainen, Elina, Toiviainen-Salo, Sanna, Dunkel, Leo·2009·Hormone Research in Paediatrics
DOI 10.1159/000208803
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Abstract

In this randomized placebo-controlled study we examined the influence of aromatase inhibition on bone turnover, cortical bone growth, and vertebral body morphology in peripubertal boys. Thirty peripubertal boys with idiopathic short stature were treated with the aromatase inhibitor letrozole or placebo for 2 years. During treatment and posttreatment follow-up, dual-energy X-ray absorptiometry (DXA)-assessed bone mineral density, metacarpal index (MCI), and markers of bone turnover were examined. Vertebral morphology was examined by DXA after cessation of treatment. In letrozole-treated boys, the concentrations of the bone resorption marker urine aminoterminal telopeptide of type I collagen initially increased and thereafter slowly declined while the concentrations of the bone formation markers serum aminoterminal propeptide of type I collagen and serum alkaline phosphatase remained unchanged or slightly increased, respectively. In placebo-treated boys, all markers of bone turnover increased significantly during treatment. Among those who progressed into puberty, metacarpal index (MCI) increased more in the letrozole-treated than in the placebo-treated boys during treatment (25 vs. 9%, p = 0.007). The change in MCI correlated with the testosterone-to-estradiol ratio (r = 0.59, p = 0.02). Vertebral deformities were detected in 6 out of 13 boys receiving letrozole and in 4 out of 11 receiving placebo (p = 0.70). Aromatase inhibition suppresses bone turnover, possibly through an androgen-mediated effect. In pubertal boys, treatment stimulates cortical bone growth by increasing the testosterone-to-estradiol ratio.

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  • One double-blind crossover trial using testolactone did not show a significant improvement of sperm quality in men with oligospermia.

    “However, one double-blind crossover trial using testolactone did not show a significant improvement of sperm quality in men with oligospermia [52].”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [52]

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Authors
Hero, M., Mäkitie, O., Kröger, H., Nousiainen, E., Toiviainen-Salo, S., & Dunkel, L.
Affiliations
  • University of Helsinki (FI)
  • Kuopio University Hospital (FI)
ORCID
Venue
Hormone Research in Paediatrics
Publisher
S. Karger AG
Published
2009
Volume
71
Issue
5
Pages
290-297
ISSN
  • 1663-2818 (ISSN-L)
  • 1663-2826
DOI
10.1159/000208803
OpenAlex
W1996337308
Cited by
60
References
32
Citations by year
2025: 3 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 1 · 2015: 7 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
5.57
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Hormone Research in Paediatrics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Lastentautien Tutkimussäätiö
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
aromatase inhibitors, letrozole, idiopathic short stature, bone turnover, vertebral deformity, metacarpal index, testosterone/estradiol ratio, bone mineral density, bone resorption markers
MeSH terms
Letrozole, Adolescent, Bone and Bones, Bone Development, Child, Estradiol, Fetal Proteins, Growth Disorders, Humans, Insulin-Like Growth Factor I, Male, Nitriles, Peptide Fragments, Peptides, Placebos, Procollagen, Testosterone, Triazoles, Absorptiometry, Photon, Bone Density, Collagen Type I, Aromatase Inhibitors

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