Single Umbilical Artery: Does Side Matter?
Open accessAbstract
Introduction: The aim of this study was to determine if laterality of an absent umbilical artery (AUA) is associated with specific sonographic findings, chromosomal defects or postpartum birth defects. Materials and Methods: In this retrospective cohort study, ultrasound reports and medical records of patients who received an obstetric ultrasound at the University of Iowa Hospitals and Clinics with an identified laterality of the AUA from 1989 to 2007 (n = 405) were reviewed. Rates of sonographic abnormalities between fetuses with a right versus left AUA were compared using Fisher’s exact test. Adjustments for confounding were made using logistic regression modeling. The significance level was set at 0.05. Results: Right AUAs on ultrasound demonstrate higher unadjusted rates of ultrasound abnormalities with a higher percentage of fetuses with >1 additional abnormality (51.1 vs. 37.0%; p = 0.0043). The left AUA group had a significantly higher percentage of isolated AUA (63.0 vs. 48.8%; p = 0.004). In a multivariate analysis, a sonographic right AUA was significantly associated with gastrointestinal (GI) and genitourinary (GU) abnormalities. No other ultrasonographic and umbilical artery Doppler abnormalities, chromosomal defects or postpartum birth defects were significantly associated with a specific laterality of the AUA. Discussion: Our study identified a significant association between a right AUA and concomitant fetal GI and GU abnormalities. Contrary to previous reports, we conclude that laterality of the AUA may prove to be an easily identified early marker of fetal abnormalities.
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Single umbilical artery is the result of obliteration or atrophy of one of the arteries, most commonly the left.
“Single umbilical artery (SUA) is the result of obliteration or atrophy of one of the arteries, most commonly the left 48 .”
From <scp>ISUOG</scp> Practice Guidelines (updated): performance of the routine mid‐trimester fetal ultrasound scan (2022) · cites this paper as [48]
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- Authors
- Santillan, M., Santillan, D., Fleener, D., Stegmann, B., Zamba, G., Hunter, S., & Yankowitz, J.
- Affiliations
- University of Iowa (US)
- University of South Florida (US)
- Venue
- Fetal Diagnosis and Therapy
- Publisher
- S. Karger AG
- Published
- 2012
- Volume
- 32
- Issue
- 3
- Pages
- 201-208
- ISSN
- 1015-3837 (ISSN-L)
- 1421-9964
- PMC
- PMC7347210
- OpenAlex
- W2113601137
- Cited by
- 15
- References
- 26
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Fetal Diagnosis and Therapy (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL007121)
- National Institute of Allergy and Infectious Diseases (T32 AI07260-22, T32AI007260)
- National Center for Research Resources (KL2RR024980, KL2 RR024980-2)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD000849)
- Topics
- Health Sciences › Medicine › Surgery › Congenital Anomalies and Fetal Surgery
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Developmental Biology › Congenital limb and hand anomalies
- Keywords
- single umbilical artery, laterality, fetal ultrasound abnormalities, gastrointestinal anomalies, genitourinary anomalies, chromosomal abnormalities, umbilical artery Doppler, prenatal screening markers
- MeSH terms
- Abnormalities, Multiple, Adult, Female, Hospitals, University, Humans, Iowa, Medical Records, Outpatient Clinics, Hospital, Pregnancy, Retrospective Studies, Umbilical Arteries, Urogenital Abnormalities, Cohort Studies, Biomarkers, Logistic Models, Ultrasonography, Prenatal, Ultrasonography, Doppler, Color, Gastrointestinal Tract, Single Umbilical Artery
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