Selenium supplementation for Hashimoto's thyroiditis: summary of a Cochrane systematic review
Open accessAbstract
Selenium supplementation in people with Hashimoto's thyroiditis might reduce antibody levels and result in a decreased dosage of levothyroxine (LT4) and may provide other beneficial effects (e.g. on mood and health-related quality of life). The aim of our systematic review was to assess the effects of selenium supplementation on Hashimoto's thyroiditis. We searched The Cochrane Library, MEDLINE, EMBASE and Web of Science for randomized controlled trials. Study selection, data extraction, assessment of risk of bias and analyses were carried out by two independent review authors. We assessed the quality of the evidence of included studies using GRADE. Four studies rated at unclear to high risk of bias comprising 463 participants were included. One study at high risk of bias showed statistically significant improvement in subjective well-being with sodium selenite 200 μg plus titrated LT4 compared with placebo plus titrated LT4 (RR 4.67, 95% CI 1.61-13.50). Selenomethionine 200 μg as a single treatment or combined with LT4 reduced the serum levels of anti-thyroid peroxidase antibodies compared with placebo (or placebo plus LT4) in three studies (p < 0.001). Although the changes from baseline were statistically significant in these three studies, their clinical relevance is unclear. In conclusion, the results of these four studies, assessed at unclear to high risk of bias, show that evidence to support or refute the efficacy of selenium supplementation in people with Hashimoto's thyroiditis is incomplete and not reliable to help inform clinical decision making.
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Selenium might have a role in reducing TPO-Ab concentrations, although results and potential benefits from selenium supplementation studies have been inconsistent.
“Selenium might have a role in reducing TPO-Ab concentrations, 168,169 although results and potential benefits from selenium supplementation studies have been inconsistent.170”
From Hypothyroidism (2024) · cites this paper as [170]
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- Authors
- van Zuuren, E. J., Albusta, A. Y., Fedorowicz, Z., Carter, B., & Pijl, H.
- Affiliations
- 1
- University of Technology Bahrain (BH)
- Cochrane Canada (CA)
- 5
- Leiden University Medical Center (NL)
- Venue
- European Thyroid Journal
- Publisher
- Bioscientifica
- Published
- 2013-11-21
- Volume
- 3
- Issue
- 1
- Pages
- 25-31
- ISSN
- 2235-0640 (ISSN-L)
- 2235-0802
- PMC
- PMC4005265
- OpenAlex
- W2035024811
- Cited by
- 65
- References
- 22
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 7 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 3 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 7
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Thyroid Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- selenium supplementation, Hashimoto's thyroiditis, autoimmune thyroid disease, thyroid peroxidase antibodies, levothyroxine, selenomethionine, sodium selenite, health-related quality of life, mood, risk of bias
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