The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Neutrophil Apoptosis: Relevance to the Innate Immune Response and Inflammatory Disease
Open accessAbstract
Neutrophils are the most abundant cell type involved in the innate immune response. They are rapidly recruited to sites of injury or infection where they engulf and kill invading microorganisms. Neutrophil apoptosis, the process of programmed cell death that prevents the release of neutrophil histotoxic contents, is tightly regulated and limits the destructive capacity of neutrophil products to surrounding tissue. The subsequent recognition and phagocytosis of apoptotic cells by phagocytic cells such as macrophages is central to the successful resolution of an inflammatory response and it is increasingly apparent that the dying neutrophil itself exerts an anti-inflammatory effect through modulation of surrounding cell responses, particularly macrophage inflammatory cytokine release. Apoptosis may be delayed, induced or enhanced by micro-organisms dependent on their immune evasion strategies and the health of the host they encounter. There is now an established field of research aimed at understanding the regulation of apoptosis and its potential as a target for therapeutic intervention in inflammatory and infective diseases. This review focuses on the physiological regulation of neutrophil apoptosis with respect to the innate immune system and highlights recent advances in mechanistic understanding of apoptotic pathways and their therapeutic manipulation in appropriate and excessive innate immune responses.
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“Apoptosis and the subsequent phagocytosis of apoptotic cells is central to successful resolution of inflammation and there is significant research interest in targeting apoptosis as a means to treat neutrophil-dominant, inflammatory diseases [”
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Carr, A., & Maggini, S. (2017) · Nutrients · doi:10.3390/nu9111211 · Cited by 2,035
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900
Selders, G. S., Fetz, A. E., Radic, M. Z., & Bowlin, G. L. (2017) · Regenerative Biomaterials · doi:10.1093/rb/rbw041 · Cited by 538
Neutrophils: important contributors to tumor progression and metastasis
Swierczak, A., Mouchemore, K. A., Hamilton, J. A., & Anderson, R. L. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9594-9 · Cited by 220
Bozonet, S. M., & Carr, A. C. (2019) · Nutrients · doi:10.3390/nu11061363 · Cited by 63
Metadata
- Authors
- Fox, S., Leitch, A. E., Duffin, R., Haslett, C., & Rossi, A. G.
- Venue
- Journal of Innate Immunity
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 2
- Issue
- 3
- Pages
- 216-227
- ISSN
- 1662-811X (ISSN-L)
- 1662-8128
- OpenAlex
- W2023374319
- Cited by
- 441
- References
- 78
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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