Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay
Open accessAbstract
Information on how the oral microbiome develops during early childhood and how external factors influence this ecological process is scarce. We used high-throughput sequencing to characterize bacterial composition in saliva samples collected at 3, 6, 12, 24 months and 7 years of age in 90 longitudinally followed children, for whom clinical, dietary and health data were collected. Bacterial composition patterns changed through time, starting with “early colonizers”, including Streptococcus and Veillonella; other bacterial genera such as Neisseria settled after 1 or 2 years of age. Dental caries development was associated with diverging microbial composition through time. Streptococcus cristatus appeared to be associated with increased risk of developing tooth decay and its role as potential biomarker of the disease should be studied with species-specific probes. Infants born by C-section had initially skewed bacterial content compared with vaginally delivered infants, but this was recovered with age. Shorter breastfeeding habits and antibiotic treatment during the first 2 years of age were associated with a distinct bacterial composition at later age. The findings presented describe oral microbiota development as an ecological succession where altered colonization pattern during the first year of life may have long-term consequences for child´s oral and systemic health.
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The most frequently detected early colonizers of the predental oral cavity include Streptococcus, Staphylococcus, and Fusobacterium species.
“The most frequently detected early colonizers of the predental oral cavity include Streptococcus, Staphylococcus, and Fusobacterium species.142, 143”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [142]
Additional early colonizers, such as Gemella, Rothia, Granulicatella, and Haemophilus, are present at 3-6 months of age and increase in abundance with time.
“Additional early colonizers, such as Gemella, Rothia, Granulicatella, and Haemophilus, present at 3‐6 months of age and increase in abundance with time.141, 142”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [142]
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- Authors
- Dzidic, M., Collado, M. C., Abrahamsson, T., Artacho, A., Stensson, M., Jenmalm, M. C., & Mira, A.
- Affiliations
- Linköping University (SE)
- Institute of Agrochemistry and Food Technology (IATA-CSIC), Department of Biotechnology, Unit of Lactic Acid Bacteria and Probiotics , Valencia, Spain
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Jönköping University (SE)
- Department of Health and Genomics, Center for Advanced Research in Public Health, CSISP-FISABIO , Valencia, Spain
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2018-06-13
- Volume
- 12
- Issue
- 9
- Pages
- 2292-2306
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- PMC
- PMC6092374
- OpenAlex
- W2808685653
- Cited by
- 279
- References
- 107
- Citations by year
- 2026: 40 · 2025: 25 · 2024: 34 · 2023: 39 · 2022: 38 · 2021: 44 · 2020: 31 · 2019: 27 · 2018: 1
- FWCI
- 29.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The ISME Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Diva portal (Dalarna University Library) (submittedVersion, other-oa)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- Funders
- EC | European Research Council (639226)
- Vetenskapsrådet (2016-01698)
- EC | European Research Council (ERC) (639226)
- Vetenskapsrådet (Swedish Research Council) (2016-01698)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- oral microbiota, early childhood, dental caries, Streptococcus cristatus, Veillonella, Neisseria, breastfeeding, antibiotic exposure, infant colonization
- MeSH terms
- Anti-Bacterial Agents, Bacteria, Breast Feeding, Child, Child, Preschool, Dental Caries, Humans, Infant, Longitudinal Studies, Mouth, Saliva, Streptococcus, Delivery, Obstetric, Ecological and Environmental Phenomena, Microbiota
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