The amniotic fluid index in normal human pregnancy
Abstract
The four-quadrant sum of amniotic fluid pockets (amniotic fluid index) was studied prospectively in 791 normal pregnancies. Interobserver and intraobserver variation was 3.1% and 6.7%, respectively. Logarithmic transformations were used to establish the mean and 90% confidence intervals for the amniotic fluid index at each week of gestation. In term pregnancies, the boundaries of the amniotic fluid index were 115 mm (mean), 68 to 196 mm (5th to 95th percentiles). In postdates pregnancies greater than 42 weeks, the values were 108 mm (mean), 67 to 174 mm (5th to 95th percentiles), p less than 0.0001. However, the values for each week were statistically distinct, indicating the need to reference amniotic fluid index measurements to week-specific normative tables for accurate interpretation. This study provides normative data for the amniotic fluid index throughout pregnancy.
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With AFI, the threshold for polyhydramnios is generally considered to be 24 cm or 25 cm, depending on whether a 95th or 97th percentile is selected.
“With AFI, the threshold is generally considered to be 24 cm or 25 cm, depending on whether a 95th or 97th percentile is selected.17,20”
From SMFM Consult Series #46: Evaluation and management of polyhydramnios (2018) · cites this paper as [20]
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- Authors
- Moore, T. R., & Cayle, J. E.
- Affiliations
- Naval Medical Center San Diego (US)
- Corresponding author
- Cayle, Jonathan E.
- ORCID
- Moore, Thomas R.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 162
- Issue
- 5
- Pages
- 1168-1173
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1971745316
- Cited by
- 554
- References
- 22
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 18 · 2022: 15 · 2021: 19 · 2020: 19 · 2019: 14 · 2018: 16 · 2017: 24 · 2016: 13 · 2015: 19 · 2014: 21 · 2013: 26 · 2012: 18
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- amniotic fluid index, amniotic fluid volume, normal pregnancy, reference values, gestational age, postdate pregnancy, term pregnancy, interobserver variability, intraobserver variability
- MeSH terms
- Amniotic Fluid, Cross-Sectional Studies, Female, Gestational Age, Humans, Pregnancy, Pregnancy, Prolonged, Prospective Studies, Reference Values, Regression Analysis, Ultrasonography, Observer Variation
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