Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic sh-Sy5y cells
Abstract
BACKGROUND AND AIMS: A recent neuroimaging study discovered the neurotoxicity effects of homocysteine (Hcy), which is only seen in elderly women. Estrogens exert a variety of actions on brain function that influence cognitive function, mood, and neuroprotection. The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant defense pathway has been well-known to afford neuroprotection. Here, we first demonstrate the roles of Nrf2-Keap1 in 17β-estradiol (E2) cytoprotection and Hcy toxicity and the protective mechanisms of E2 on Hcy cytotoxicity in human dopaminergic SH-SY5Y cells. METHODS: Cell viability was determined by trypan blue method. Protein expression was determined by Western blot analysis. Superoxide dismutase (SOD) activity was determined by ELISA. Reactive oxygen species (ROS) production was determined by flow cytometry. RESULTS: In Hcy-treated SH-SY5Y cells, E2 increased cell viability, attenuated ROS production, activated Akt signaling and inhibited glycogen synthase kinase-3β (GSK-3β), a kinase known to participate in neurodegeneration. Moreover, E2 treatment led to Nrf2 dissociation from Keap1, the main negative regulator of Nrf2 activity in the cytoplasm, and increased the protein level of Nrf2 in the nucleus, with a significant increase in HO-1 expression and SOD activity in Hcy-treated cells. E2-induced Nrf2 activation was attenuated by the PI3K inhibitor LY294002 and the estrogen receptor antagonist ICI 182,780. Further, E2 decreased Hcy-induced apoptotic death by upregulating the antiapoptotic protein Bcl-2, decreasing cytochrome c release from mitochondria, and attenuating apoptotic cascade activation (Bax, caspase-9, and caspase-3). CONCLUSION: E2 activates cell survival signaling and Nrf2-Keap1 antioxidant defense pathway and attenuates Hcy cytotoxicity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
17β-estradiol regulates multiple other aspects of mitochondrial function through ERs, including ROS generation, antioxidant defense, and Ca2+ handling.
“Moreover, 17β-estradiol also appears to regulate multiple other aspects of mitochondrial function through ERs, including ROS generation, antioxidant defense, and Ca2+ handling (126–131).”
From From mitochondria to sarcopenia: role of 17β-estradiol and testosterone (2023) · cites this paper as [128]
Cites
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W. F., & Wolf, P. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011613 · Cited by 3,237 · see citing works
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
Nguyen, T., Nioi, P., & Pickett, C. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r900010200 · Cited by 2,655 · see citing works
Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947 · see citing works
García‐Segura, L. M., Azcoitia, Í., & DonCarlos, L. L. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00025-3 · Cited by 938 · see citing works
Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., & Mattson, M. P. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06920.2000 · Cited by 784 · see citing works
Invited Review: Estrogens effects on the brain: multiple sites and molecular mechanisms
McEwen, B. S. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.6.2785 · Cited by 653 · see citing works
17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro
Behl, C., Widmann, M., Trapp, T., & Holsboer, F. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2647 · Cited by 608 · see citing works
Estrogen Prevents the Lipopolysaccharide-Induced Inflammatory Response in Microglia
Vegeto, E., Bonincontro, C., Pollio, G., Sala, A., Viappiani, S., Nardi, F., Brusadelli, A., Viviani, B., Ciana, P., & Maggi, A. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01809.2001 · Cited by 474 · see citing works
Yang, C., Zhang, X., Fan, H., & Liu, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.009 · Cited by 444 · see citing works
Bjelland, I., Tell, G., Vollset, S., Refsum, H., & Ueland, P. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.6.618 · Cited by 402 · see citing works
Ho, P. I., Ortiz, D., Rogers, E. J., & Shea, T. B. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10416 · Cited by 381 · see citing works
Transcriptional Regulation of the Heme Oxygenase-1 Gene Via the Stress Response Element Pathway
Alam, J., & Cook, J. L. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033453730 · Cited by 315 · see citing works
Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.
McEwen, B. S., Akama, K. T., Spencer-Segal, J. L., Milner, T. A., & Waters, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0026708 · Cited by 302 · see citing works
Behl, C., & Moosmann, B. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00883-3 · Cited by 301 · see citing works
Ischemic stroke in the elderly: an overview of evidence
Chen, R. L., Balami, J. S., Esiri, M. M., Chen, L., & Buchan, A. M. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.36 · Cited by 296 · see citing works
Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite
Sies, H., & Masumoto, H. (1996) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60986-2 · Cited by 230 · see citing works
Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes
Collins, A. R., Lyon, C. J., Xia, X., Liu, J. Z., Tangirala, R. K., Yin, F., Boyadjian, R., Bikineyeva, A. T., Praticò, D., Harrison, D. G., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.188771 · Cited by 214 · see citing works
Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke
Alfieri, A., Srivastava, S., Siow, R. C. M., Modo, M., Fraser, P. A., & Mann, G. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210294 · Cited by 198 · see citing works
Cardona‐Gómez, G. P., Pérez, M., Ávila, J., García‐Segura, L. M., & Wandosell, F. G. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.008 · Cited by 196 · see citing works
Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells
Sheng-kai, Y., Chang, T., Wang, H., Wu, L., Wang, R., & Meng, Q. H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.10.058 · Cited by 187 · see citing works
Cheng, X., Siow, R. C. M., & Mann, G. E. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3283 · Cited by 181 · see citing works
Association of Plasma Total Homocysteine Levels With Subclinical Brain Injury
Seshadri, S. S., Wolf, P. A., Beiser, A., Selhub, J., Au, R., Jacques, P. F., Yoshita, M., Rosenberg, I. H., D’Agostino, R. B., & DeCarli, C. S. (2008) · Archives of Neurology · doi:10.1001/archneur.65.5.642 · Cited by 176 · see citing works
Neuroprotective and Neurotrophic Efficacy of Phytoestrogens in Cultured Hippocampal Neurons
Zhao, L., Chen, Q., & Brinton, R. D. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700716 · Cited by 171 · see citing works
Mitochondria as Therapeutic Targets of Estrogen Action in the Central Nervous System
Nilsen, J., & Brinton, R. D. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337193 · Cited by 166 · see citing works
Homocysteine and Redox Signaling
Zou, C.-G., & Banerjee, R. V. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.547 · Cited by 148 · see citing works
Yu, X., Rajala, R. V. S., McGinnis, J. F., Li, F., Anderson, R. E., Yan, X., Li, S., Elias, R. V., Knapp, R. R., Zhou, X., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313283200 · Cited by 143 · see citing works
Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke
Li, J., Siegel, M., Yuan, M., Zeng, Z., Finnucan, L., Persky, R., Hurn, P. D., & McCullough, L. D. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.181 · Cited by 136 · see citing works
Homocysteine, cerebrovascular disease and brain atrophy
Sachdev, P. S. (2004) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2004.09.006 · Cited by 101 · see citing works
Kenchappa, R. S., Diwakar, L., Jayasree Annepu, B., & Ravindranath, V. (2004) · The FASEB Journal · doi:10.1096/fj.03-1075fje · Cited by 82 · see citing works
Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice
Duan, W., Zhang, R., Guo, Y., Jiang, Y., Huang, Y., Jiang, H., & Li, C. (2009) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-009-9194-5 · Cited by 75 · see citing works
Tjiattas, L., Ortiz, D., Dhivant, S., Mitton, K., Rogers, E. J., & Shea, T. B. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00086.x · Cited by 73 · see citing works
Hydrogen sulfide antagonizes homocysteine-induced neurotoxicity in PC12 cells
Tang, X., Shen, X., Huang, Y.-E., Ren, Y., Chen, R., Hu, B., He, J., Yin, W., Xu, J., & Jiang, Z.-S. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.07.2039 · Cited by 58 · see citing works
Homocysteine promotes proliferation and activation of microglia
Zou, C., Zhao, Y., Gao, S., Li, S., Cao, X.-Z., Zhang, M., & Zhang, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.11.007 · Cited by 57 · see citing works
Chen, C., Tsai, J., Tsang, H., Kuo, Y., Lin, H., Chiang, I., & Devanand, D. P. (2005) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200510000-00006 · Cited by 44 · see citing works
Role of Insulin-Like Growth Factors in Neuronal Plasticity and Neuroprotection
Torres‐Alemán, I. (2005) · Advances in experimental medicine and biology · doi:10.1007/0-387-26274-1_10 · Cited by 40 · see citing works
Park, Y., Jang, Y., & Kwon, Y. H. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.1069 · Cited by 40 · see citing works
Park, Y., Jang, Y., & Kwon, Y. H. (2010) · Amino Acids · doi:10.1007/s00726-010-0523-5 · Cited by 33 · see citing works
Homocysteine, Folate Deficiency, and Parkinson's Disease
Miller, J. W. (2002) · Nutrition Reviews · doi:10.1301/002966402320964089 · Cited by 31 · see citing works
Role of ERβ and GPR30 in the endocrine pancreas: A matter of estrogen dose.
Ropero, A. B., Pang, Y., Alonso-Magdalena, P., Thomas, P., & Nadal, A. (2012) · Steroids · doi:10.1016/j.steroids.2012.01.015 · Cited by 30 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Meng, X., Wang, M., Wang, X., Sun, G., Ye, J., Xu, H., & Sun, X. (2014) · Free Radical Research · doi:10.3109/10715762.2014.911853 · Cited by 106 · see citing works
Estrogen increases Nrf2 activity through activation of the PI3K pathway in MCF-7 breast cancer cells
Wu, J., Williams, D. M., Walter, G. A., Thompson, W. E., & Sidell, N. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.08.030 · Cited by 95 · see citing works
Cook, K. L., Clarke, P. A. G., Parmar, J. H., Hu, R., Schwartz‐Roberts, J. L., Abu-Asab, M. S., Wärri, A. M., Baumann, W. T., & Clarke, R. C. (2014) · The FASEB Journal · doi:10.1096/fj.13-247353 · Cited by 88 · see citing works
BRCA1 And Estrogen/Estrogen Receptor In Breast Cancer: Where They Interact?
Wang, L., & Di, L. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.8579 · Cited by 82 · see citing works
Zhu, C., Wang, S., Wang, B., Du, F., Hu, C., Li, H., Feng, Y., Zhu, R., Mo, M., Cao, Y., et al. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.057 · Cited by 76 · see citing works
Tiberi, J., Cesarini, V., Stefanelli, R., Canterini, S., Fiorenza, M. T., & Rosa, P. L. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111802 · Cited by 73 · see citing works
Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis
Marques, A. A., Bevilaqua, M. C. D. N., da Fonseca, A. M. P., Nardi, A. E., Thuret, S., & Dias, G. P. (2016) · Neural Plasticity · doi:10.1155/2016/5026713 · Cited by 78 · see citing works
Chen, J., Huang, Y., Hu, X., Bian, X., & Nian, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16073 · Cited by 60 · see citing works
Chen, J., Zhao, R., Wang, Y., Han, X., Lin, W. Y., Diao, M., He, S., Mei, P., & Liao, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-023-00763-x · Cited by 58 · see citing works
Bourgonje, A. R., Abdulle, A. E., Al-Rawas, A. M., Al‐Maqbali, M., Al-Saleh, M., Enriquez, M. B., Al‐Siyabi, S., Al-Hashmi, K., Al‐Lawati, I., Bulthuis, M. L. C., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010314 · Cited by 58 · see citing works
From mitochondria to sarcopenia: role of 17β-estradiol and testosterone
Tian, X., Lou, S., & Shi, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156583 · Cited by 54 · see citing works
Supraphysiologic-dose anabolic–androgenic steroid use: A risk factor for dementia?
Kaufman, M. J., Kanayama, G., Hudson, J. I., & Pope, H. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.02.014 · Cited by 54 · see citing works
Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease
Ruszkiewicz, J. A., Miranda‐Vizuete, A., Tinkov, A. A., Геннадиевна, С. М., Skalny, A. V., Tsatsakis, A. M., & Aschner, M. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1241-9 · Cited by 47 · see citing works
Panieri, E., & Saso, L. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8146 · Cited by 46 · see citing works
Darawsha, A., Trachtenberg, A., Levy, J., & Sharoni, Y. (2021) · Antioxidants · doi:10.3390/antiox10122023 · Cited by 44 · see citing works
Pellegrini, G., Cregor, M. D., McAndrews, K., Morales, C. C., McCabe, L. D., McCabe, G. P., Peacock, M., Burr, D. B., Weaver, C. M., & Bellido, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171161 · Cited by 42 · see citing works
17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells
Son, H. J., Kim, N., Song, C., Lee, S. M., Lee, H.-N., & Surh, Y. (2018) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2018.098 · Cited by 37 · see citing works
Haghani, A., Cacciottolo, M., Doty, K. R., D’Agostino, C., Thorwald, M. A., Safi, N., Levine, M. E., Sioutas, C., Town, T., Forman, H. J., et al. (2020) · eLife · doi:10.7554/elife.54822 · Cited by 37 · see citing works
McFarland, K., Price, D. L., Davis, C. N., Ma, J., Bonhaus, D. W., Burstein, E. S., & Olsson, R. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400132u · Cited by 36 · see citing works
Folic acid inhibits homocysteine-induced cell apoptosis in human umbilical vein endothelial cells
Cui, S., Li, W., Wang, P., Lv, X., Gao, Y., & Huang, G. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3232-5 · Cited by 34 · see citing works
Wang, L., Yokoyama, K. K., Lin, C., Chen, T.-Y., Hsiao, H.-W., Chiang, P.-C., & Hsu, C. (2016) · Scientific Reports · doi:10.1038/srep26358 · Cited by 34 · see citing works
Tian, H., Gao, Z., Wang, G., Li, H., & Zheng, J. (2015) · Tumor Biology · doi:10.1007/s13277-015-4370-6 · Cited by 34 · see citing works
D’Amico, R., Cordaro, M., Fusco, R., Peritore, A. F., Genovese, T., Gugliandolo, E., Crupi, R., Mandalari, G., Caccamo, D., Cuzzocrea, S., et al. (2022) · Nutrients · doi:10.3390/nu14071474 · Cited by 29 · see citing works
Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy
Henpita, C., Vyas, R., Healy, C. L., Kieu, T. L., Gurkar, A. U., Yousefzadeh, M. J., Cui, Y., Lu, A., Angelini, L. A., O'Kelly, R. D., et al. (2023) · Aging Cell · doi:10.1111/acel.13782 · Cited by 28 · see citing works
Li, W., Li, Z., Zhou, D., Zhang, X., Yan, J., & Huang, G. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2018.11.002 · Cited by 26 · see citing works
Moyano, P., Garcia, J., García, J., Anadon, M., Naval, M., Frejo, M., Sola, E., Pelayo, A., & del Pino, J. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110975 · Cited by 22 · see citing works
Yu, Y., Wei, S., Weiss, R. M., & Felder, R. B. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00499.2018 · Cited by 24 · see citing works
Sobočanec, S., Šarić, A., Šafranko, Ž. M., Hadžija, M. P., Abramić, M., & Balog, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.014 · Cited by 23 · see citing works
Tseng, Y., Tsai, Y., Fülöp, F., Chang, F., & Lo, Y. (2019) · Molecules · doi:10.3390/molecules24122249 · Cited by 22 · see citing works
Homocysteine downregulates gene expression of heme oxygenase-1 in hepatocytes
Luo, X., Xiao, L., Yang, H., Zhang, R., Jiang, M., Ni, J., Lei, T., & Wang, N. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-55 · Cited by 20 · see citing works
Song, S., Wu, S., Wang, Y., Wang, Z. P., Ye, C.-X., Song, R., Song, D., & Ruan, Y. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.10.021 · Cited by 18 · see citing works
Pharmacokinetics and Biological Activities of Notoginsenoside R1: A Systematical Review
Wen, C., Liao, X., Ye, X., & Lai, W. (2025) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x25500090 · Cited by 17 · see citing works
Darawsha, A., Trachtenberg, A., & Sharoni, Y. (2024) · Antioxidants · doi:10.3390/antiox13081019 · Cited by 18 · see citing works
Fernandez, V. S., Cipolletti, M., Ascenzi, P., Marino, M., & Fiocchetti, M. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7870 · Cited by 17 · see citing works
Zhang, M., Wang, D., & Li, B. (2019) · Natural Product Research · doi:10.1080/14786419.2019.1636241 · Cited by 15 · see citing works
Moyano, P. M., Sanjuan, J., García, J. M., Anadón, M. J., Lobo, M., Pelayo, A., García, J., Frejo, M. T., & del Pino, J. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110961 · Cited by 16 · see citing works
Shintaro Hojyo, T. M. (2014) · Receptors & Clinical Investigation · doi:10.14800/rci.316 · Cited by 14 · see citing works
Mirzamohammadi, S., Mehrabani, M., Maroof, N. T., & Sharifi, A. M. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327115586208 · Cited by 13 · see citing works
Liu, K., Tao, X., Su, J., Li, F., Mu, F., Zhao, S., Lu, X., Li, J., Chen, S., Dong, T., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255736 · Cited by 11 · see citing works
Nasuti, C., Carloni, M., Fedeli, D., Stefano, A. D., Marinelli, L., Cerasa, L. S., Meda, C., Maggi, A. C., & Gabbianelli, R. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.05.035 · Cited by 10 · see citing works
Kubo, Y., Gonzalez, J. A. H., Beckmann, R., Weiler, M., Pahlavani, H., Saldívar, M. C., Szymanski, K., Rosenhain, S., Fragoulis, A., Leeflang, M. A., et al. (2022) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-022-05942-1 · Cited by 9 · see citing works
Decoding the NRF2–NOTCH Crosstalk in Lung Cancer—An Update
Sparaneo, A., Torrisi, F., D’Angeli, F., Giurdanella, G., Bravaccini, S., Muscarella, L. A., & Fabrizio, F. P. (2025) · Antioxidants · doi:10.3390/antiox14060657 · Cited by 7 · see citing works
Lei, X., Yang, Q., Wei, Y.-Z., Qiu, X., Zeng, H.-Y., Yan, A.-M., Peng, K., Li, Y., Rao, F.-Q., Chen, F., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e23002 · Cited by 7 · see citing works
Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women with Gynecologic Cancer
Narumi, M., Takahashi, K., Yamatani, H., Seino, M., Yamanouchi, K., Ohta, T., Takahashi, T., Kurachi, H., & Nagase, S. (2017) · Journal of Women s Health · doi:10.1089/jwh.2016.6301 · Cited by 7 · see citing works
Promoting Resiliency to Stress in the Vascular Endothelium
Jaramillo-Torres, M. J., Limpert, R., Butak, W., Cohen, K. E., Whitaker, A. A., SenthilKumar, G., Durand, M. J., & Freed, J. K. (2025) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.70001 · Cited by 5 · see citing works
Sex Difference of Colorectal Cancer
Kim, N. (2022) · Springer eBooks · doi:10.1007/978-981-19-0120-1_20 · Cited by 4 · see citing works
Thorley, J., Alhebshi, A., Bailey, S. J., Martin, N. R. W., BISHOP, N. C., & Clifford, T. (2024) · Redox Experimental Medicine · doi:10.1530/rem-24-0003 · Cited by 3 · see citing works
Estrogen differentially regulates expression of P-38 and hemeoxygenase-1 in mouse cervix
Shah, R. (2014) · Chronicle of The New Researcher · doi:10.1511/ctnr.2014.1 · Cited by 2 · see citing works
Colorectal Diseases and Gut Microbiome
Kim, N. (2024) · Springer eBooks · doi:10.1007/978-981-97-0130-8_6 · Cited by 1 · see citing works
Chen, J., Zhao, R., Yangwei, W., Xiao, H., Lin, W., Diao, M., He, S., Mei, P., & Liao, Y. (2024) · Figshare · doi:10.6084/m9.figshare.26683840
- Authors
- Chen, C.-S., Tseng, Y.-T., Hsu, Y.-Y., & Lo, Y.-C.
- Affiliations
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
- Venue
- Neuroendocrinology
- Publisher
- S. Karger AG
- Published
- 2012-11-02
- Volume
- 97
- Issue
- 3
- Pages
- 232-241
- ISSN
- 0028-3835 (ISSN-L)
- 1423-0194
- OpenAlex
- W2033037571
- Cited by
- 50
- References
- 39
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 8 · 2013: 1
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kaohsiung Medical University
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Nrf2/Keap1 pathway, estradiol, neuroprotection, antioxidant defense, cell survival signaling, Akt signaling, glycogen synthase kinase-3β, heme oxygenase-1, superoxide dismutase, reactive oxygen species, apoptosis, estrogen receptor, PI3K signaling, caspase activation, Bcl-2
- MeSH terms
- Glycogen Synthase Kinase 3 beta, Kelch-Like ECH-Associated Protein 1, Fulvestrant, Antioxidants, Cell Survival, Chromones, Estradiol, Estrogen Antagonists, Homocysteine, Humans, Morpholines, Superoxide Dismutase, Signal Transduction, Up-Regulation, Apoptosis, Reactive Oxygen Species, Proto-Oncogene Proteins c-bcl-2, Glycogen Synthase Kinase 3, Cytochromes c, Cell Line, Tumor, Protein Kinase Inhibitors, Intracellular Signaling Peptides and Proteins, NF-E2-Related Factor 2, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review