The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review
Open accessAbstract
Arterial stiffening is a progressive, ubiquitous and irreversible aging process that is interwoven with and accelerated by various diseases such as diabetes, atherosclerosis and hypertension. In large arteries, aging is characterized by decreased turnover of collagen and elastin and increased advanced glycation end-products (AGEs) and cross-links. Elastic fibers undergo lysis and disorganization subsequent to their replacement by collagen and other matrix components. These events cause the loss of elasticity and induce stiffening. Conceptual approaches to minimize AGE accumulation in arteries include caloric restriction, exercise, low dietary intake of AGEs, deglycation enzymes, increased clearance of AGEs, antagonists of AGE receptors and pharmaceutical interventions. Much optimism exists in the ability of ‘AGE breakers’ such as alagebrium (ALT-711) to cleave AGE cross-links and reverse the age-related stiffening of arteries. However, there is little evidence that these agents actually break pre-existing AGE cross-links in vivo. In contrast, many of these anti-AGE agents share in common the ability to chelate metals, thus acting as inhibitors of metal-catalyzed AGE and protein carbonyl formation. Future work on interventions into the causes of arterial stiffness in aging needs to address more rigorously the relationship between stochastic forms of damage, such a glycation and oxidation, and the changes in elastic fiber structure thought to contribute to loss of arterial elasticity.
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Cites
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Cited by
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Age-related vascular stiffening: causes and consequences
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“Amino groups on proteins react with aldehydes or ketones on the reducing sugars to form shift bases that rearrange to Amadori products and are further modified to produce AGEs (Bakris et al., 2004; Sell and Monnier, 2012).”
BackgroundAging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
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The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases
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BackgroundPostprandial glucose spikes, an important contributor to cardiovascular disease in diabetes?
Hanssen, N. M. J., Kraakman, M. J., Flynn, M. C., Nagareddy, P. R., Schalkwijk, C. G., & Murphy, A. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.570553 · Cited by 90
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Ethnic differences regarding arterial stiffness of 6‐8‐year-old black and white boys
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Metadata
- Authors
- Sell, D. R., & Monnier, V. M.
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 58
- Issue
- 3
- Pages
- 227-237
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W1989364717
- Cited by
- 282
- References
- 2
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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