The DOI matches its Crossref record; 107 of the 108 references it cites were found in a registry or an index.
Placental Pathology in Early-Onset and Late-Onset Fetal Growth Restriction
Abstract
Several histopathological features are found more frequently in placentas from pregnancies complicated by fetal growth restriction (FGR), including villous infarction, maternal vascular changes and villous morphological alterations, although around one quarter of placentas associated with FGR lack any morphological abnormality on routine examination. Since similar changes may also affect clinically uncomplicated pregnancies, the positive predictive value of such findings for pathological FGR in an unselected case remains low. However, the pattern of placental pathologies varies with clinical subgroup. The combination of placental bed and parenchymal lesions in FGR with abnormal uterine artery Doppler velocimetry is essentially identical to preterm pre-eclampsia (PET), and there is an association between FGR with abnormal umbilical artery Doppler findings and lesions of fetal stem arteries and terminal villous hypovascularity. Conversely, placentas from pregnancies complicated by PET or FGR presenting at or near term have a significantly lower frequency of histological abnormalities compared to early-onset disease and absence of a distinctive biochemical profile. The histological placental findings in FGR are therefore varied, from morphologically unremarkable through to severe uteroplacental vasculopathy, with no single pathological feature associated with high sensitivity or specificity. Severe early-onset FGR, overlapping with severe early-onset PET, is mainly associated with features of impaired maternal uteroplacental perfusion secondary to defective extravillous trophoblast invasion, and its consequences. Late-onset FGR probably represents a more heterogeneous group with less characteristic histological changes. Future research using histopathological assessment of aggregated data from multiple studies into larger datasets with centralised pathology review will allow delineation of distinctive clinicopathological associations and further understanding of pathophysiology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These challenges are exacerbated in high-risk cohorts, including pregnancies complicated by hypertensive disorders of pregnancy (HDP), where placental insufficiency disrupts fetal lung maturation through hypoxia-mediated pathways (4).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [4]
Citations
Cites
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
NCBI GEO: archive for functional genomics data sets—update
Barrett, T., Wilhite, S. E., Ledoux, P., Evangelista, C., Kim, I. F., Tomashevsky, M., Marshall, K. A., Phillippy, K. H., Sherman, P. M., Holko, M., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1193 · Cited by 10,418
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720
Circulating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics and Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,623
KHONG, T. Y., DE WOLF, F., ROBERTSON, W. B., & BROSENS, I. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07830.x · Cited by 1,591
Pre-eclampsia: more than pregnancy-induced hypertension
Roberts, J. M., & Redman, C. W. G. (1993) · The Lancet · doi:10.1016/0140-6736(93)90889-o · Cited by 1,239
The role of the spiral arteries in the pathogenesis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 953
Romero, R. J., Nien, J. K., Espinoza, J., Todem, D., Fu, W., Chung, H., Kusanovic, J. P., Gotsch, F., Erez, O., Mazaki‐Tovi, S., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701830480 · Cited by 683
Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns
Redline, R. W., Faye-Petersen, O. M., Heller, D. S., Qureshi, F., Savell, V., & Vogler, C. A. (2003) · Pediatric and Developmental Pathology · doi:10.1007/s10024-003-7070-y · Cited by 674
Cited by
Sorted by citations
Consensus definition of fetal growth restriction: a Delphi procedure: Consensus definition of FGR
Gordijn, S. J., Beune, I. M., Thilaganathan, B., Papageorghiou, A., Baschat, A. A., Baker, P. N., Silver, R. M., Wynia, K., & Ganzevoort, W. (2016) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.15884 · Cited by 1,638
Pathophysiology of placental-derived fetal growth restriction
Burton, G. J., & Jauniaux, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.577 · Cited by 1,070
Lees, C. C., Stampalija, T., Baschat, A. A., da Silva Costa, F., Ferrazzi, E., Figueras, F., Hecher, K., Kingdom, J., Poon, L. C., Salomon, L. J., et al. (2020) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.22134 · Cited by 886
Melamed, N., Baschat, A., Yinon, Y., Athanasiadis, A. P., Mecacci, F., Figueras, F., Berghella, V., Nazareth, A., Tahlak, M., McIntyre, D. H., et al. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13522 · Cited by 629
Diagnosis and surveillance of late-onset fetal growth restriction
Figueras, F., Caradeux, J., Crispi, F., Eixarch, E., Peguero, A., & Gratacos, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.003 · Cited by 300
Metadata
- Authors
- Mifsud, W., & Sebire, N. J.
- Affiliations
- Great Ormond Street Hospital (GB)
- Corresponding author
- Sebire, Neil J.
- Venue
- Fetal Diagnosis and Therapy
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 36
- Issue
- 2
- Pages
- 117-128
- ISSN
- 1015-3837 (ISSN-L)
- 1421-9964
- OpenAlex
- W2084099835
- Cited by
- 328
- References
- 108
- Citations by year
- 2026: 17 · 2025: 20 · 2024: 29 · 2023: 40 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 26 · 2018: 40 · 2017: 16 · 2016: 18 · 2015: 13 · 2014: 3
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Fetal Diagnosis and Therapy (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
- Keywords
- placental pathology, fetal growth restriction, early-onset fetal growth restriction, late-onset fetal growth restriction, preterm preeclampsia, uterine artery Doppler, umbilical artery Doppler, extravillous trophoblast invasion
- MeSH terms
- Female, Fetal Growth Retardation, Fetus, Humans, Placenta, Pregnancy, Fetal Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
