Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells
Open accessAbstract
BACKGROUND: Mesenchymal stem cells (MSC) are pluripotent cells, present in the bone marrow and other tissues that can differentiate into cells of all germ layers and may be involved in tissue maintenance and repair in adult organisms. Because of their plasticity and accessibility these cells are also prime candidates for regenerative medicine. The contribution of stem cell aging to organismal aging is under debate and one theory is that reparative processes deteriorate as a consequence of stem cell aging and/or decrease in number. Age has been linked with changes in osteogenic and adipogenic potential of MSCs. RESULTS: Here we report on changes in global gene expression of cultured MSCs isolated from the bone marrow of mice at ages 2, 8, and 26-months. Microarray analyses revealed significant changes in the expression of more than 8000 genes with stage-specific changes of multiple differentiation, cell cycle and growth factor genes. Key markers of adipogenesis including lipoprotein lipase, FABP4, and Itm2a displayed age-dependent declines. Expression of the master cell cycle regulators p53 and p21 and growth factors HGF and VEGF also declined significantly at 26 months. These changes were evident despite multiple cell divisions in vitro after bone marrow isolation. CONCLUSIONS: The results suggest that MSCs are subject to molecular genetic changes during aging that are conserved during passage in culture. These changes may affect the physiological functions and the potential of autologous MSCs for stem cell therapy.
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In mouse, bone marrow mesenchymal stem cells had decreased expression of both cell cycle and PCD genes during aging.
“Similarly, in mouse, bone marrow mesenchymal stem cells had decreased expression of both cell cycle and PCD genes during aging(Wilson et al., 2010).”
From Programmed cell death in aging (2015) · cites this paper as Wilson et al., 2010
Aging is associated with decreased PCD in several cell types.
“Aging is associated with decreased PCD in several cell types.”
From Programmed cell death in aging (2015) · cites this paper as Wilson et al., 2010
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- Authors
- Wilson, A., Shehadeh, L. A., Yu, H., & Webster, K. A.
- Affiliations
- University of Miami (US)
- Corresponding author
- Webster, Keith A
- Venue
- BMC Genomics
- Published
- 2010-04-07
- Volume
- 11
- Issue
- 1
- Pages
- 229-229
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC2873471
- OpenAlex
- W2075195897
- Cited by
- 135
- References
- 76
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 15 · 2015: 11 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (HL44578)
- National Heart, Lung, and Blood Institute (HL44578, HL-072924, F32HL083673, R01HL072924)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- mesenchymal stem cells, bone marrow, stem cell aging, biological aging, global gene expression, adipogenesis, osteogenic differentiation, p53, p21, hepatocyte growth factor, vascular endothelial growth factor, lipoprotein lipase, FABP4, ITM2A, cell cycle regulators, growth factors, stem cell therapy
- MeSH terms
- Aging, Animals, Bone Marrow Cells, Cell Cycle, Cells, Cultured, Mice, Inbred C57BL, Gene Expression, Apoptosis, Intercellular Signaling Peptides and Proteins, Mice, Mesenchymal Stem Cells
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