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Cited by 200Bone health and osteoporosis researchSexual Differentiation and DisordersEstrogen and related hormone effects

Estrogens Are Essential for Male Pubertal Periosteal Bone Expansion

Bouillon, Roger, Bex, Marie, Vanderschueren, Dirk, Boonen, Steven·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-0602
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Abstract

The skeletal response to estrogen therapy was studied in a 17-yr-old boy with congenital aromatase deficiency. As expected, estrogen therapy (1 mg estradiol valeriate/d from age 17 until 20 yr) normalized total and free testosterone and reduced the rate of bone remodeling. Dual-energy x-ray absorptiometry-assessed areal bone mineral density (BMD) of the lumbar spine and femoral neck increased significantly (by 23% and 14%, respectively), but peripheral quantitative computed tomography at the ultradistal radius revealed no gain of either trabecular or cortical volumetric BMD. The increase in areal BMD was thus driven by an increase in bone size. Indeed, longitudinal bone growth (height, +8.5%) and especially cross-sectional area of the radius (+46%) and cortical thickness (+12%), as measured by peripheral quantitative computed tomography, increased markedly during estrogen treatment. These findings demonstrate that androgens alone are insufficient, whereas estrogens are essential for the process of pubertal periosteal bone expansion typically associated with the male bone phenotype.

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Crossref · 10.1210/jc.2004-0602

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  • All adult aromatase-deficient men demonstrated a remarkably low bone mass.

    “All adult aromatase-deficient men demonstrated a remarkably low bone mass and unfused epiphyses leading to linear growth into adulthood and above-average body length.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [17]

  • Once treated with estradiol, epiphyses closed in most aromatase-deficient men.

    “Once treated with estradiol, epiphyses closed, BMD increased and disturbances in the lipid profile improved in most of these patients.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [17]

  • All adult aromatase-deficient men have unfused epiphyses leading to linear growth into adulthood and above-average body length.

    “All adult aromatase-deficient men demonstrated a remarkably low bone mass and unfused epiphyses leading to linear growth into adulthood and above-average body length.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [17]

  • Once treated with estradiol, disturbances in the lipid profile improved in most aromatase-deficient men.

    “Once treated with estradiol, epiphyses closed, BMD increased and disturbances in the lipid profile improved in most of these patients.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [17]

  • Once treated with estradiol, BMD increased in most aromatase-deficient men.

    “Once treated with estradiol, epiphyses closed, BMD increased and disturbances in the lipid profile improved in most of these patients.”

    From Aromatase inhibitors in men: effects and therapeutic options (2011) · cites this paper as [17]

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Authors
Bouillon, R., Bex, M., Vanderschueren, D., & Boonen, S.
Affiliations
KU Leuven (BE)
Corresponding author
Bouillon, Roger
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-12
Volume
89
Issue
12
Pages
6025-6029
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-0602
OpenAlex
W2090238137
Cited by
200
References
25
Citations by year
2025: 5 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 2 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 14 · 2012: 11
FWCI
11.20
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
estrogen, male puberty, estradiol valerate, bone mineral density, bone remodeling, bone growth, cortical thickness, androgens
MeSH terms
Adolescent, Aromatase, Bone Development, Estrogens, Femur Neck, Humans, Lumbar Vertebrae, Male, Periosteum, Puberty, Radius, Tomography, X-Ray Computed, Bone Density, Steroid Metabolism, Inborn Errors

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