The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects
Open accessAbstract
The monovalent cation lithium partially exerts its effects by activating neurotrophic and neuroprotective cellular cascades. Here, we discuss the effects of lithium on oxidative stress, programmed cell death (apoptosis), inflammation, glial dysfunction, neurotrophic factor functioning, excitotoxicity, and mitochondrial stability. In particular, we review evidence demonstrating the action of lithium on cyclic adenosine monophosphate (cAMP)-mediated signal transduction, cAMP response element binding activation, increased expression of brain-derived neurotrophic factor, the phosphatidylinositide cascade, protein kinase C inhibition, glycogen synthase kinase 3 inhibition, and B-cell lymphoma 2 expression. Notably, we also review data from clinical studies demonstrating neurotrophic effects of lithium. We expect that a better understanding of the clinically relevant pathophysiological targets of lithium will lead to improved treatments for those who suffer from mood as well as neurodegenerative disorders.
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Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
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Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study
Zarate, C. A., Singh, J. B., Carlson, P. J., Quiroz, J., Jolkovsky, L., Luckenbaugh, D. A., & Manji, H. K. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00530.x · Cited by 208
Self-citationAngelucci, F., Aloe, L., Jiménez-Vasquez, P., & Mathé, A. A. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003468 · Cited by 157
Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium
Fornai, F., Longone, P., Ferrucci, M., Lenzi, P., Isidoro, C., Ruggieri, S., & Paparelli, A. (2008) · Autophagy · doi:10.4161/auto.5923 · Cited by 111
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Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867
The quest to slow ageing through drug discovery
Partridge, L., Fuentealba, M., & Kennedy, B. K. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0067-7 · Cited by 468
Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399
Calcium signalling remodelling and disease
Berridge, M. J. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110766 · Cited by 391
Metadata
- Authors
- Quiroz, J. A., Machado-Vieira, R., Zarate, Jr., & Manji, H. K.
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2010
- Volume
- 62
- Issue
- 1
- Pages
- 50-60
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W1969942100
- Cited by
- 226
- References
- 5
- FWCI
- 11.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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