Cited by 192Skin Protection and AgingCollagen: Extraction and CharacterizationFacial Rejuvenation and Surgery Techniques

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., Oesser, S.·2014·Skin Pharmacology and Physiology

DOI 10.1159/000355523

Open this paper in CoChat — free account

Abstract

Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL® on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol®) reduced skin wrinkles and had positive effects on dermal matrix synthesis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1159/000355523

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The extracellular matrix at a glance
Frantz, C., Stewart, K. M., & Weaver, V. M. (2010) · Journal of Cell Science · doi:10.1242/jcs.023820 · Cited by 4,334
Suction Blister Device for Separation of Viable Epidermis from Dermis*
Kiistala, U. (1968) · Journal of Investigative Dermatology · doi:10.1038/jid.1968.15 · Cited by 457
Age-related changes in the elastic properties and thickness of human facial skin
Takema, Y., Yorimoto, Y., Kawai, M., & Imokawa, G. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb04975.x · Cited by 340
Oral Supplementation of Specific Collagen Peptides Has Beneficial Effects on Human Skin Physiology: A Double-Blind, Placebo-Controlled Study
Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V., & Oesser, S. (2013) · Skin Pharmacology and Physiology · doi:10.1159/000351376 · Cited by 268
Self-citation
Nutritional skin care: health effects of micronutrients and fatty acids
Boelsma, E., Hendriks, H., & Roza, L. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.5.853 · Cited by 249
Skin ageing: A comparison between Chinese and European populations
Nouveau-Richard, S., Yang, Z., Mac-Mary, S., Li, L., Bastien, P., Tardy, I., Bouillon, C., Humbert, P., & de Lacharrière, O. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.06.006 · Cited by 231
A histological study of human wrinkle structures: comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas
Contet-Audonneau, Jeanmaire, & Pauly (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02901.x · Cited by 199
Effects of Collagen Peptide Ingestion on UV-B-Induced Skin Damage
TANAKA, M., KOYAMA, Y.-I., & NOMURA, Y. (2009) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.80649 · Cited by 174
Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Metalloproteinase 2 Activity
Zague, V., Freitas, V. M., Rosa, M. D. C., de Castro, G. A., Jaeger, R. G., & Machado‐Santelli, G. M. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.0085 · Cited by 127
Self-citation
Effects of Ingestion of Collagen Peptide on Collagen Fibrils and Glycosaminoglycans in the Dermis
Matsuda, N., Koyama, Y., Hosaka, Y. Z., Ueda, H. H., Watanabe, T., ARAYA, T., Irie, S., & TAKEHANA, K. (2006) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.52.211 · Cited by 118

Flagged first, then by citations

Show all 27 references

Sorted by citations

A Comprehensive Review on Nutraceuticals: Therapy Support and Formulation Challenges
Puri, V., Nagpal, M., Singh, I., Singh, M., Dhingra, G. A., Huanbutta, K., Dheer, D., Sharma, A., & Sangnim, T. (2022) · Nutrients · doi:10.3390/nu14214637 · Cited by 413
Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial
Zdzieblik, D., Oesser, S., Baumstark, M. W., Gollhofer, A., & König, D. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515002810 · Cited by 269
Self-citation
The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo‐controlled clinical trials
Asserin, J., Lati, E., Shioya, T., & Prawitt, J. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12174 · Cited by 260
Collagen Hydrolysates for Skin Protection: Oral Administration and Topical Formulation
Aguirre-Cruz, G., León-López, A., Cruz-Gómez, V., Jiménez-Alvarado, R., & Aguirre‐Álvarez, G. (2020) · Antioxidants · doi:10.3390/antiox9020181 · Cited by 227
Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy
Chamcheu, J. C., Roy, T., Uddin, M. B., Banang‐Mbeumi, S., Chamcheu, R. N., Walker, A. L., Liu, Y., & Huang, S. (2019) · Cells · doi:10.3390/cells8080803 · Cited by 212
A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study
Bolke, L., Schlippe, G., Gerß, J., & Voss, W. (2019) · Nutrients · doi:10.3390/nu11102494 · Cited by 223
The review of versatile application of collagen
Sionkowska, A., Skrzyński, S., Śmiechowski, K., & Kołodziejczak, A. (2016) · Polymers for Advanced Technologies · doi:10.1002/pat.3842 · Cited by 191
Nutraceuticals for Skin Care: A Comprehensive Review of Human Clinical Studies
Pérez-Sánchez, A., Barrajón‐Catalán, E., Herranz‐López, M., & Micol, V. (2018) · Nutrients · doi:10.3390/nu10040403 · Cited by 194
Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta‐analysis
de MIRANDA, R. B., Weimer, P., & Rossi, R. C. (2021) · International Journal of Dermatology · doi:10.1111/ijd.15518 · Cited by 173
Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome
Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132
Collagen peptides and the related synthetic peptides: A review on improving skin health
Zhao, X., Zhang, X., & Liu, D. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104680 · Cited by 133
Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double‐blind placebo‐controlled clinical study
Inoue, N., Sugihara, F., & Wang, X. (2016) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7606 · Cited by 126
Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis
PU, S.-Y., Huang, Y.-L., Pu, C., Kang, Y., Hoang, K. D., Chen, K., & Chen, C. (2023) · Nutrients · doi:10.3390/nu15092080 · Cited by 141
The impact of collagen protein ingestion on musculoskeletal connective tissue remodeling: A narrative review
Holwerda, A. M., & van Loon, L. J. C. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuab083 · Cited by 117
“It has been proposed that the hydrolyzation of collagenderived proteins produces peptides, which may act to further enhance connective tissue remodeling in musculoskeletal and dermal tissues.(104,106,107) To have any stimulatory or inhibitory properties, the ingested peptides must be absorbed in their intact form into…”
Background
Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing
Czajka, A., Kania, E. M., Genovese, L., Corbo, A., Merone, G., Luci, C., & Sibilla, S. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.06.001 · Cited by 132
Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116
Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant‐Derived Antioxidants: A Single‐Blind Case‐Control Clinical Study
Luca, C. D., Mikhalchik, E. V., Suprun, M. V., Papacharalambous, M., Truhanov, A. I., & Korkina, L. G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4389410 · Cited by 112
A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity
Evans, M., Lewis, E. D., Zakaria, N., Pelipyagina, T., & Guthrie, N. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13676 · Cited by 102
Bovine Collagen Peptides Compounds Promote the Proliferation and Differentiation of MC3T3-E1 Pre-Osteoblasts
Liu, J., Zhang, B., Song, S., Ma, M., Si, S., Wang, Y., Xu, B., Feng, K., Wu, J., & Guo, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099920 · Cited by 96
Beyond photoaging: additional factors involved in the process of skin aging
Addor, F. A. S. (2018) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s177448 · Cited by 98
Plant and Microalgae Derived Peptides Are Advantageously Employed as Bioactive Compounds in Cosmetics
Apone, F., Barbulova, A., & Colucci, M. G. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00756 · Cited by 90
Food-derived bioactive peptides: production, biological activities, opportunities and challenges
Ye, H., Tao, X., Zhang, W., Chen, Y., Yu, Q., & Xie, J. (2022) · Journal of Future Foods · doi:10.1016/j.jfutfo.2022.08.002 · Cited by 87
Collagen supplementation for skin health: A mechanistic systematic review
Barati, M., Jabbari, M., Navekar, R., Farahmand, F., Zeinalian, R., Salehi‐Sahlabadi, A., Abbaszadeh, N., Mokari‐Yamchi, A., & Davoodi, S. H. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13435 · Cited by 89
Use of Collagen in Cosmetic Products
Jadach, B., Mielcarek, Z., & Osmałek, T. Z. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030132 · Cited by 97
Oral Intake of Chicken Bone Collagen Peptides Anti-Skin Aging in Mice by Regulating Collagen Degradation and Synthesis, Inhibiting Inflammation and Activating Lysosomes
Cao, C., Xiao, Z., Tong, H., Liu, Y., Wu, Y., & Ge, C. (2022) · Nutrients · doi:10.3390/nu14081622 · Cited by 80
Collagen Structure, Synthesis, and Its Applications: A Systematic Review
Shenoy, M., Abdul, N. S., Qamar, Z., Bahri, B. M. A., Ghalayini, K. Z. K. A., & Kakti, A. (2022) · Cureus · doi:10.7759/cureus.24856 · Cited by 82
An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants
Genovese, L., Corbo, A., & Sibilla, S. (2017) · Skin Pharmacology and Physiology · doi:10.1159/000464470 · Cited by 80
Effects of Composite Supplement Containing Collagen Peptide and Ornithine on Skin Conditions and Plasma IGF-1 Levels—A Randomized, Double-Blind, Placebo-Controlled Trial
Ito, N., Seki, S., & Ueda, F. (2018) · Marine Drugs · doi:10.3390/md16120482 · Cited by 77
The effect of collagen hydrolysates from silver carp (Hypophthalmichthys molitrix) skin on UV-induced photoaging in mice: Molecular weight affects skin repair
Song, H., Meng, M., Cheng, X., Li, B., & Wang, C. (2017) · Food & Function · doi:10.1039/c6fo01397j · Cited by 66
Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice
Han, H.-S., Shin, J., Myung, D.-B., Ahn, H. S., Lee, S. H., Kim, H. J., & Lee, K. (2019) · Nutrients · doi:10.3390/nu11030533 · Cited by 64
Ingestion of an oral hyaluronan solution improves skin hydration, wrinkle reduction, elasticity, and skin roughness: Results of a clinical study
Göllner, I., Voss, W., von Hehn, U., & Kammerer, S. (2017) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587217743640 · Cited by 54
Comparison of in vivo and ex vivo laser scanning microscopy and multiphoton tomography application for human and porcine skin imaging
Darvin, M. E., Richter, H., Zhu, Y., Meinke, M. C., Knorr, F., Gonchukov, S. A., Koenig, K., & Lademann, J. M. (2014) · Quantum Electronics · doi:10.1070/qe2014v044n07abeh015488 · Cited by 51
Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails
Hexsel, D. M., Zague, V., Schunck, M., Siega, C., Camozzato, F. O., & Oesser, S. (2017) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12393 · Cited by 49
Self-citation
Collagen peptides modulate the metabolism of extracellular matrix by human dermal fibroblasts derived from sun‐protected and sun‐exposed body sites
Zague, V., do Amaral, J. B., Teixeira, P. R., Niero, E. L. D. O., Lauand, C., & Machado‐Santelli, G. M. (2017) · Cell Biology International · doi:10.1002/cbin.10872 · Cited by 51
Self-citation
Food-Derived Collagen Peptides, Prolyl-Hydroxyproline (Pro-Hyp), and Hydroxyprolyl-Glycine (Hyp-Gly) Enhance Growth of Primary Cultured Mouse Skin Fibroblast Using Fetal Bovine Serum Free from Hydroxyprolyl Peptide
Asai, T. T., Oikawa, F., Yoshikawa, K., Inoue, N., & Sato, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010229 · Cited by 48
Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology
Schunck, M., Zague, V., Oesser, S., & Proksch, E. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2015.0022 · Cited by 46
Self-citation
Changes in composition and content of food‐derived peptide in human blood after daily ingestion of collagen hydrolysate for 4 weeks
Shigemura, Y., Suzuki, A., Kurokawa, M., Satō, Y., & Sato, K. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8677 · Cited by 45
Effects of a Combination of Water-Soluble Coenzyme Q10 and Collagen on Skin Parameters and Condition: Results of a Randomised, Placebo-Controlled, Double-Blind Study
Žmitek, K., Žmitek, J., Butina, M. R., & Pogačnik, T. (2020) · Nutrients · doi:10.3390/nu12030618 · Cited by 47
Oral Supplementation of Collagen Peptides Improves Skin Hydration by Increasing the Natural Moisturizing Factor Content in the Stratum Corneum: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Miyanaga, M., Uchiyama, T., Motoyama, A., Ochiai, N., Ueda, O., & Ogo, M. (2021) · Skin Pharmacology and Physiology · doi:10.1159/000513988 · Cited by 44
Amount of Collagen in the Meat Contained in Japanese Daily Dishes and the Collagen Peptide Content in Human Blood after Ingestion of Cooked Fish Meat
Asai, T. T., Takahashi, A., Ito, K., Uetake, T., Matsumura, Y., Ikeda, K., Inagaki, N., Nakata, M., Imanishi, Y., & Sato, K. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06896 · Cited by 43
Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts
Dierckx, S., Patrizi, M., Merino, M., González, S., Mullor, J. L., & Nergiz‐Unal, R. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1397517 · Cited by 51
Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study
Lee, M., Kim, E., Ahn, H., Son, S., & Lee, H.-J. (2023) · Food & Function · doi:10.1039/d2fo02958h · Cited by 41
Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study
Kim, J., Lee, S. G., Lee, J.-H., Choi, S., Suk, J., Lee, J. H., Yang, J. H., Yang, J. S., & Kim, J. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2022.k.0097 · Cited by 41
The presence of food-derived collagen peptides in human body-structure and biological activity
Sato, K. (2017) · Food & Function · doi:10.1039/c7fo01275f · Cited by 40
Identification of food-derived peptides in human blood after ingestion of corn and wheat gluten hydrolysates
Ejima, A., Nakamura, M., Suzuki, Y. A., & Sato, K. (2018) · Journal of Food Bioactives · doi:10.31665/jfb.2018.2145 · Cited by 40
Effects of Dietary Supplementation with Fish Scales-Derived Collagen Peptides on Skin Parameters and Condition: A Randomized, Placebo-Controlled, Double-Blind Study
Koizumi, S., Inoue, N., Shimizu, M., Kwon, C., Kim, H.-Y., & Park, K. S. (2017) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-017-9626-0 · Cited by 38
The role of diet in managing menopausal symptoms: A narrative review
Yelland, S., Steenson, S., Creedon, A., & Stanner, S. A. (2023) · Nutrition Bulletin · doi:10.1111/nbu.12607 · Cited by 41
Impact of Body Site, Age, and Gender on the Collagen/Elastin Index by Noninvasive in vivo Vertical Two-Photon Microscopy
Czekalla, C., Schönborn, K., Döge, N., Jung, S., Darvin, M. E., Lademann, J. M., & Meinke, M. C. (2017) · Skin Pharmacology and Physiology · doi:10.1159/000477854 · Cited by 34
Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis
Song, H., Zhang, L., Luo, Y., Zhang, S., & Лі, Б. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13317 · Cited by 34
Effect of Collagen Tripeptide and Adjusting for Climate Change on Skin Hydration in Middle-Aged Women: A Randomized, Double-Blind, Placebo-Controlled Trial
Tak, Y. J., Shin, D. K., Kim, A. H., Kim, J. I., Lee, Y. L., Ko, H., Kim, Y.-W., & Lee, S. Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.608903 · Cited by 34
Influences of Orally Taken Carotenoid-Rich Curly Kale Extract on Collagen I/Elastin Index of the Skin
Meinke, M. C., Nowbary, C., Schanzer, S., Vollert, H., Lademann, J. M., & Darvin, M. E. (2017) · Nutrients · doi:10.3390/nu9070775 · Cited by 33
Regulation by walnut protein hydrolysate on the components and structural degradation of photoaged skin in SD rats
Xu, D., Li, D., Zhao, Z., Wu, J., & Zhao, M. (2019) · Food & Function · doi:10.1039/c8fo01833b · Cited by 32
AP Collagen Peptides Prevent Cortisol-Induced Decrease of Collagen Type I in Human Dermal Fibroblasts
Chae, M., Bae, I., Lim, S.-H., Jung, K.-M., Roh, J., & Kim, W.-G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094788 · Cited by 30
Attenuation of UV-induced skin photoaging in rats by walnut protein hydrolysates is linked to the modulation of MAPK/AP-1 and TGF-β/Smad signaling pathways
Xu, D., Li, C., & Zhao, M. (2021) · Food & Function · doi:10.1039/d1fo02598h · Cited by 30
Detection of endogenous and food-derived collagen dipeptide prolylhydroxyproline (Pro-Hyp) in allergic contact dermatitis-affected mouse ear
Kusubata, M., Koyama, Y., Tometsuka, C., Shigemura, Y., & Sato, K. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1027653 · Cited by 29
Walnut protein hydrolysates, rich with peptide fragments of WSREEQEREE and ADIYTEEAGR ameliorate UV-induced photoaging through inhibition of the NF-κB/MMP-1 signaling pathway in female rats
Xu, D., Wang, W., Liao, J., Liao, L., Li, C., & Zhao, M. (2020) · Food & Function · doi:10.1039/d0fo02027c · Cited by 29
An Oral Supplementation Based on Hydrolyzed Collagen and Vitamins Improves Skin Elasticity and Dermis Echogenicity: A Clinical Placebo-Controlled Study
PatrAAcia Maia Campos, M. B. G. (2015) · Clinical Pharmacology & Biopharmaceutics · doi:10.4172/2167-065x.1000142 · Cited by 29
Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway
Jiang, H., Zhou, X., & Chen, L. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11603 · Cited by 27
Collagen: New Dimension in Cosmetic and Healthcare
Samad, N., & Sikarwar, A. (2016) · International Journal of Biochemistry Research & Review · doi:10.9734/ijbcrr/2016/27271 · Cited by 27
Protective effects of Quercus acuta Thunb. fruit extract against UVB-induced photoaging through ERK/AP-1 signaling modulation in human keratinocytes
Hong, J., Bae, D., Oh, K.-N., Oh, D.-R., Kim, Y.-J., Kim, Y., Im, S. J., Choi, E.-J., Lee, S., Kim, M., et al. (2022) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-021-03473-1 · Cited by 26
A Pilot Study for the Detection of Cyclic Prolyl-Hydroxyproline (Pro-Hyp) in Human Blood after Ingestion of Collagen Hydrolysate
Shigemura, Y., Iwasaki, Y., Tateno, M., Suzuki, A., Kurokawa, M., Satō, Y., & Sato, K. (2018) · Nutrients · doi:10.3390/nu10101356 · Cited by 26
The effect of different molecular weight collagen peptides on MC3T3-E1 cells differentiation
Liu, J., Si, S., Qin, Y., Zhang, B., Song, S., & Guo, Y. (2015) · Bio-Medical Materials and Engineering · doi:10.3233/bme-151509 · Cited by 25
Long-term intake of ginger protease-degraded collagen hydrolysate reduces blood lipid levels and adipocyte size in mice
Tometsuka, C., Funato, N., Mizuno, K., & Taga, Y. (2021) · Current Research in Food Science · doi:10.1016/j.crfs.2021.03.003 · Cited by 25
An endostatin-derived peptide orally exerts anti-fibrotic activity in a murine pulmonary fibrosis model
Nishimoto, T., Mlakar, L., Takihara, T., & Feghali‐Bostwick, C. A. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.07.039 · Cited by 25
Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation
Prokopová, A., Pavlačková, J., Mokrejš, P., & Gál, R. (2021) · Molecules · doi:10.3390/molecules26072021 · Cited by 26
Effects of oral administration of collagen peptides on skin collagen content and its underlying mechanism using a newly developed low collagen skin mice model
Haratake, A., Watase, D., Fujita, T., Setoguchi, S., Matsunaga, K., & Takata, J. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.04.017 · Cited by 23
Chia derived bioactive peptides: Extraction, characterization, pharmacological activities and potential food applications
Mensah, E. O., Nadtochii, L. A., Adadi, P., & Agyei, D. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103975 · Cited by 25
Generation of bioactive prolyl‐hydroxyproline (Pro‐Hyp) by oral administration of collagen hydrolysate and degradation of endogenous collagen
Sato, K., Jimi, S., & Kusubata, M. (2019) · International Journal of Food Science & Technology · doi:10.1111/ijfs.14145 · Cited by 22
Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis
Oba, C., Ito, K., Ichikawa, S., Morifuji, M., Nakai, Y., Ishijima, T., Abe, K., & Kawahata, K. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00009.2015 · Cited by 19
A single-center, randomized, double-blind, placebo-controlled study on the efficacy and safety of “enzyme-treated red ginseng powder complex (BG11001)” for antiwrinkle and proelasticity in individuals with healthy skin
Park, S., Shin, Y., Kim, H.-T., Kim, Y. M., Lee, D., Hwang, E., Cho, B.-G., Yin, C. S., Kim, K.-Y., & Yi, T. (2015) · Journal of Ginseng Research · doi:10.1016/j.jgr.2015.08.006 · Cited by 18
The effect of oral supplements containing collagen peptides rich in X-Hyp or X-Hyp-Gly compared with normal collagen hydrolysates on skin elasticity and collagen holes: a randomised double-blind clinical study
Chen, L., Lv, Y., Xu, F., & Zhong, F. (2023) · Food & Function · doi:10.1039/d3fo02873a · Cited by 17
Effects of Food-Derived Collagen Peptides on the Expression of Keratin and Keratin-Associated Protein Genes in the Mouse Skin
Vu, P. L., Takatori, R., Iwamoto, T., Akagi, Y., Satsu, H., Totsuka, M., Chida, K., Sato, K., & Shimizu, M. (2015) · Skin Pharmacology and Physiology · doi:10.1159/000369830 · Cited by 18
The Skin Aging Process and Anti-Aging Strategies
Pathak, Y. V. (2022) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2022.42.006712 · Cited by 19
Skin health and integrity
Kottner, J., Beeckman, D., Vogt, A., & Blume‐Peytavi, U. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815028-3.00011-0 · Cited by 15
Food-derived skin-care ingredient as a promising strategy for skin aging: Current knowledge and future perspectives
Jin, Z., Zhang, P., Huang, H., Liu, J., Jiang, C., Zhang, H., Ren, L., Sun, B., Chang, X., Gao, T., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114170 · Cited by 15
Theragra chalcogramma Hydrolysate, Rich in Gly-Leu-Pro-Ser-Tyr-Thr, Alleviates Photoaging via Modulating Deposition of Collagen Fibers and Restoration of Extracellular Components Matrix in SD Rats
Xu, D., Li, C., & Zhao, M. (2022) · Marine Drugs · doi:10.3390/md20040252 · Cited by 13
Nutraceuticals and skin appearance: Is there any evidence to support this growing trend?
Spiro, A., & Lockyer, S. (2018) · Nutrition Bulletin · doi:10.1111/nbu.12304 · Cited by 13
Hydrolysis Process Optimization and Functional Characterization of Yak Skin Gelatin Hydrolysates
Yang, H., Xue, Y., Liu, J., Song, S., Zhang, L., Song, Q., Tian, L., He, X., He, S., & Zhu, H. (2019) · Journal of Chemistry · doi:10.1155/2019/9105605 · Cited by 13
Effects of Collagen Ingestion and their Biological Significance
Koyama, Y. (2016) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000504 · Cited by 13
The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin Density, Texture and Other Parameters: A Randomised, Double-Blind, Placebo-Controlled Trial
Žmitek, K., Žmitek, J., Hristov, H., Butina, M. R., Keršmanc, P., & Pogačnik, T. (2024) · Nutrients · doi:10.3390/nu16121908 · Cited by 22
Influence of collagen peptide supplementation on visible signs of skin and nail health and ‐aging in an East Asian population: A double blind, randomized, placebo‐controlled trial
Vleminckx, S., Virgilio, N., Asserin, J., Prawitt, J., & Silva, C. I. F. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16458 · Cited by 15
Optimization of dose of collagen hydrolysate to prevent UVB-irradiated skin damage
Jimbo, N., Kawada, C., & Nomura, Y. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1086258 · Cited by 12
Effect of orally ingested diosgenin into diet on skin collagen content in a low collagen skin mouse model and its mechanism of action
Haratake, A., Watase, D., Setoguchi, S., Nagata‐Akaho, N., Matsunaga, K., & Takata, J. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.013 · Cited by 12
Mouse skin fibroblasts with mesenchymal stem cell marker p75 neurotrophin receptor proliferate in response to prolyl-hydroxyproline
Asai, T. T., Yoshikawa, K., Sawada, K., Fukamizu, K., Koyama, Y., Shigemura, Y., Jimi, S., & Sato, K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103792 · Cited by 12
Hydrolyzed collagen, KCl, and arginine: A successful strategy to reduce fat and sodium while maintaining the physicochemical, sensory, and shelf life quality of mortadella
Correa, L. P., Pinton, M. B., dos Santos, B. A., Morgano, M. A., Vargas‐Ramella, M., Cichoski, A. J., Wagner, R. C., & Campagnol, P. C. B. (2025) · Meat Science · doi:10.1016/j.meatsci.2025.109775 · Cited by 11
Hydrolyzed Collagen Combined with Djulis and Green Caviar Improve Skin Condition: A Randomized, Placebo-Controlled Trial
Chang, H.-C., Lin, Y.-K., Lin, Y., Lin, Y.-H., Hu, W., & Chiang, C. (2021) · Current Research in Nutrition and Food Science Journal · doi:10.12944/crnfsj.9.2.16 · Cited by 11
A micronutrient mixture with collagen peptides, probiotics, cannabidiol, and diet may reduce aging, and development and progression of age-related alzheimer’s disease, and improve its treatment
Prasad, K. N. (2022) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2022.111757 · Cited by 13
The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness
Oesser, S. (2020) · Nutrafoods · Cited by 11
Self-citation
Beneficial Effects of Multi-Micronutrient Supplementation with Collagen Peptides on Global Wrinkles, Skin Elasticity and Appearance in Healthy Female Subjects
Gibson, R., Krug, L., Ramsey, D. L., Safaei, A., & Aspley, S. (2024) · Dermatology and Therapy · doi:10.1007/s13555-024-01184-2 · Cited by 14
Chikusetsusaponin IVa from Dolichos lablab Linne attenuates UVB-induced skin photoaging in mice by suppressing MAPK/AP-1 signaling
Kim, K. M., Im, A., Shim, K., Seo, C., Lee, Y., Lee, J. H., Yoo, J. S., Choi, S., & Chae, S. (2024) · Applied Biological Chemistry · doi:10.1186/s13765-024-00934-2 · Cited by 12
Efficacy of a collagen hydrolysate and antioxidants-containing nutraceutical on metrics of skin health in Indian women
Motwani, M. S., Khan, K., Pai, A., & Joshi, R. (2020) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.13404 · Cited by 9
Low-Molecular Collagen Peptide Supplementation and Body Fat Mass in Adults Aged ≥ 50 Years: A Randomized, Double-Blind, Placebo-Controlled Trial
Park, J., Kim, M., Shin, H., Ahn, H., & Park, Y. K. (2023) · Clinical Nutrition Research · doi:10.7762/cnr.2023.12.4.245 · Cited by 9
Dietary interventions in skin ageing: a systematic review and meta-analysis
Ng, J. Y., Min, G. Y. N. X., Wong, Q. Y. A., & Chew, F. T. (2025) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-025-00408-4 · Cited by 13
Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials
Yang, Q., Li, H., Zhang, H., Ma, L., Zhang, X., & Wu, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1582946 · Cited by 9
Oral intake of collagen hydrolysate from mackerel scad ( Decapterus macarellus ) attenuates skin photoaging by suppressing the UVB-induced expression of MMP-1 and IL-6
Titisari, R. S., Herawati, E., & Astirin, O. P. (2023) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2023-0209 · Cited by 11
Effects of 8 Weeks of Shilajit Supplementation on Serum Pro-c1α1, a Biomarker of Type 1 Collagen Synthesis: A Randomized Control Trial
Neltner, T. J., Sahoo, P. K., SMITH, R. W., Anders, J. P. V., Arnett, J. E., Schmidt, R. J., Johnson, G. O., Natarajan, S. K., & Housh, T. J. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2157522 · Cited by 10
The effect of a 12-week dietary intake of food supplements containing collagen and MSM on dermis density and other skin parameters: A double-blind, placebo-controlled, randomised four-way study comparing the efficacy of three test products
Pogačnik, T., Žmitek, J., Hristov, H., Keršmanc, P., Butina, M. R., & Žmitek, K. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105838 · Cited by 8
Liquid collagen from freshwater fish skin ameliorates hydration, roughness and elasticity in photo-aged skin: a randomized, controlled, clinical study
Lee, J. S., Yoon, Y. C., Kim, J. M., Kim, Y.-H., Kang, Y., & Shin, Y. C. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.3.357 · Cited by 7
Efficacy and Safety of Topical or Oral Hydrolyzed Collagen in Women with Dermatoporosis: A Randomized, Double-Blind, Factorial Design Study
Guadanhim, L. R. D. S., Miot, H. A., Soares, J. L. M., Silva, S. A. M. E., Leonardi, G. R., Lópes, R. D., & Bagatin, E. (2022) · Dermatology and Therapy · doi:10.1007/s13555-022-00859-y · Cited by 10
Cytokine-Related Effect of Buccal-Delivered Collagen Peptide Incorporated in Mucoadhesive Films to Improve Female Skin Conditions
Kim, Y. H., Im, D., Lee, K., Yoon, S., & Ham, Y. B. (2021) · Applied Sciences · doi:10.3390/app11167486 · Cited by 7

Authors: Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S.
Affiliations: Christian-Albrechts-Universität zu Kiel (DE)
Universidade de São Paulo (BR)
ORCID: Proksch, E.
Venue: Skin Pharmacology and Physiology
Publisher: S. Karger AG
Published: 2013-12-24
Volume: 27
Issue: 3
Pages: 113-119
ISSN: 1422-2868 (ISSN-L)
1660-5527
1660-5535
DOI: 10.1159/000355523
OpenAlex: W2045543071
Cited by: 191
References: 27
Citations by year: 2026: 25 · 2025: 27 · 2024: 21 · 2023: 17 · 2022: 18 · 2021: 16 · 2020: 14 · 2019: 11 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 14 · 2014: 2
FWCI: 8.22
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Skin Pharmacology and Physiology (publishedVersion)
PubMed (publishedVersion)
Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel) (submittedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords: skin aging, type I procollagen, elastin, fibrillin, dietary supplements, skin rejuvenation
MeSH terms: Fibrillins, Administration, Oral, Aged, Collagen, Double-Blind Method, Elastin, Female, Humans, Microfilament Proteins, Middle Aged, Peptides, Time Factors, Skin Aging, Treatment Outcome, Collagen Type I

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks