Association between APOE ε4 Allele and Vascular Dementia: The Cache County Study
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Background: The APOE Ε4 allele is an established risk factor for Alzheimer’s disease, but reports of its association with vascular dementia (VaD) have been inconsistent. We examined the relationship between APOE Ε4 allele and the risk of incident VaD in a large, population-based cohort of elderly adults with up to 10 years of follow-up between 1995 and 2005. Methods: A total of 3,424 elderly men and women free of dementia were genotyped at the baseline assessment. Incident VaD was identified through standardized procedures administered at 3 follow-up assessments. Cox proportional hazards models were used to evaluate the risk of VaD associated with APOE Ε4. Results: The adjusted hazard ratio was 1.6 for the participants with 1 APOE Ε4 allele (95% CI: 0.9–2.7; p = 0.083) and 4.4 for those with 2 APOE Ε4 alleles (95% CI: 1.6–12.5; p = 0.005). The increased risk did not appear to be mediated by vascular risk factors. Conclusions: The APOE Ε4 allele is associated with an increased risk of VaD in a dose-dependent fashion and accounts for almost 20% of VaD in the population.
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The ε4 allele plays a role in vascular dementia.
“ε4 also plays a role in vascular dementia [21][22][23][24][25][26]”
From APOE and vascular disease: Sequencing and genotyping in general population cohorts (2023) · cites this paper as [24]
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- Authors
- Chuang, Y.-F., Hayden, K. M., Norton, M. C., Tschanz, J., Breitner, J. C. S., Welsh-Bohmer, K. A., Zandi, P. P., & for the Cache County Investigators
- Affiliations
- Johns Hopkins University (US)
- Duke Medical Center (US)
- Utah State University (US)
- University of Washington (US)
- ORCID
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 29
- Issue
- 3
- Pages
- 248-253
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- PMC
- PMC2865397
- OpenAlex
- W2028363611
- Cited by
- 81
- References
- 3
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 4
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Utah State University
- National Institute on Aging (R01 AG 11380, R01AG011380)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- APOE ε4, vascular dementia, genetic risk factors, dose-dependent risk, incident dementia, vascular risk factors, older adults
- MeSH terms
- Aged, Cognition, Female, Gene Frequency, Genotype, Humans, Longitudinal Studies, Male, Middle Aged, Psychiatric Status Rating Scales, Risk Factors, Utah, Vascular Diseases, Dementia, Vascular, Proportional Hazards Models, Survival Analysis, Gene Dosage, Kaplan-Meier Estimate, Apolipoprotein E4
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