Aging-Related Genes in Mesenchymal Stem Cells: A Mini-Review
Abstract
Adult stem cells in mammalian organs play pivotal roles in the maintenance and repair of these organs throughout the life of the adult and maintain the proper homeostasis of a tissue or organ. Among the adult stem cells described to date, mesenchymal stem cells (MSCs) are highlighted for clinical applications because MSCs have many advantages for cell therapy, including multilineage differentiation, homing, immune modulation and wound-healing effects. However, as the aging of MSCs leads to an age-associated decline in their number and function, it is important to clarify the age-associated factors and regulatory mechanism associated with the MSC aging process. In this review, we amass and discuss the recent data related to age-associated genes in MSCs. In particular, the activities of epigenetic regulatory factors, including histone acetylase and DNA methyltransferase, modulate gene expression and crosstalk with each other during the MSC senescence process. p16 INK4A and high-mobility group A2 play important age-associated roles in the regulation of MSC stemness, and lamin A- and prelamin A-dependent nuclear abnormalities have significant biological relevance in MSC aging. Taken together, the information described here, including the epigenetic regulatory factors, transcription factors and cell signaling, could be used toward the development of treatments for MSC aging and related defects.
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Treatment of rats, mice, and pigs with GHK effectively activates systemic healing throughout the animal.
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Cites
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325 · see citing works
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106 · see citing works
Muraglia, A., Cancedda, R., & Quarto, R. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.7.1161 · Cited by 1,025 · see citing works
Cellular senescence and tumor suppressor gene p16
Rayess, H., Wang, M. B., & Srivatsan, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27316 · Cited by 825 · see citing works
HMG domain proteins: architectural elements in the assembly of nucleoprotein structures
Grosschedl, R., Giese, K., & Pagel, J. M. (1994) · Trends in Genetics · doi:10.1016/0168-9525(94)90232-1 · Cited by 817 · see citing works
Genomic instability in laminopathy-based premature aging
Liu, B., Wang, J., Chan, K. M., Tjia, W. M., Deng, W., Guan, X., Huang, J.-D., Li, K. M., Chau, P. Y., Chen, D. J., et al. (2005) · Nature Medicine · doi:10.1038/nm1266 · Cited by 650 · see citing works
Nishino, J., Kim, I., Chada, K. K., & Morrison, S. J. (2008) · Cell · doi:10.1016/j.cell.2008.09.017 · Cited by 623 · see citing works
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
Scaffidi, P., & Misteli, T. (2008) · Nature Cell Biology · doi:10.1038/ncb1708 · Cited by 500 · see citing works
DNA damage checkpoints in stem cells, ageing and cancer
Sperka, T., Wang, J., & Rudolph, K. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3420 · Cited by 393 · see citing works
Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration
Kode, J., Mukherjee, S., Joglekar, M. V., & Hardikar, A. A. (2009) · Cytotherapy · doi:10.1080/14653240903080367 · Cited by 384 · see citing works
Ragnauth, C. D., Warren, D. T., Liu, Y., McNair, R., Tajsic, T., Figg, N. L., Shroff, R. C., Skepper, J. N., & Shanahan, C. M. (2010) · Circulation · doi:10.1161/circulationaha.109.902056 · Cited by 380 · see citing works
Regulation of histone deacetylase activities
Sengupta, N., & Seto, E. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20179 · Cited by 347 · see citing works
Immunogenicity of allogeneic mesenchymal stem cells
Schu, S., Nosov, M., O’Flynn, L., Shaw, G., Treacy, O., Barry, F., Murphy, M. J., O’Brien, T., & Ritter, T. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01509.x · Cited by 324 · see citing works
Cao, K., Blair, C. D., Faddah, D. A., Kieckhaefer, J. E., Olive, M., Erdos, M. R., Nabel, E. G., & Collins, F. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43578 · Cited by 305 · see citing works
Demethylase Activity Is Directed by Histone Acetylation
Cervoni, N., & Szyf, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103921200 · Cited by 293 · see citing works
Iglesias-Bartolome, R., Patel, V., Cotrim, A., Leelahavanichkul, K., Molinolo, A. A., Mitchell, J. B., & Gutkind, J. S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.06.007 · Cited by 284 · see citing works
Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation
Li, Z., Liu, C., Xie, Z., Song, P., Zhao, R. C. H., Guo, L., Liu, Z., & Wu, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020526 · Cited by 220 · see citing works
Shibata, K. R., Aoyama, T., Shima, Y., Fukiage, K., Otsuka, S., Furu, M., Kohno, Y., Ito, K., Fujibayashi, S., Neo, M., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0225 · Cited by 216 · see citing works
A-type lamins: Guardians of the soma?
Hutchison, C., & Worman, H. J. (2004) · Nature Cell Biology · doi:10.1038/ncb1104-1062 · Cited by 208 · see citing works
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24
Corrigan, D. P., Kuszczak, D., Rusiñol, A. E., Thewke, D. P., Hrycyna, C. A., Michaelis, S., & Sinensky, M. S. (2005) · Biochemical Journal · doi:10.1042/bj20041359 · Cited by 187 · see citing works
DNA Methyltransferase Controls Stem Cell Aging by Regulating BMI1 and EZH2 through MicroRNAs
So, A.-Y., Jung, J., Lee, S., Kim, H., & Kang, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019503 · Cited by 180 · see citing works
Self-citationWare, C. B., Wang, L., Mecham, B. H., Shen, L., Nelson, A. M., Bar, M., Lamba, D. A., Dauphin, D. S., Buckingham, B. P., Askari, B., et al. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.03.001 · Cited by 166 · see citing works
Jung, J., Lee, S., Seo, M., Park, S., Kurtz, A., Kang, S., & Kang, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0242-9 · Cited by 127 · see citing works
Self-citationKarantzali, E., Schulz, H., Hummel, O., Hübner, N., Hatzopoulos, A., & Kretsovali, A. (2008) · Genome biology · doi:10.1186/gb-2008-9-4-r65 · Cited by 105 · see citing works
Lee, S., Jung, J.-W., Park, S., Roh, K.-H., Lee, S. Y., Kim, J. H., Kang, S.-K., & Kang, K. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0457-9 · Cited by 101 · see citing works
Self-citationGu, Z., Cao, X., Jiang, J., Li, L., Da, Z., Liu, H. S., & Cheng, C. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.07.012 · Cited by 74 · see citing works
Yu, K., Park, S., Jung, J., Seo, M., Hong, I., Kim, H., Seo, Y., Kang, T., Lee, J. Y., Kurtz, A., et al. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.11.002 · Cited by 65 · see citing works
Self-citationMesenchymal stem cells express serine protease inhibitor to evade the host immune response
Haddad, N. E., Heathcote, D. A., Moore, R. F., Yang, S., Azzi, J. R., Mfarrej, B. G., Atkinson, M. A., Sayegh, M. H., Lee, J.-S., Ashton‐Rickardt, P. G., et al. (2010) · Blood · doi:10.1182/blood-2010-06-287979 · Cited by 46 · see citing works
Zheng, Y., He, L., Wan, Y., & Song, J. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0172 · Cited by 43 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges
Bagno, L., Hatzistergos, K. E., Balkan, W., & Hare, J. M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.009 · Cited by 342 · see citing works
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
Pan, H., Guan, D., Liu, X., Li, J., Wang, L., Wu, J., Zhou, J., Zhang, W., Ren, R., Zhang, W., et al. (2016) · Cell Research · doi:10.1038/cr.2016.4 · Cited by 334 · see citing works
Costa, L. A., Eiró, N., Fraile, M., González, L. O., Saá, J., García-Portabella, P., Vega, B., Schneider, J., & Vizoso, F. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03600-0 · Cited by 317 · see citing works
Senescence of mesenchymal stem cells (Review)
Li, Y., Wu, Q., Wang, Y., Li, L., Bu, H., & Bao, J. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2912 · Cited by 275 · see citing works
Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives
Lee, W., & Wang, B. (2017) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2017.03.005 · Cited by 209 · see citing works
Zuo, R., Liu, M.-H., Wang, Y.-Q., Li, J., Wang, W., Wu, J.-L., Sun, C., Li, B., Wang, Z., Lan, W.-R., et al. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-018-1121-9 · Cited by 173 · see citing works
Miceli, V., Bulati, M., Iannolo, G., Zito, G., Gallo, A., & Conaldi, P. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020763 · Cited by 176 · see citing works
Salminen, A., Kauppinen, A., Hiltunen, M. O., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.05.004 · Cited by 142 · see citing works
Age-related cerebral small vessel disease and inflammaging
Li, T., Huang, Y., Cai, W., Chen, X., Men, X., Lü, T., Wu, A., & Lu, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03137-x · Cited by 127 · see citing works
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics
Zhu, Y., Ge, J., Huang, C., Liu, H., & Jiang, H. (2021) · Theranostics · doi:10.7150/thno.46436 · Cited by 125 · see citing works
Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging
Neri, S., & Borzı̀, R. M. (2020) · Biomolecules · doi:10.3390/biom10020340 · Cited by 122 · see citing works
Vizoso, F. J., Eiró, N., Costa, L. A., Esparza, P., Landín, M., Díaz‐Rodríguez, P., Schneider, J., & Pérez-Fernández, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153738 · Cited by 106 · see citing works
Kim, J., Piao, Y., Pak, Y. K., Chung, D.-H., Han, Y. M., Hong, J. S., Jun, E. J., Shim, J., Choi, J., & Kim, C. J. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0349 · Cited by 102 · see citing works
Wacleche, V. S., Goulet, J.-P., Gosselin, A., Monteiro, P., Soudeyns, H., Fromentin, R., Jenabian, M.-A., Vartanian, S. M., Deeks, S. G., Chomont, N., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0293-6 · Cited by 98 · see citing works
Mesenchymal stem cell aging: Mechanisms and influences on skeletal and non-skeletal tissues
Liu, H., Xia, X., & Li, B. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215591828 · Cited by 88 · see citing works
Curcumin Affects Adipose Tissue-Derived Mesenchymal Stem Cell Aging Through TERT Gene Expression
Pirmoradi, S., Fathi, E., Farahzadi, R., Pilehvar‐Soltanahmadi, Y., & Zarghami, N. (2017) · Drug Research · doi:10.1055/s-0043-119635 · Cited by 86 · see citing works
Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells
Legzdina, D., Romanauska, A., Nikulshin, S., Kozlovska, T., & Bērziņš, U. (2016) · International Journal of Stem Cells · doi:10.15283/ijsc.2016.9.1.124 · Cited by 80 · see citing works
Zhang, D., Yan, B., Yu, S., Zhang, C., Wang, B., Wang, Y., Wang, J., Yuan, Z., Zhang, L., & Pan, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/867293 · Cited by 75 · see citing works
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01744-1 · Cited by 76 · see citing works
Kim, D. S., Ko, Y. J., Lee, M. W., Park, H. J., Park, Y. J., Kim, D.-I., Sung, K. W., Koo, H. H., & Yoo, K. H. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0733-1 · Cited by 75 · see citing works
Impact of Mesenchymal Stem Cell Senescence on Inflammaging
Lee, B.-C., & Yu, K. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.2.291 · Cited by 70 · see citing works
Self-citationThe Impact of Epigenetics on Mesenchymal Stem Cell Biology
Özkul, Y., & Galderisi, U. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25371 · Cited by 69 · see citing works
Yu, K., Lee, J. Y., Kim, H., Hong, I., Choi, S. W., Seo, Y., Kang, I., Kim, J.-J., Lee, B., Lee, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102426 · Cited by 67 · see citing works
Self-citationMesenchymal Stem Cell Therapy for Aging Frailty
Schulman, I. H., Balkan, W., & Hare, J. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00108 · Cited by 64 · see citing works
Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling
Yang, M., Teng, S., Ma, C., Yu, Y., Wang, P., & Yi, C. (2018) · Cytotechnology · doi:10.1007/s10616-018-0220-x · Cited by 64 · see citing works
miR-543 and miR-590-3p regulate human mesenchymal stem cell aging via direct targeting of AIMP3/p18
Lee, S., Yu, K., Ryu, Y.-S., Oh, Y. S., Hong, I., Kim, H.-S., Lee, J. Y., Kim, S., Seo, K., & Kang, K. (2014) · AGE · doi:10.1007/s11357-014-9724-2 · Cited by 58 · see citing works
Self-citationHuang, B., Wang, B., Lee, W., Kin Pong, U., Leung, K. T., Li, X., Liu, Z., Chen, R., Lin, J., Tsang, L. L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.041 · Cited by 54 · see citing works
Farahzadi, R., Fathi, E., Mesbah‐Namin, S. A., & Zarghami, N. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188052 · Cited by 52 · see citing works
RetractedAge-associated hydroxymethylation in human bone-marrow mesenchymal stem cells
Toraño, E. G., Bayón, G. F., del Real, Á., Sierra, M., García, M. G., Carella, A., Belmonte, T., Urdinguio, R. G., Cubillo, I., Garcı́a-Castro, J., et al. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0966-x · Cited by 49 · see citing works
Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion
Truong, N. C., Bui, K. H.-T., & Pham, P. V. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_235 · Cited by 49 · see citing works
Research progress on sirtuins family members and cell senescence
Wang, T., Wang, Y., Liu, L., Jiang, Z., Li, X., Tong, R., He, J., & Shi, J. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112207 · Cited by 48 · see citing works
Farahzadi, R., Fathi, E., Mesbah‐Namin, S. A., & Zarghami, N. (2018) · Tissue and Cell · doi:10.1016/j.tice.2018.08.012 · Cited by 46 · see citing works
Zheng, W., Wang, X., Li, Y., Qin, J., Zhou, T., Li, D., Xu, Y., Cheng, X., Xiong, Y., & Chen, Z. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00389-7 · Cited by 45 · see citing works
Han, N., Zhang, W., Fang, X., Li, Q.-C., & Pi, W. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.343889 · Cited by 45 · see citing works
Domev, H., Milkov, I., Itskovitz‐Eldor, J., & Dar, A. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0097 · Cited by 43 · see citing works
Molecular mechanisms in cognitive frailty: potential therapeutic targets for oxygen-ozone treatment
Scassellati, C., Ciani, M., Galoforo, A. C., Zanardini, R., Bonvicini, C., & Geroldi, C. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111210 · Cited by 43 · see citing works
GHK and DNA: Resetting the human genome to health
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39 · see citing works
Zhai, W., Yong, D., El‐Jawhari, J. J., CUTHBERT, R., McGonagle, D., Naing, M. W., & Jones, E. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.05.001 · Cited by 39 · see citing works
L-carnitine significantly decreased aging of rat adipose tissue-derived mesenchymal stem cells
Mobarak, H., Fathi, E., Farahzadi, R., Zarghami, N., & Javanmardi, S. (2016) · Veterinary Research Communications · doi:10.1007/s11259-016-9670-9 · Cited by 38 · see citing works
Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss
Zhang, L., Qi, M., Chen, J., Zhao, J., Li, L., Hu, J.-C. E., Jin, Y. J., & Liu, W. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01785-6 · Cited by 38 · see citing works
Fu, H., Chuang, I., Yang, Y.-C., Chuang, P.-C., Lin, H., Ou, Y., Chien, C.-C. C., Huang, H., & Kang, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092541 · Cited by 35 · see citing works
Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors
Rossi, F., Paola, A. D., Pota, E., Argenziano, M., Pinto, D., Marrapodi, M. M., Leva, C. D., Martino, M. D., & Tortora, C. (2021) · Cancers · doi:10.3390/cancers13194933 · Cited by 34 · see citing works
p53 and its mutants on the slippery road from stemness to carcinogenesis
Molchadsky, A., & Rotter, V. (2017) · Carcinogenesis · doi:10.1093/carcin/bgw092 · Cited by 30 · see citing works
de Witte, S. F. H., Peters, F. S., Merino, A. M., Korevaar, S. S., van Meurs, J. B. J., O’Flynn, L., Elliman, S. J., Newsome, P. N., Boer, K., Baan, C. C., et al. (2018) · Cytotherapy · doi:10.1016/j.jcyt.2018.05.005 · Cited by 29 · see citing works
Park, A., Barrera‐Ramirez, J., Ranasinghe, I., Pilon, S., Sy, R. G., Fergusson, D. A., & Allan, D. (2016) · Stem Cell Reviews and Reports · doi:10.1007/s12015-016-9647-7 · Cited by 28 · see citing works
Kostyuk, S. V., Смирнова, Т. А., Kameneva, L. V., Porokhovnik, L. N., Speranskij, A., Ershova, E. S., Stukalov, S., Izhevskaya, V. L., & Veiko, N. N. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/782123 · Cited by 28 · see citing works
Aged mesenchymal stem cells and inflammation: from pathology to potential therapeutic strategies
Yang, X. F., Wang, Y., Rovella, V., Candi, E., Jia, W. P., Bernassola, F., Bove, P., Piacentini, M., Scimeca, M., Sica, G. S., et al. (2023) · Biology Direct · doi:10.1186/s13062-023-00394-6 · Cited by 27 · see citing works
“Ins” and “Outs” of mesenchymal stem cell osteogenesis in regenerative medicine
Yamaguchi, D. T. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.94 · Cited by 27 · see citing works
Kang, J. Y., Oh, M., Joo, H., Park, H. S., Chae, D., Kim, J., Lee, H., Oh, I., & Yu, K. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092913 · Cited by 27 · see citing works
Self-citationMoslem, M., Eberle, I., Weber, I., Henschler, R., & Cantz, T. (2015) · Stem Cells International · doi:10.1155/2015/843058 · Cited by 25 · see citing works
Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
Bellotti, C., Capanni, C., Lattanzi, G., Donati, D. M., Lucarelli, E., & Duchi, S. (2016) · SpringerPlus · doi:10.1186/s40064-016-3091-7 · Cited by 25 · see citing works
Mesenchymal Stem Cell Senescence and Osteogenesis
Tjempakasari, A., Suroto, H., & Santoso, D. (2021) · Medicina · doi:10.3390/medicina58010061 · Cited by 24 · see citing works
Cell culture density affects the proliferation activity of human adipose tissue stem cells
Kim, D. S., Lee, M. W., Ko, Y. J., Chun, Y. H., Kim, H. J., Sung, K. W., Koo, H. H., & Yoo, K. H. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3158 · Cited by 23 · see citing works
Wang, D., Liu, N., Xie, Y., Song, B., Kong, S., & Sun, X. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15081 · Cited by 22 · see citing works
Armbruster, N. S., Krieg, J., Weißenberger, M., Scheller, C., & Steinert, A. F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00255 · Cited by 21 · see citing works
Heart Failure and Adipose Mesenchymal Stem Cells
Matsushita, K. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.003 · Cited by 21 · see citing works
Mazzotti, E., Teti, G., Falconi, M., Chiarini, F., Barboni, B., Mazzotti, A., & Muttini, A. (2019) · Cells · doi:10.3390/cells8101116 · Cited by 20 · see citing works
Rasouli, M., Naeimzadeh, Y., Hashemi, N., & Hosseinzadeh, S. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230113144016 · Cited by 19 · see citing works
Understanding lamin proteins and their roles in aging and cardiovascular diseases
Jiang, Y., & Ji, J. Y. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.09.026 · Cited by 18 · see citing works
Alrefaei, G. I., Ayuob, N. N., Ali, S. S., & Alkarim, S. (2015) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.a2015.0022 · Cited by 18 · see citing works
Lazzarini, R., Caffarini, M., Tang, H., Cerqueni, G., Pellegrino, P., Monsurrò, V., Primio, R. D., & Orciani, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.02.014 · Cited by 14 · see citing works
Roles of Microenvironment on Mesenchymal Stem Cells Therapy for Osteoarthritis
Zhang, H., Jin, C., Hua, J., Chen, Z., Gao, W., Xu, W., Zhou, L., & Shan, L. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s475617 · Cited by 13 · see citing works
Park, H. S., Oh, M., Lee, J. W., Chae, D., Joo, H., Kang, J. Y., An, H. B., Yu, A., Park, J. H., Yoo, H. M., et al. (2021) · International Journal of Stem Cells · doi:10.15283/ijsc21178 · Cited by 13 · see citing works
Self-citationBall, H. C., Moussa, F. M., Mbimba, T., Orman, R., Safadi, F. F., & Cooper, L. N. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.05.009 · Cited by 14 · see citing works
Baek, S. J., Hammock, B. D., Hwang, I. K., Li, Q. X., Moustaïd‐Moussa, N., Park, Y., Safe, S. H., Suh, N., Yi, S.-S., Zeldin, D. C., et al. (2021) · Nutrients · doi:10.3390/nu13061881 · Cited by 13 · see citing works
Maternal and neonatal factors’ effects on wharton's jelly mesenchymal stem cell yield
Mahmoud, R., Bassiouny, M. R., Badawy, A., Darwish, A., Yahia, S., & El-Tantawy, N. L. (2024) · Scientific Reports · doi:10.1038/s41598-024-72386-z · Cited by 12 · see citing works
Li, M., Guo, K., Adachi, Y., & Ikehara, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020183 · Cited by 12 · see citing works
The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells
Jeong, Y.-H., Oh, H., Lee, M. R., Kim, C., Joo, C., Park, S., Song, Y.-H., Kang, C., Chung, H., Kang, S., et al. (2018) · Polymers · doi:10.3390/polym10080839 · Cited by 12 · see citing works
Airini, R., Iordache, F., Alexandru, D., Savu, L., Epureanu, F. B., Mihailescu, D. F., Amuzescu, B. P., & Maniu, H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14495 · Cited by 12 · see citing works
Mesenchymal Stromal Cell Therapy
Neofytou, E. A., Deuse, T., Beygui, R. E., & Schrepfer, S. (2015) · Transplantation · doi:10.1097/tp.0000000000000734 · Cited by 12 · see citing works
Kim, J. Y., Kim, S. H., Seok, J., Bae, S. H., Hwang, S. G., & Kim, G. J. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.01.017 · Cited by 10 · see citing works
Bie, Y., Gu, P., Chen, Y., Zhou, X., Tian, Y.-G., Yang, Q. Z., Li, H., Lin, X., Guan, Y.-H., Lin, T., et al. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1820-8 · Cited by 9 · see citing works
Alrefaei, G. I., Alkarim, S., Ayuob, N. N., & Ali, S. S. (2015) · Tissue and Cell · doi:10.1016/j.tice.2015.05.005 · Cited by 9 · see citing works
Ma, J., Guo, Y., Hu, J., Pan, Y., Xia, Q., Wang, H., & Li, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-25563-w · Cited by 9 · see citing works
The path to biotechnological singularity: Current breakthroughs and outlook
Wen, Z., Yang, D., Yang, Y., Hu, J., Parviainen, A., Chen, X., Li, Q., VanDeusen, E. A., Ma, J., & Tay, F. R. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108667 · Cited by 7 · see citing works
Osteoporosis and Mechanisms of Skeletal Aging
Glowacki, J., & Vokes, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_10 · Cited by 6 · see citing works
Unique Aspects of the Design of Phase I/II Clinical Trials of Stem Cell Therapy
Schulman, I. H., Balkan, W., Saltzman, R., DaFonseca, D., Caceres, L. V., Delgado, C., Pujol, M. V., Ramdas, K. N., Tovar, J. A., Vidro-Casiano, M., et al. (2018) · InTech eBooks · doi:10.5772/intechopen.72949 · Cited by 6 · see citing works
Saldanha, S. N., & Watanabe, L. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800957-4.00018-7 · Cited by 6 · see citing works
Somatic stem cell aging and malignant transformation – impact on therapeutic application
Kuniaková, M., Oravcová, L., Varchulová-Nováková, Z., Viglaska, D., & Danišovič, Ľ. (2015) · Cellular & Molecular Biology Letters · doi:10.1515/cmble-2015-0045 · Cited by 5 · see citing works
Comparative analysis of molecular activity in dermal mesenchymal stem cells from different passages
Li, X., Li, J., Zhao, X., Wang, Q., Yang, X., Cheng, Y., Zhou, M., Wang, G., Dang, E., Yang, X., et al. (2017) · Cell and Tissue Banking · doi:10.1007/s10561-017-9672-z · Cited by 4 · see citing works
Mesenchymal Stromal Cells as a Therapeutic Intervention
Schulman, I. H., & Hare, J. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.78586 · Cited by 4 · see citing works
Matteo, M., Beccia, E., Carbone, A., Castellani, S., Milillo, L., Lauritano, D., Gioia, S. D., Angiolillo, A., & Conese, M. (2019) · Applied Sciences · doi:10.3390/app9173471 · Cited by 2 · see citing works
Aging of Human Mesenchymal Stem Cells
Lepperdinger, G., & Reitinger, S. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1232-8_11 · Cited by 1 · see citing works
Russu, M. C. (2022) · Biochemistry · doi:10.5772/intechopen.108010 · Cited by 1 · see citing works
Perdiguero, E., García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00138-3 · Cited by 1 · see citing works
Perdiguero, E., García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30115-8
Khojah, S. M. (2015) · Enlighten: Theses (The University of Glasgow)
Chakraborty, E., & Shaikh, N. R. (2014)
Allogeneic versus Autologous Source
Taldone, S. N., Schulman, I. H., Balkan, W., & Hare, J. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801888-0.00012-6
Chandra, W. (2016) · International Journal of PharmTech Research
CCR5 deficiency in aged mice causes a decrease in bone mass
Oh, E.-J., Zang, Y., Kim, J.-W., Lee, M. N., Song, J. H., Oh, S., Kwon, S. H., Yang, J., & Koh, J. (2019) · International Journal of Oral Biology · doi:10.11620/ijob.2019.44.4.173
Rasheed, N., Waseem, B., Haneef, K., Usman, S., Sadiq, M., Urooj, T., Tarique, S., & Zeha, D. (2021) · Pakistan Journal of Zoology · doi:10.17582/journal.pjz/20201012081021
The CCL7-CCL2-CCR2 Axis Regulates Age-Related Alterations in ADSCsPreprint
Li, K., Shi, G., Lei, X., Huang, Y., Li, X., Bai, L., & Qin, C. (2021) · Research Square · doi:10.21203/rs.3.rs-390571/v1
Elfita, L., Wientarsih, I., Sajuthi, D., Bachtiar, I., & Darusman, H. S. (2021) · Jurnal Sains Farmasi & Klinis · doi:10.25077/jsfk.8.1.19-26.2021
Activation and Metabolic Shifting: An Essential Process to Mesenchymal Stromal Cells Function
Semedo, P., Pereira, G., de Almeida, D. C., & Câmara, N. O. S. (2023) · Biochemistry · doi:10.5772/intechopen.109273
Studies on Endometrial Mesenchymal Stem Cells in Female Regenerative Pelvic Floor Medicine
Russu, M. C. (2025) · Obstetrics and gynecology. · doi:10.5772/intechopen.1010815
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12457301
Yin, Q., Xu, N., Xu, D., Dong, M., Shi, X., Wang, Y., Hao, Z., Zhu, S., Zhao, D., Jin, H., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12457307
Zheng, W., Xu, W., Li, Y., Qin, J., Zhou, T., Li, D., Xu, Y., Cheng, X., Xiong, Y., & Chen, Z. (2022) · Figshare · doi:10.6084/m9.figshare.21301422
- Authors
- Yu, K.-R., & Kang, K.-S.
- Affiliations
- Seoul National University (KR)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2013
- Volume
- 59
- Issue
- 6
- Pages
- 557-563
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- OpenAlex
- W2031921408
- Cited by
- 103
- References
- 29
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 14 · 2019: 11 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 14 · 2014: 8
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Seoul National University
- Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, stem cell aging, epigenetic regulation, histone acetyltransferase, DNA methyltransferases, p16INK4a, HMGA2, lamin A, prelamin A, nuclear abnormalities, stemness, cell therapy
- MeSH terms
- Aging, Animals, Gene Expression Regulation, Histone Deacetylases, Humans, DNA Modification Methylases, Signal Transduction, Genes, p16, HMGA2 Protein, Lamin Type A, Epigenesis, Genetic, Mesenchymal Stem Cells
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