The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis
Abstract
Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.
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In the citing paper
“In addition, preclinical and pharmacokinetic studies indicate that triterpenoid-rich extracts exhibit dose-dependent biological activity despite inherently low bioavailability, supporting the rationale for a moderate dosing strategy [25,53,54,55,56,57].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [53]
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“Eye wrinkle formation was reduced, and biosynthesis of procollagen I, elastin, and fibrillin in the skin was significantly increased in the bioactive collagen peptide-treated group [122].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [122]
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Citations
Cites
The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Suction Blister Device for Separation of Viable Epidermis from Dermis*
Kiistala, U. (1968) · Journal of Investigative Dermatology · doi:10.1038/jid.1968.15 · Cited by 457
Age-related changes in the elastic properties and thickness of human facial skin
Takema, Y., Yorimoto, Y., Kawai, M., & Imokawa, G. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb04975.x · Cited by 340
Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000351376 · Cited by 268
Self-citationNutritional skin care: health effects of micronutrients and fatty acids
Boelsma, E., Hendriks, H., & Roza, L. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.5.853 · Cited by 250
Skin ageing: A comparison between Chinese and European populations
Nouveau-Richard, S., Yang, Z., Mac-Mary, S., Li, L., Bastien, P., Tardy, I., Bouillon, C., Humbert, P., & de Lacharrière, O. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.06.006 · Cited by 231
Contet-Audonneau, Jeanmaire, & Pauly (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02901.x · Cited by 199
Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage
TANAKA, M., KOYAMA, Y.-I., & NOMURA, Y. (2009) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.80649 · Cited by 174
Zague, V., Freitas, V. M., Rosa, M. D. C., de Castro, G. A., Jaeger, R. G., & Machado‐Santelli, G. M. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0085 · Cited by 127
Self-citationEffects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis
Matsuda, N., Koyama, Y., Hosaka, Y. Z., Ueda, H. H., Watanabe, T., ARAYA, T., Irie, S., & TAKEHANA, K. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.211 · Cited by 118
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Puri, V., Nagpal, M., Singh, I., Singh, M., Dhingra, G. A., Huanbutta, K., Dheer, D., Sharma, A., & Sangnim, T. (2022) · Nutrients · doi:10.3390/nu14214637 · Cited by 413
Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515002810 · Cited by 269
Self-citationAsserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12174 · Cited by 260
Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation
Aguirre-Cruz, G., León-López, A., Cruz-Gómez, V., Jiménez-Alvarado, R., & Aguirre‐Álvarez, G. (2020) · Antioxidants · doi:10.3390/antiox9020181 · Cited by 227
Chamcheu, J. C., Roy, T., Uddin, M. B., Banang‐Mbeumi, S., Chamcheu, R. N., Walker, A. L., Liu, Y., & Huang, S. (2019) · Cells · doi:10.3390/cells8080803 · Cited by 212
Metadata
- Authors
- Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Universidade de São Paulo (BR)
- ORCID
- Proksch, E.
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 2013-12-24
- Volume
- 27
- Issue
- 3
- Pages
- 113-119
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W2045543071
- Cited by
- 191
- References
- 27
- Citations by year
- 2026: 25 · 2025: 27 · 2024: 21 · 2023: 17 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 2
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
- Keywords
- skin aging, type I procollagen, elastin, fibrillin, dietary supplements, skin rejuvenation
- MeSH terms
- Fibrillins, Administration, Oral, Aged, Collagen, Double-Blind Method, Elastin, Female, Humans, Microfilament Proteins, Middle Aged, Peptides, Time Factors, Skin Aging, Treatment Outcome, Collagen Type I
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