Serum Oxytocin, Posttraumatic Coping and C-Reactive Protein in Motor Vehicle Accident Survivors by Gender
Abstract
Background: Previous studies indicate that oxytocin (OT) might play a major role in the prevention of posttraumatic stress disorder (PTSD) and that the effects of OT might differ by gender. This exploratory study aimed to clarify the relationships between the OT level and physical and psychosocial factors by gender in accident survivors. Methods: Two hundred and thirty-five accident survivors offered blood samples at baseline, 155 of whom participated in follow-up assessments 1 month later. Spearman's correlation coefficients were calculated between the serum OT levels and physical and psychosocial factors assessed at baseline by gender. Univariate and multivariate regression analyses were then used to examine the relationships between the serum OT levels and psychological variables by gender. Results: In men, the OT levels were negatively associated with C-reactive protein at baseline and did not predict any psychological variables at the 1-month follow-up. On the other hand, in women, the OT levels were positively associated with cooperativeness at baseline and predicted seeking social support, positive reappraisal, accepting responsibility and planful problem solving at the 1-month follow-up. The OT levels were not associated with PTSD, depression, and anxiety symptoms. Conclusions: The findings suggest that the role of OT in posttraumatic coping and inflammation differs by gender in accident survivors. Gender differences in the effects and mechanism of OT might be a key consideration when developing interventions using OT.
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Gender differences in the effects of oxytocin have been repeatedly reported.
“gender differences in the effects of oxytocin have been repeatedly reported [22, 23]”
Gender differences in oxytocin effects have been repeatedly described.
“Gender differences in oxytocin effects have been repeatedly described [22, 23]”
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
Posttraumatic Stress Disorder in the National Comorbidity Survey
Kessler, R. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240066012 · Cited by 10,379 · see citing works
A psychobiological model of temperament and character
Cloninger, C. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820240059008 · Cited by 5,458 · see citing works
Dynamics of a stressful encounter: Cognitive appraisal, coping, and encounter outcomes.
Folkman, S., Lazarus, R. S., Dunkel‐Schetter, C., DeLongis, A., & Gruen, R. J. (1986) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.50.5.992 · Cited by 4,893 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Baker, S. P., & O’Neill, B. (1976) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-197611000-00006 · Cited by 1,438 · see citing works
CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.
Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972 · see citing works
Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966 · see citing works
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
ASUKAI, N., KATO, H., KAWAMURA, N., KIM, Y., YAMAMOTO, K., KISHIMOTO, J., MIYAKE, Y., & NISHIZONO-MAHER, A. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200203000-00006 · Cited by 679 · see citing works
Self-citationObesity and C ‐reactive protein in various populations: a systematic review and meta‐analysis
Choi, J., Joseph, L., & Pilote, L. (2012) · Obesity Reviews · doi:10.1111/obr.12003 · Cited by 657 · see citing works
Grewen, K. M., Girdler, S. S., Amico, J., & Light, K. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170341.88395.47 · Cited by 513 · see citing works
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
北村, 貴., Saitoh, Y., Takashima, N., Murayama, A., Niibori, Y., Ageta, H., Sekiguchi, M., Sugiyama, H., & Inokuchi, K. (2009) · Cell · doi:10.1016/j.cell.2009.10.020 · Cited by 489 · see citing works
Feldman, R., Gordon, I., & Zagoory‐Sharon, O. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2010.01021.x · Cited by 486 · see citing works
Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk
Eraly, S. A., Nievergelt, C. M., Maihofer, A. X., Barkauskas, D. A., Biswas, N., Agorastos, A., O’Connor, D. T., & Baker, D. G. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4374 · Cited by 386 · see citing works
Screening for Psychological Distress in Japanese Cancer Patients
Kugaya, A., Akechi, T., Okuyama, T., Okamura, H., & Uchitomi, Y. (1998) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/28.5.333 · Cited by 367 · see citing works
Skrundz, M., Bolten, M., Nast, I., Hellhammer, D. H., & Meinlschmidt, G. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.74 · Cited by 349 · see citing works
Plasma oxytocin levels and anxiety in patients with major depression
Scantamburlo, G., Hansenne, M., Fuchs, S., Pitchot, W., Maréchal, P., Péqueux, C., Ansseau, M., & Legros, J. J. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.01.009 · Cited by 325 · see citing works
High doses of oxytocin cause sedation and low doses cause an anxiolytic-like effect in male rats
Uvnäs‐Moberg, K., Ahlenius, S., Hillegaart, V., & Alster, P. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90462-6 · Cited by 254 · see citing works
REVIEW: Oxytocin: Crossing the Bridge between Basic Science and Pharmacotherapy
Viéro, C., Shibuya, I., Kitamura, N., Verkhratsky, A., Fujihara, H., Katoh, A., Ueta, Y., Zingg, H. H., Chvátal, A., Syková, E., et al. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00185.x · Cited by 250 · see citing works
Physiological and Endocrine Effects of Social Contact
Uvnäs‐Moberg, K. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51917.x · Cited by 250 · see citing works
Weisman, O., Zagoory‐Sharon, O., Schneiderman, I., Gordon, I., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.011 · Cited by 170 · see citing works
Usefulness of a Japanese version of the Mini-Mental State Test in neurological patients
Mori (1985) · Cited by 155 · see citing works
Bonding after trauma: on the role of social support and the oxytocin system in traumatic stress
Olff, M. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.18597 · Cited by 131 · see citing works
RELIABILITY AND VALIDITY OF THE JAPANESE VERSION OF THE TEMPERAMENT AND CHARACTER INVENTORY
Kijima, N., Tanaka, E., Suzuki, N., Higuchi, H., & Kitamura, T. (2000) · Psychological Reports · doi:10.2466/pr0.2000.86.3.1050 · Cited by 126 · see citing works
When Two Become One: The Role of Oxytocin in Interpersonal Coordination and Cooperation
Arueti, M., Perach-Barzilay, N., Tsoory, M. M., Berger, B., Getter, N., & Shamay-Tsoory, S. G. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00400 · Cited by 67 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59 · see citing works
Szeto, A., Rossetti, M. A., Mendez, A. J., Noller, C. M., Herderick, E. E., Gonzales, J. A., Schneiderman, N., & McCabe, P. M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.009 · Cited by 57 · see citing works
Matsuoka, Y. (2011) · BioPsychoSocial Medicine · doi:10.1186/1751-0759-5-3 · Cited by 42 · see citing works
Self-citationMatsuoka, Y., Nishi, D., Nakajima, S., Yonemoto, N., Hashimoto, K., Noguchi, H., Homma, M., Otomo, Y., & Kim, Y. (2008) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-008-0438-6 · Cited by 34 · see citing works
Self-citationRole of Oxytocin in deceleration of early atherosclerotic inflammatory processes in adult male rats.
Ahmed, M. A., & Elosaily, G. M. (2011) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Nishi, D., Matsuoka, Y., Nakajima, S., Noguchi, H., Kim, Y., Kanba, S., & Schnyder, U. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2008.02.003 · Cited by 16 · see citing works
Self-citationSerum neuropeptide Y in accident survivors with depression or posttraumatic stress disorder
Nishi, D., Hashimoto, K., Noguchi, H., & Matsuoka, Y. (2014) · Neuroscience Research · doi:10.1016/j.neures.2014.03.009 · Cited by 14 · see citing works
Self-citationRELIABILITY AND VALIDITY OF THE JAPANESE VERSION OF THE TEMPERAMENT AND CHARACTER INVENTORY
Kijima, N. (2000) · Psychological Reports · doi:10.2466/pr0.86.3.1050-1058 · Cited by 10 · see citing works
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Cited by
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In the search for integrative biomarker of resilience to psychological stress
Walker, F. R., Pfingst, K., Carnevali, L., Sgoifo, A., & Nalivaiko, E. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.003 · Cited by 211 · see citing works
van Zuiden, M., Frijling, J. L., Nawijn, L., Koch, S. B. J., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Veltman, D. J., & Olff, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.012 · Cited by 134 · see citing works
The Associations Between Oxytocin and Trauma in Humans: A Systematic Review
Donadon, M. F., Martín‐Santos, R., & Osório, F. D. L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00154 · Cited by 119 · see citing works
Hypothalamus and Post-Traumatic Stress Disorder: A Review
Raise‐Abdullahi, P., Meamar, M., Vafaei, A. A., Alizadeh, M., Dadkhah, M., Shafia, S., Ghalandari-Shamami, M., Naderian, R., Samaei, A., & Rashidy‐Pour, A. (2023) · Brain Sciences · doi:10.3390/brainsci13071010 · Cited by 80 · see citing works
Swaab, D. F., & Bao, A. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64123-6.00023-0 · Cited by 56 · see citing works
Sack, M., Spieler, D., Wizelman, L., Epple, G., Stich, J., Zaba, M., & Schmidt, U. (2017) · BMC Medicine · doi:10.1186/s12916-017-0801-0 · Cited by 57 · see citing works
Düsing, R., Mattie Tops, A., Radtke, E. L., Kühl, J., & Quirin, M. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.01.012 · Cited by 46 · see citing works
Role of neuroinflammation and sex hormones in war-related PTSD.
Mendoza, C., Barreto, G., Avila-Rodriguez, M. F., & Echeverría, V. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.05.016 · Cited by 43 · see citing works
Female psychopharmacology matters! Towards a sex-specific psychopharmacology
Bolea-Alamanac, B. M., Bailey, S., Lovick, T. A., Scheele, D., & Valentino, R. J. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117747578 · Cited by 44 · see citing works
Decreased Plasma Oxytocin Levels in Patients With PTSD
Carmassi, C., Marazziti, D., Mucci, F., Vecchia, A. D., Barberi, F. M., Baroni, S., Giannaccini, G., Palego, L., Massimetti, G., & Dell’Osso, L. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.612338 · Cited by 36 · see citing works
Bina, R. W., & Langevin, J. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00300 · Cited by 35 · see citing works
Witteveen, A. B., Stramrood, C. A. I., Henrichs, J., Flanagan, J. C., van Pampus, M. G., & Olff, M. (2019) · Archives of Women s Mental Health · doi:10.1007/s00737-019-00994-0 · Cited by 29 · see citing works
Reijnen, A., Geuze, E., & Vermetten, E. H. G. J. M. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.06.010 · Cited by 29 · see citing works
Sbisa, A. M., Madden, K., Toben, C. G., McFARLANE, A. C., Dell, L., & Lawrence‐Wood, E. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105954 · Cited by 27 · see citing works
Engel, S., Klusmann, H., Laufer, S., Pfeifer, A.-C., Ditzen, B., van Zuiden, M., Knaevelsrud, C., & Schumacher, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.003 · Cited by 22 · see citing works
Sex matters: The impact of oxytocin on healthy conditions and psychiatric disorders
Marazziti, D., Carter, C. S., Carmassi, C., Vecchia, A. D., Mucci, F., Pagni, G., Carbone, M. G., Baroni, S., Giannaccini, G., Palego, L., et al. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100165 · Cited by 18 · see citing works
H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease
McCook, O., Denoix, N., Radermacher, P., Waller, C., & Merz, T. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10163484 · Cited by 16 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
Peripheral Biomarker Candidates of Posttraumatic Stress Disorder
Kang, H. J., Yoon, S. J., & Lyoo, I. K. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.3.186 · Cited by 14 · see citing works
Engel, S., van Zuiden, M., Frijling, J. L., Koch, S. B. J., Nawijn, L., Yildiz, R. L. W., Schumacher, S., Knaevelsrud, C., Bosch, J. A., Veltman, D. J., et al. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1761622 · Cited by 14 · see citing works
Kampka, N., Frommann, N., Henning, U., Schwark, R., Wölwer, W., Pietrowsky, R., & Luckhaus, C. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1955-4 · Cited by 9 · see citing works
Miwa, Y., Furuya, H., Yanai, R., Kasama, T., & Sanada, K. (2017) · Internal Medicine · doi:10.2169/internalmedicine.9191-17 · Cited by 3 · see citing works
Miwa, Y., Furuya, H., Yanai, R., Kasama, T., & Sanada, K. (2018) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2018.17021
- Authors
- Nishi, D., Hashimoto, K., Noguchi, H., Kim, Y., & Matsuoka, Y.
- Affiliations
- National Disaster Medical Center (JP)
- Chiba University (JP)
- National Center of Neurology and Psychiatry (JP)
- Venue
- Neuropsychobiology
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 71
- Issue
- 4
- Pages
- 196-201
- ISSN
- 0302-282X (ISSN-L)
- 1423-0224
- OpenAlex
- W2220662798
- Cited by
- 23
- References
- 36
- Citations by year
- 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 1
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Astellas Foundation for Research on Metabolic Disorders
- National Center of Neurology and Psychiatry
- Pfizer Japan
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- oxytocin, motor vehicle accidents, post-traumatic stress disorder, C-reactive protein, inflammation, gender differences, social support seeking, positive reappraisal, problem solving, depression, anxiety, accident survivors
- MeSH terms
- Accidents, Traffic, Adaptation, Psychological, Adult, C-Reactive Protein, Female, Humans, Inflammation, Male, Middle Aged, Oxytocin, Sex Factors, Stress Disorders, Post-Traumatic, Survivors
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