The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Evaluation of Stress Systems by Applying Noninvasive Methodologies: Measurements of Neuroimmune Biomarkers in the Sweat, Heart Rate Variability and Salivary Cortisol
Abstract
The two main arms of the stress system include the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis. These two neural stress systems coordinate the response of many other physiological systems to a stressor, including the immune and cardiovascular systems, bringing the body back to homeostasis. The nervous and immune systems communicate with each other in a bidirectional manner. In this review, we will discuss the use of noninvasive methods to evaluate the immune system, ANS and HPA axis. Collection of sweat and saliva, and measurement of heart rate variability are noninvasive methods that can be applied to evaluate neuroimmune interactions. Recently, we validated a new methodology to simultaneously evaluate a large array of neural and immune biomarkers in sweat, collected through cutaneous sweat patches and measured by recycling immunoaffinity chromatography. Noninvasive and ambulatory methodologies of biomarker collection can overcome several limitations intrinsic to invasive methods, such as reducing the stress triggered by collection itself and allowing a wider application to field and community-based settings. Ultimately, simultaneous evaluation of neural and immune systems with noninvasive techniques will help elucidate the underlying interactions of these systems and their role in disease susceptibility and progression of stress-related disorders.
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“Psychological stress triggers a cascade of pathophysiological events mediated by the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal (HPA) axis (14, 15).”
From Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction (2023) · cites this paper as [14]
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“These two neural stress systems coordinate the responses of many other physiological systems to stressors, including the immune and cardiovascular systems, allowing the body to return to homeostasis (14).”
From Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction (2023) · cites this paper as [14]
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Cites
Physiology and immunology of the cholinergic antiinflammatory pathway
Tracey, K. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30555 · Cited by 1,563
Neuroendocrine Regulation of Immunity
Webster, J. I., Tonelli, L., & Sternberg, E. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.082401.104914 · Cited by 957
Self-citationImmune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506 · cited 1×
“Two main pathways by which psychological stress is relayed to the body are the hypothalamic-pituitary-adrenal (HPA) axis (neuroendocrine route, resultant release of glucocorticoids – cortisol) and the sympathetic nervous system (SNS, neural route, resultant release of catecholamines – noradrenaline/adrenaline – and ne…”
BackgroundSelf-citationCizza, G., Marques, A. H., Eskandari, F., Christie, I. C., Torvik, S., Silverman, M. N., Phillips, T. M., & Sternberg, E. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.035 · Cited by 208
Self-citationMarques-Deak, A., Cizza, G., Eskandari, F., Torvik, S., Christie, I. C., Sternberg, E. M., & Phillips, T. M. (2006) · Journal of Immunological Methods · doi:10.1016/j.jim.2006.07.011 · Cited by 129
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Research works printed but not linked: 4
- 10.1038%2Fnri1810 · DOI · Paper page
- 10.1016%2FS0165-022X%2801%2900202-0 · DOI
- 10.3949%2Fccjm.76.s2.05 · DOI
- 10.1016%2Fj.ijpsycho.2008.03.014 · DOI · Paper page
Cited by
Stress and Heart Rate Variability: A Meta-Analysis and Review of the Literature
Kim, H.-G., Cheon, E.-J., Bai, D.-S., Lee, Y. H., & Koo, B.-H. (2018) · Psychiatry Investigation · doi:10.30773/pi.2017.08.17 · Cited by 2,308
Salivary Alpha-Amylase as a Biomarker of Stress in Behavioral Medicine
Ali, N., & Nater, U. M. (2020) · International Journal of Behavioral Medicine · doi:10.1007/s12529-019-09843-x · Cited by 304
Visual Schedule System in Dental Care for Patients with Autism: A Pilot Study
Mah, J. W., & Tsang, P. (2016) · Journal of Clinical Pediatric Dentistry · doi:10.17796/1053-4628-40.5.393 · Cited by 56
Pathophysiology of Major Depression by Clinical Stages
de Menezes Galvão, A. C., Almeida, R. N., de Sousa, G. M., Leocadio-Miguel, M. A., Palhano-Fontes, F., de Araujo, D. B., Lobão-Soares, B., Maia-de-Oliveira, J. P., Nunes, E. A., Hallak, J. E. C., et al. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.641779 · Cited by 31
Xu, J., Chen, Y., Gu, L., Liu, X., Yang, J., Li, M., Rao, K., Dong, X., Yang, S., Huang, B., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1103621 · Cited by 13
Metadata
- Authors
- Marques, A. H., Silverman, M. N., & Sternberg, E. M.
- Venue
- Neuroimmunomodulation
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 17
- Issue
- 3
- Pages
- 205-208
- ISSN
- 1021-7401
- 1423-0216
- Cited by
- 139
- References
- 5
- Language
- en
- Licence
- www.karger.com/Services/SiteLicenses (vor)
- www.karger.com/Services/SiteLicenses (tdm)
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- Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2010). Evaluation of Stress Systems by Applying Noninvasive Methodologies: Measurements of Neuroimmune Biomarkers in the Sweat, Heart Rate Variability and Salivary Cortisol. Neuroimmunomodulation. https://doi.org/10.1159/000258725
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