17β-estradiol up-regulates Nrf2 Via Pi3k/Akt and estrogen receptor signaling pathways to suppress light-induced degeneration in rat retina

AKT/PKB signaling: navigating downstream

Manning, B. D., & Cantley, L. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.009 · Cited by 6,115 · see citing works

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630 · see citing works

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378 · see citing works

Mechanisms of estrogen action.

Nilsson, S., Mäkelä, S., Treuter, E., Tujague, M., Thomsen, J., Andersson, G., Enmark, E., Pettersson, K., Warner, M., & Gustafsson, J.-Å. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1535 · Cited by 2,059 · see citing works

Estrogen receptors: how do they signal and what are their targets

Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Ström, A., Treuter, E., Warner, M., et al. (2007) · Physiological Reviews · doi:10.1152/physrev.00026.2006 · Cited by 1,857 · see citing works

Estrogen Signaling Multiple Pathways to Impact Gene Transcription

Marino, M., Galluzzo, P., & Ascenzi, P. (2006) · Current Genomics · doi:10.2174/138920206779315737 · Cited by 618 · see citing works

Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways

Safe, S., & Kim, K. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0103 · Cited by 368 · see citing works

Reflections on the Discovery and Significance of Estrogen Receptor β

Koehler, K. F., Helguero, L. A., Haldosén, L.-A., Warner, M., & Gustafsson, J.-A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0027 · Cited by 360 · see citing works

Essential Roles of the PI3 Kinase/Akt Pathway in Regulating Nrf2-Dependent Antioxidant Functions in the RPE

Wang, L., Chen, Y., Sternberg, P., & Cai, J. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1099 · Cited by 267 · see citing works

Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

Lewis, K. N., Mele, J., Hayes, J. D., & Buffenstein, R. (2010) · Integrative and Comparative Biology · doi:10.1093/icb/icq034 · Cited by 247 · see citing works

Curcumin protects retinal cells from light-and oxidant stress-induced cell death

Mandal, M. N. A., Patlolla, J. M. R., Zheng, L., Agbaga, M., Tran, J.-T. A., Wicker, L. D., Kasus‐Jacobi, A., Elliott, M. H., Rao, C. V., & Anderson, R. E. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.006 · Cited by 218 · see citing works

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

Tanito, M., Masutani, H., Kim, Y., Nishikawa, M., Ohira, A., & Yodoi, J. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1120 · Cited by 192 · see citing works

Serum and glucocorticoid‐regulated protein kinases: Variations on a theme

Tessier, M., & Woodgett, J. R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20894 · Cited by 175 · see citing works

Increased Glutathione Synthesis through an ARE-Nrf2–Dependent Pathway by Zinc in the RPE: Implication for Protection against Oxidative Stress

Ha, K.-N., Chen, Y., Cai, J., & Sternberg, P. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1322 · Cited by 155 · see citing works

Astaxanthin protects ARPE-19 cells from oxidative stress via upregulation of Nrf2-regulated phase II enzymes through activation of PI3K/Akt.

Li, Z., Dong, X. Y., Liu, H., et al. (2013) · PubMed · Cited by 133 · see citing works

Active oxygen chemistry within the liposomal bilayer

Afri, M., Frimer, A. A., & Cohen, Y. (2004) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2004.04.006 · Cited by 132 · see citing works

Protective effect of lipoic acid against oxidative stress is mediated by Keap1/Nrf2-dependent heme oxygenase-1 induction in the RGC-5 cellline

Koriyama, Y., Nakayama, Y., Matsugo, S., & Kato, S. (2013) · Brain Research · doi:10.1016/j.brainres.2012.12.041 · Cited by 112 · see citing works

Inflammation and Age-Related Macular Degeneration (AMD)

Telander, D. G. (2011) · Seminars in Ophthalmology · doi:10.3109/08820538.2011.570849 · Cited by 110 · see citing works

Nuclear Receptors in Bone Physiology and Diseases

Imai, Y., Youn, M., Inoue, K., Takada, I., Kouzmenko, A., & Kato, S. (2013) · Physiological Reviews · doi:10.1152/physrev.00008.2012 · Cited by 89 · see citing works

Mechanisms of Estrogen Receptor Action in the Myocardium

de Jager, T., Pelzer, T., Müller-Botz, S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010984200 · Cited by 87 · see citing works

Synthetic Triterpenoids Attenuate Cytotoxic Retinal Injury: Cross-talk between Nrf2 and PI3K/AKT Signaling through Inhibition of the Lipid Phosphatase PTEN

Pitha, I., Liby, K. T., Royce, D. B., & Sporn, M. B. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3648 · Cited by 83 · see citing works

Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein

Zhang, S. X., Wang, J. J., Dashti, A., Wilson, K., Zou, M., Szweda, L. I., Ma, J., & Lyons, T. J. (2008) · Journal of Molecular Endocrinology · doi:10.1677/jme-08-0011 · Cited by 74 · see citing works

Nutrient Supplementation with n3 Polyunsaturated Fatty Acids, Lutein, and Zeaxanthin Decrease A2E Accumulation and VEGF Expression in the Retinas of Ccl2/Cx3cr1-Deficient Mice on Crb1 Background1–3

Ramkumar, H. L., Tuo, J., Shen, D. F., Zhang, J., Cao, X., Chew, E. Y., & Chan, C. (2013) · Journal of Nutrition · doi:10.3945/jn.112.169649 · Cited by 73 · see citing works

Estrogen and the female heart

Knowlton, A. A., & Korzick, D. H. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.002 · Cited by 72 · see citing works

Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis

Yao, J., Bi, H.-E., Sheng, Y., Cheng, L., Wendu, R.-L., Wang, C., Cao, G.-F., & Jiang, Q. L. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140510355 · Cited by 71 · see citing works

Effects of Hormone Therapy on Depressive Symptoms and Cognitive Functions in Women With Alzheimer Disease: A 12 Month Randomized, Double-Blind, Placebo-Controlled Study of Low-Dose Estradiol and Norethisterone

Valen-Sendstad, A., Engedal, K., Stray‐Pedersen, B., Strobel, C., Barnett, L., Nurminemi, M., & Meyer, N. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181beaaf4 · Cited by 61 · see citing works

17-β Estradiol Protects ARPE-19 Cells from Oxidative Stress through Estrogen Receptor-β

Giddabasappa, A., Bauler, M. N., Yepuru, M., Chaum, E., Dalton, J. T., & Eswaraka, J. R. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5316 · Cited by 54 · see citing works

Fluorophotometric quantitation of oxidative stress in the retina in vivo.

Takanashi, T., Ogura, Y., Taguchi, H., et al. (1997) · PubMed · Cited by 53 · see citing works

Nrf2-Keap1 antioxidant defense and cell survival signaling are upregulated by 17β-estradiol in homocysteine-treated dopaminergic sh-Sy5y cells

Chen, C.-S., Tseng, Y.-T., Hsu, Y.-Y., & Lo, Y.-C. (2013) · Neuroendocrinology · doi:10.1159/000342692 · Cited by 50 · see citing works

PI3K/Akt and NF-κB activation following intravitreal administration of 17β-estradiol: Neuroprotection of the rat retina from light-induced apoptosis

Mo, M., Li, H.-B., Wang, B.-Y., Wang, S.-L., Zhu, Z., & Yu, X. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.002 · Cited by 49 · see citing works

Advances in the genomics of common eye diseases

Bailey, J. N. C., Sobrin, L., Pericak‐Vance, M. A., Haines, J. L., Hammond, C. J., & Wiggs, J. L. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt396 · Cited by 49 · see citing works

17β‐Estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation

Yu, J., Zhao, Y., Li, B., Sun, L., & Huo, H. (2012) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21417 · Cited by 46 · see citing works

Cytotoxic Effects of Curcumin in Human Retinal Pigment Epithelial Cells

Hollborn, M., Chen, R., Wiedemann, P., Reichenbach, A., Bringmann, A., & Kohen, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059603 · Cited by 41 · see citing works

17β-Estradiol Ameliorates Light-Induced Retinal Damage in Sprague–Dawley Rats by Reducing Oxidative Stress

Wang, S., Wang, B., Feng, Y., et al. (2014) · Journal of Molecular Neuroscience · doi:10.1007/s12031-014-0384-6 · Cited by 40 · see citing works

Nrf2-dependent and Nrf2-independent induction of phase 2 detoxifying and antioxidant enzymes during keratinocyte differentiation

Piao, M. S., Park, J.-J., Choi, J.-Y. J., Lee, D., Yun, S. J., Lee, J.-B., & Lee, S. (2012) · Archives of Dermatological Research · doi:10.1007/s00403-012-1215-7 · Cited by 39 · see citing works

Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels.

Tsuruma, K., Tanaka, Y., Shimazawa, M., Mashima, Y., & Hara, H. (2011) · Europe PMC (PubMed Central) · Cited by 36 · see citing works

Phosphatidylinositol 3 Kinase Pathway and 4-Hydroxy-2-Nonenal-Induced Oxidative Injury in the RPE

Chen, J., Wang, L., Chen, Y., Sternberg, P., & Cai, J. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2439 · Cited by 35 · see citing works

Light exposure causes functional changes in the retina: increased photoreceptor cation channel permeability, photoreceptor apoptosis, and altered retinal metabolic function

Yu, T., Acosta, M. L., Ready, S., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04766.x · Cited by 30 · see citing works

Efficacy of various antioxidants in the protection of the retinal pigment epithelium from oxidative stress

Hutnik, C. M. L., Kagan, D. B., & Liu, H. (2012) · Clinical ophthalmology · doi:10.2147/opth.s35139 · Cited by 28 · see citing works

17β-Estradiol protects lymphocytes against dopamine and iron-induced apoptosis by a genomic-independent mechanism

Jiménez-Del-Río, M., & Velez‐Pardo, C. (2000) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(01)00082-9 · Cited by 27 · see citing works

The Antioxidant Role of a Reagent, 2′,7′-Dichlorodihydrofluorescin Diacetate, Detecting Reactive-Oxygen Species and Blocking the Induction of Heme Oxygenase-1 and Preventing Cytotoxicity

Andoh, Y., Mizutani, A., Ohashi, T., Kojo, S., Ishii, T., Adachi, Y., Ikehara, S., & Taketani, S. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj187 · Cited by 25 · see citing works

Dynamic, in vivo, real-time detection of retinal oxidative status in a model of elevated intraocular pressure using a novel, reversibly responsive, profluorescent nitroxide probe

Rayner, C. L., Gole, G. A., Bottle, S. E., & Barnett, N. L. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.10.013 · Cited by 23 · see citing works

The Involvement of PI3K-Mediated and L-VGCC-Gated Transient Ca2+ Influx in 17β-Estradiol-Mediated Protection of Retinal Cells from H2O2-Induced Apoptosis with Ca2+ Overload

Feng, Y., Wang, B., Du, F., Li, H., Wang, S., Hu, C., Zhu, C., & Yu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077218 · Cited by 22 · see citing works

17β-Estradiol Impedes Bax-Involved Mitochondrial Apoptosis of Retinal Nerve Cells Induced by Oxidative Damage via the Phosphatidylinositol 3-Kinase/Akt Signal Pathway

Li, H., Wang, B., Zhu, C., et al. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-9968-9 · Cited by 19 · see citing works

Effect of estrogen and ovariectomy on response of the female rabbit urinary bladder to two forms of in vitro oxidative stress

Malone, L., Schuler, C., Leggett, R. E., & Levin, R. M. (2013) · International Urogynecology Journal · doi:10.1007/s00192-013-2289-2 · Cited by 18 · see citing works

Hippocampal Nerve Growth Factor Potentiated by 17β-Estradiol and Involved in Allodynia of Inflamed TMJ in Rat

Wu, Y., Kou, X., Bi, R.-Y., Xu, W., Wang, K., Gan, Y.-H., & Ma, X. (2012) · Journal of Pain · doi:10.1016/j.jpain.2012.03.005 · Cited by 16 · see citing works

17β-Estradiol Protects 7-Day Old Rats From Acute Brain Injury and Reduces the Number of Apoptotic Cells

Müller, M. M., Middelanis, J., Meier, C., et al. (2012) · Reproductive Sciences · doi:10.1177/1933719112452471 · Cited by 15 · see citing works

Neuroprotective strategies for retinal disease

Pardue, M. T., & Allen, R. S. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.02.002 · Cited by 237 · see citing works

From mitochondria to sarcopenia: role of 17β-estradiol and testosterone

Tian, X., Lou, S., & Shi, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1156583 · Cited by 54 · see citing works

17β-estradiol plays the anti-osteoporosis role via a novel ESR1-Keap1-Nrf2 axis-mediated stress response activation and Tmem119 upregulation

Yang, R., Li, J., Zhang, J., Xue, Q., Qin, R., Wang, R., Goltzman, D., & Miao, D. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.102 · Cited by 48 · see citing works

Paternal retrieval behavior regulated by brain estrogen synthetase (aromatase) in mouse sires that engage in communicative interactions with pairmates

Akther, S., Huang, Z., Liang, M., Zhong, J., Fakhrul, A. A. K. M., Yuhi, T., Lopatina, O., Salmina, A. B., Yokoyama, S., Higashida, C., et al. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00450 · Cited by 38 · see citing works

Solanine Interferes with AKT/p-AKT and PI3K/p-PI3K Pathway to Inhibit HIF and Destroy Cell Energy Metabolism

Wang, Y., Wang, P., & Zhao, W. (2021) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2021.910008 · Cited by 1 · see citing works

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

Lin, A., Piao, H.-L., Li, Z., Sarbassov, D. D., Ma, L., & Gan, B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1729 · Cited by 148 · see citing works

Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects

Dufour, M., Dormond-Meuwly, A., Pythoud, C., Demartines, N., & Dormond, O. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.014 · Cited by 21 · see citing works

Virtual Docking Screening and QSAR Studies to Explore PI3K and mTOR Inhibitors Acting on AKT in Cancers

Kandoussi, I., Benherrif, O., Lakhlili, W., et al. (2020) · Journal of Cancer Science and Clinical Therapeutics · doi:10.26502/jcsct.5079099 · Cited by 1 · see citing works

Solanine Interferes With AKT/p-AKT and PI3K/ p-PI3K to Inhibit HIF and Destroy Cell Energy MetabolismPreprint

Wang, P., & Wang, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-663150/v1