The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Dental Caries from a Molecular Microbiological Perspective
Open accessAbstract
Dental caries results from an imbalance of the metabolic activity in the dental biofilm. The microbial communities of teeth have traditionally been studied by standard cultural approaches. More recently, cloning and sequencing of the 16S rRNA gene have been used to characterize the microbial composition of the oral biofilm, but the methodological limitations of this approach have now been recognized. Next-generation high-throughput sequencing methods have the potential to reveal the composition and functioning of the biofilm by means of metagenomic and metatranscriptomic analyses. Currently available high-throughput sequencing approaches are reviewed and discussed in relation to studying the biofilm associated with dental caries. Important in understanding the dynamic processes in caries is the metabolic activity of the biofilm; metabolome analysis is a new tool that might enable us to assess such activity. As caries is a localized disease, it is essential that biofilm samples are taken from precisely determined tooth sites; pooling samples is not appropriate. This paper presents the case that culture-based studies are important, but that the fullest understanding of the role of the biofilm in the caries process will only come from an integrated approach determining biological function and metabolic output.
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Cites
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Sequencing technologies – the next generation
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Self-citationOrganised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
Touchon, M., Hoede, C., Tenaillon, O., Barbe, V., Baeriswyl, S., Bidet, P., Bingen, E., Bonacorsi, S., Bouchier, C., Bouvet, O., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000344 · Cited by 1,181
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Cited by
Falsetta, M. L., Klein, M. I., Colonne, P. M., Scott-Anne, K., Gregoire, S., Pai, C.-H., Gonzalez-Begne, M., Watson, G., Krysan, D. J., Bowen, W. H., et al. (2014) · Infection and Immunity · doi:10.1128/iai.00087-14 · Cited by 561
Oral Microbiome Metabolism: From “Who Are They?” to “What Are They Doing?”
Takahashi, N. (2015) · Journal of Dental Research · doi:10.1177/0022034515606045 · Cited by 488
Self-citationThe Oral Microbiome in Dental Caries
STRUŻYCKA, I. (2014) · Polish Journal of Microbiology · doi:10.33073/pjm-2014-018 · Cited by 380
Duncan, H. F., Kirkevang, L., Peters, O. A., El‐Karim, I., Krastl, G., Del Fabbro, M., Chong, B. S., Galler, K. M., Segura‐Egea, J. J., Kebschull, M., et al. (2023) · International Endodontic Journal · doi:10.1111/iej.13974 · Cited by 304
Dzidic, M., Collado, M. C., Abrahamsson, T., Artacho, A., Stensson, M., Jenmalm, M. C., & Mira, A. (2018) · The ISME Journal · doi:10.1038/s41396-018-0204-z · Cited by 279
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Metadata
- Authors
- Nyvad, B., Crielaard, W., Mira, A., Takahashi, N., & Beighton, D.
- Venue
- Caries Research
- Publisher
- S. Karger AG
- Published
- 2012-11-30
- Volume
- 47
- Issue
- 2
- Pages
- 89-102
- ISSN
- 0008-6568 (ISSN-L)
- 1421-976X
- OpenAlex
- W2167187012
- Cited by
- 266
- References
- 108
- FWCI
- 19.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
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