Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk
Open accessAbstract
IMPORTANCE: Posttraumatic stress disorder (PTSD) has been associated in cross-sectional studies with peripheral inflammation. It is not known whether this observed association is the result of PTSD predisposing to inflammation (as sometimes postulated) or to inflammation predisposing to PTSD. OBJECTIVE: To determine whether plasma concentration of the inflammatory marker C-reactive protein (CRP) helps predict PTSD symptoms. DESIGN, SETTING, AND PARTICIPANTS: The Marine Resiliency Study, a prospective study of approximately 2600 war zone-deployed Marines, evaluated PTSD symptoms and various physiological and psychological parameters before deployment and at approximately 3 and 6 months following a 7-month deployment. Participants were recruited from 4 all-male infantry battalions imminently deploying to a war zone. Participation was requested of 2978 individuals; 2610 people (87.6%) consented and 2555 (85.8%) were included in the present analysis. Postdeployment data on combat-related trauma were included for 2208 participants (86.4% of the 2555 included) and on PTSD symptoms at 3 and 6 months after deployment for 1861 (72.8%) and 1617 (63.3%) participants, respectively. MAIN OUTCOMES AND MEASURES: Severity of PTSD symptoms 3 months after deployment assessed by the Clinician-Administered PTSD Scale (CAPS). RESULTS: We determined the effects of baseline plasma CRP concentration on postdeployment CAPS using zero-inflated negative binomial regression (ZINBR), a procedure designed for distributions, such as CAPS in this study, that have an excess of zeroes in addition to being positively skewed. Adjusting for the baseline CAPS score, trauma exposure, and other relevant covariates, we found baseline plasma CRP concentration to be a highly significant overall predictor of postdeployment CAPS scores (P = .002): each 10-fold increment in CRP concentration was associated with an odds ratio of nonzero outcome (presence vs absence of any PTSD symptoms) of 1.51 (95% CI, 1.15-1.97; P = .003) and a fold increase in outcome with a nonzero value (extent of symptoms when present) of 1.06 (95% CI, 0.99-1.14; P = .09). CONCLUSIONS: AND RELEVANCE A marker of peripheral inflammation, plasma CRP may be prospectively associated with PTSD symptom emergence, suggesting that inflammation may predispose to PTSD.
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Higher pre-deployment concentrations of CRP increase post-deployment risk for development of PTSD.
“Indeed, higher pre-deployment concentrations of CRP increase postdeployment risk for development of PTSD (Eraly et al, 2014).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Eraly et al, 2014
The Abstract Results report that higher pre-deployment CRP predicted greater odds of any post-deployment PTSD symptoms. The Comment describes this as a prospective association and a possible marker of vulnerability, not proof that CRP causes PTSD to develop; the measured outcome was symptoms rather than a PTSD diagnosis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredProspective studies have begun to show that higher levels of inflammation prior to trauma exposure increase risk for subsequent development of PTSD following trauma exposure.
“Although no data as yet prospectively demonstrate that chronic PTSD results in augmented inflammation, prospective studies have begun to show that higher levels of inflammation prior to trauma exposure increases risk for subsequent development of PTSD following trauma exposure (Breen et al, 2015;Eraly et al, 2014;Glatt et al, 2013;Tylee et al, 2015).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Eraly et al, 2014
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The development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
The Metabolic Syndrome and Cardiovascular Risk
Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., & Eisenberg, M. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.034 · Cited by 3,009 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
Macrophages, inflammation, and insulin resistance
Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635 · see citing works
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365 · see citing works
Post-Traumatic Stress Disorder
Yehuda, R. (2002) · New England Journal of Medicine · doi:10.1056/nejmra012941 · Cited by 1,134 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
Yanbaeva, D. G., Dentener, M. A., Creutzberg, E. C., Wesseling, G., & Wouters, E. F. �. (2007) · CHEST Journal · doi:10.1378/chest.06-2179 · Cited by 1,022 · see citing works
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
Glass, C. K., & Olefsky, J. M. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.001 · Cited by 942 · see citing works
Seal (2007) · doi:10.1001/archinte.167.5.476 · Cited by 936 · see citing works
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.015 · Cited by 756 · see citing works
Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys, M. B., Hirschfield, G. M., Tennent, G. A., Ruth Gallimore, J., Kahan, M. C., Bellotti, V., Hawkins, P. N., Myers, R. M., Smith, M. D., Polara, A., et al. (2006) · Nature · doi:10.1038/nature04672 · Cited by 672 · see citing works
Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk
Grundy, S. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.080 · Cited by 627 · see citing works
Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596 · see citing works
Gimeno, D., Kivimäki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., Kumari, M., Lowe, G. D. O., Rumley, A., Marmot, M. G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291708003723 · Cited by 561 · see citing works
Santiago, P. N., Ursano, R. J., Gray, C. L., Pynoos, R. S., Spiegel, D., Lewis-Fernandez, R., Friedman, M. J., & Fullerton, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059236 · Cited by 536 · see citing works
Is depression an inflammatory disorder?
Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works
Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals
Wium-Andersen, M. K., Ørsted, D. D., Nielsen, S. F., & Nordestgaard, B. G. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.102 · Cited by 489 · see citing works
von Känel, R., Hepp, U., Kraemer, B., Traber, R., Keel, M., Mica, L., & Schnyder, U. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.06.009 · Cited by 408 · see citing works
Maes, M., Lin, A.-H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., & Bosmans, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00131-0 · Cited by 387 · see citing works
Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works
Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder
Hoge, E. A., Brandstetter, K., Moshier, S., Pollack, M. H., Wong, K. K., & Simon, N. M. (2009) · Depression and Anxiety · doi:10.1002/da.20564 · Cited by 343 · see citing works
Mood and cognitive side effects of interferon-alpha therapy.
Valentine, A. D., Meyers, C. A., Kling, M. A., Richelson, E., & Hauser, P. (1998) · PubMed · Cited by 312 · see citing works
Acute inflammation and negative mood: mediation by cytokine activation
Wright, C. E., Strike, P. C., Brydon, L., & Steptoe, A. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.10.003 · Cited by 287 · see citing works
Heppner, P. S., Crawford, E. F., Haji, U. A., Afari, N., Hauger, R. L., Dashevsky, B. A., Horn, P. S., Nunnink, S. E., & Baker, D. G. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-1 · Cited by 274 · see citing works
Self-citationPTSD is associated with an excess of inflammatory immune activities
Gill, J. M., Saligan, L., Woods, S., & Page, G. (2009) · Perspectives in Psychiatric Care · doi:10.1111/j.1744-6163.2009.00229.x · Cited by 271 · see citing works
Cumulative Depression Episodes Predict Later C-Reactive Protein Levels: A Prospective Analysis
Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.023 · Cited by 265 · see citing works
Post-traumatic stress disorder and smoking: A systematic review
Fu, S. S., McFall, M., Saxon, A. J., Beckham, J. C., Carmody, T. P., Baker, D. G., & Joseph, A. M. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701488418 · Cited by 260 · see citing works
Self-citationSchnyder, U., Moergeli, H., Klaghofer, R., & Buddeberg, C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.594 · Cited by 255 · see citing works
Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
Wersching, H., Duning, T., Lohmann, H., Mohammadi, S., Stehling, C., Fobker, M., Conty, M., Minnerup, J., Ringelstein, E. B., Berger, K., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d7b45b · Cited by 235 · see citing works
Spitzer, C., Barnow, S., Völzke, H., Wallaschofski, H., John, U., Freyberger, H. J., Löwe, B., & Grabe, H. J. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.06.002 · Cited by 205 · see citing works
Alkerwi, A., Boutsen, M., Vaillant, M., Barré, J., Lair, M., Albert, A., Guillaume, M., & Dramaix, M. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.10.036 · Cited by 198 · see citing works
Schäfer, I., & Najavits, L. M. (2007) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282f0ffd9 · Cited by 194 · see citing works
Duivis, H. E., de Jonge, P., Penninx, B. W., Na, B. Y., Cohen, B. E., & Whooley, M. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10081163 · Cited by 191 · see citing works
Metabolic syndrome and cardiovascular risk
Alshehri, A. (2010) · Journal of Family and Community Medicine · doi:10.4103/1319-1683.71987 · Cited by 184 · see citing works
Pitman, R. K., Gilbertson, M. W., Gurvits, T. V., May, F. S., Lasko, N. B., Metzger, L. J., Shenton, M. E., Yehuda, R., Orr, S. P., & for the Harvard/VA PTSD Twin Study Investigators (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.019 · Cited by 178 · see citing works
Frodl, T., Carballedo, A., Hughes, M. M., Saleh, K., Fagan, A., Skokauskas, N., McLoughlin, D. M., Meaney, J., O'Keane, V, & Connor, T. J. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.14 · Cited by 176 · see citing works
Biomarkers of PTSD: Neuropeptides and immune signaling
Baker, D. G., Nievergelt, C. M., & O’Connor, D. T. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.027 · Cited by 172 · see citing works
Self-citationModerate alcohol consumption and lower levels of inflammatory markers in US men and women
Pai, J. K., Hankinson, S. E., Thadhani, R., Rifai, N., Pischon, T., & Rimm, E. B. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.06.037 · Cited by 149 · see citing works
The Link Between Post-traumatic Stress Disorder and Physical Comorbidities: A Systematic Review
Qureshi, S. U., Pyne, J. M., Magruder, K. M., Schulz, P. E., & Kunik, M. E. (2009) · Psychiatric Quarterly · doi:10.1007/s11126-009-9096-4 · Cited by 141 · see citing works
Risk of Diabetes in U.S. Military Service Members in Relation to Combat Deployment and Mental Health
Boyko, E. J., Jacobson, I. G., Smith, B., Ryan, M. A. K., Hooper, T. I., Amoroso, P. J., Gackstetter, G. D., Barrett-Connor, E. L., Smith, T. C., & for the Millennium Cohort Study Team (2010) · Diabetes Care · doi:10.2337/dc10-0296 · Cited by 137 · see citing works
C-reactive protein is related to memory and medial temporal brain volume in older adults
Bettcher, B. M., Wilheim, R., Rigby, T., Green, R., Miller, J. W., Racine, C. A., Yaffe, K. S., Miller, B. L., & Kramer, J. H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.07.240 · Cited by 136 · see citing works
Depression From Interferon Therapy in Patients With Hepatitis C
Miyaoka, H., Otsubo, T., Kamijima, K., Ishii, M., ONUKI, M., & Mitamura, K. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.7.1120 · Cited by 135 · see citing works
Adams, R. E., Boscarino, J. A., & Galea, S. (2006) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990500479522 · Cited by 131 · see citing works
Baker, D. G., Heppner, P. S., Afari, N., Nunnink, S. E., Kilmer, M. T., Simmons, A. N., Harder, L. H., & Bosse, B. (2009) · Military Medicine · doi:10.7205/milmed-d-03-3808 · Cited by 121 · see citing works
Self-citationPietrzak, R. H., Goldstein, M. B., Malley, J. C., Johnson, D. C., & Southwick, S. M. (2009) · Depression and Anxiety · doi:10.1002/da.20574 · Cited by 121 · see citing works
Police trauma and cardiovascular disease: association between PTSD symptoms and metabolic syndrome.
Violanti, J. M., Fekedulegn, D. B., Hartley, T. A., Andrew, M. E., Charles, L. E., Mnatsakanova, A., & Burchfiel, C. M. (2006) · PubMed · Cited by 120 · see citing works
Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome
Rasmusson, A. M., Schnurr, P. P., Żukowska, Z., Scioli, E. R., & Forman, D. E. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009334 · Cited by 119 · see citing works
von Känel, R., Begré, S., Abbas, C. C., Saner, H. E., Gander, M., & Schmid, J. (2009) · NeuroImmunoModulation · doi:10.1159/000243084 · Cited by 115 · see citing works
Study on serum cytokine levels in posttraumatic stress disorder patients
Guo, M., Liu, T., Guo, J.-C., Jiang, X.-L., Chen, F., & Gao, Y.-S. (2012) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(12)60048-0 · Cited by 113 · see citing works
Powell, N. D., Bailey, M. T., Mays, J. W., Stiner-Jones, L. M., Hanke, M. L., Padgett, D. A., & Sheridan, J. F. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.010 · Cited by 112 · see citing works
Serum high sensitivity C-reactive protein and cognitive function in elderly women
Komulainen, P., Lakka, T. A., Kivipelto, M., Hassinen, M., Penttila, I. M., Helkala, E.-L., Gylling, H. K., Nissinen, A. M., & Rauramaa, R. (2007) · Age and Ageing · doi:10.1093/ageing/afm051 · Cited by 109 · see citing works
Deverts, D. J., Cohen, S., DiLillo, V. G., Lewis, C. E., Kiefe, C. I., Whooley, M. A., & Matthews, K. A. (2010) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181ec4b98 · Cited by 104 · see citing works
Serum C-reactive protein as a marker for wellness assessment.
Kao, P. C., Shiesh, S. C., & Wu, T. J. (2006) · PubMed · Cited by 101 · see citing works
Self-reported diabetes and posttraumatic stress disorder among adults in the community
Goodwin, R. D., & Davidson, J. R. T. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.07.013 · Cited by 100 · see citing works
Chida, Y., Sudo, N., Sonoda, J., Hiramoto, T., & Kubo, C. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200607-898oc · Cited by 95 · see citing works
Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
Cavalieri, M., Ropele, S., Petrovic, K., Pluta-Fuerst, A., Homayoon, N., Enzinger, C., Grazer, A., Katschnig, P., Schwingenschuh, P., Berghold, A., et al. (2010) · Diabetes Care · doi:10.2337/dc10-0851 · Cited by 92 · see citing works
Depressive symptoms and C-reactive protein: The Cardiovascular Risk in Young Finns Study
Elovainio, M. J., Keltikangas‐Järvinen, L., Pulkki-Råbäck, L., Mika Kivimaki, B., Puttonen, S., Viikari, L. A., Räsänen, L., Mansikkaniemi, K., Viikari, J. S. A., & Raitakari, O. T. (2006) · Psychological Medicine · doi:10.1017/s0033291706007574 · Cited by 92 · see citing works
Baker, D., Nash, W. N. C., Litz, B. T., Geyer, M., Risbrough, V. B., & Nievergelt, C. M. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110134 · Cited by 90 · see citing works
Self-citationAssociation Between Depression and Inflammation-Differences by Race and Sex
Morris, A. A., Zhao, L., Ahmed, Y., Stoyanova, N., Staercke, C. D., Hooper, W. C., Gibbons, G. H., Din‐Dzietham, R., Quyyumi, A. A., & Vaccarino, V. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318222379c · Cited by 89 · see citing works
Interleukin-6 and Memory Functions of Encoding and Recall in Healthy and Depressed Elderly Adults
Elderkin‐Thompson, V., Irwin, M. R., Hellemann, G., & Kumar, A. (2012) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31825d08d6 · Cited by 86 · see citing works
Agyemang, C. O., Goosen, S., Anujuo, K. O., & Ogedegbe, G. G. (2011) · European Journal of Public Health · doi:10.1093/eurpub/ckr138 · Cited by 73 · see citing works
Early life stress inhibits expression of a novel innate immune pathway in the developing hippocampus
Wei, L., Simen, A., Mane, S., & Kaffman, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.239 · Cited by 71 · see citing works
Shen, J., & Ordovás, J. M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2008.117754 · Cited by 69 · see citing works
Association of Posttraumatic Stress Disorder With Increased Prevalence of Metabolic Syndrome
Jin, H., Lanouette, N. M., Mudaliar, S. R. D., Henry, R. R., Folsom, D. P., Khandrika, S., Glorioso, D., & Jeste, D. V. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181a45ed0 · Cited by 67 · see citing works
Metabolic and Biochemical Effects of Low‐to‐Moderate Alcohol Consumption
Whitfield, J. B., Heath, A. C., Madden, P. A. F., Pergadia, M. L., Montgomery, G. W., & Martin, N. G. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12015 · Cited by 61 · see citing works
(2006) · PubMed · Cited by 60 · see citing works
Repeated Assessments of Endocrine- and Immune-Related Changes in Posttraumatic Stress Disorder
Vidović, A., Gotovac, K., Vilibić, M., Sabioncello, A., Jovanović, T., Rabatić, S., Folnegović-Šmalć, V., & Dekaris, D. (2011) · Neuroimmunomodulation · doi:10.1159/000322869 · Cited by 56 · see citing works
The Role of C-Reactive Protein in Mood Disorders
Berardis, D. D., Campanella, D., Gambi, F., Rovere, R. L., Carano, A., Conti, C. M., Silvestrini, C., Serroni, N., Piersanti, D., Giuseppe, B. D., et al. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200601900402 · Cited by 52 · see citing works
Effects of lifestyle interventions on inflammatory markers in the metabolic syndrome
Beavers, K. M. (2010) · Frontiers in Bioscience-Scholar · doi:10.2741/s142 · Cited by 44 · see citing works
Deverts, D. J., Cohen, S., Kalra, P., & Matthews, K. A. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.07.017 · Cited by 44 · see citing works
Aurer, A., Aurer-Kozelj, J., Stavljenić-Rukavina, A., Kalenić, S., Ivić‐Kardum, M., & Haban, V. (1999) · PubMed · Cited by 33 · see citing works
Lewis W. Marshall Jr, M., Brenda L. Marshall, E., & Glenn Valladares, M. (2010) · American Journal of Disaster Medicine · doi:10.5055/ajdm.2010.0013 · Cited by 31 · see citing works
Heppner, P. S., Lohr, J. B., Kash, T. P., Jin, H., Wang, H., & Baker, D. G. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.05.005 · Cited by 29 · see citing works
Self-citationForbes, H. J., Jones, N., Woodhead, C., Greenberg, N. L., Harrison, K., White, S., Wessely, S. C., & Fear, N. T. (2012) · BMC Psychiatry · doi:10.1186/1471-244x-12-178 · Cited by 25 · see citing works
Posttraumatic stress and immune dissonance
Jiang, J. (2008) · Chinese Journal of Traumatology · doi:10.1016/s1008-1275(08)60044-9 · Cited by 15 · see citing works
Health surveillance of deployed military personnel occasionally leads to unexpected findings
McFARLANE, A. C. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-126 · Cited by 1 · see citing works
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Yehuda, R., Hoge, C. W., McFarlane, A. C., Vermetten, E., Lanius, R. A., Nievergelt, C. M., Hobfoll, S. E., Koenen, K. C., Neylan, T. C., & Hyman, S. E. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.57 · Cited by 870 · see citing works
Self-citationInflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond
Michopoulos, V., Powers, A., Gillespie, C. F., Ressler, K. J., & Jovanovic, T. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.146 · Cited by 786 · see citing works
Post-Traumatic Stress Disorder
Shalev, A. Y., Liberzon, I., & Marmar, C. R. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1612499 · Cited by 799 · see citing works
The resilience framework as a strategy to combat stress-related disorders
Kalisch, R., Baker, D. G., Basten, U., Boks, M. P., Bonanno, G. A., Brummelman, E., Chmitorz, A., Fernàndez, G., Fiebach, C. J., Galatzer-Levy, I., et al. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0200-8 · Cited by 782 · see citing works
Self-citationImaging the Role of Inflammation in Mood and Anxiety-related Disorders
Felger, J. C. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666171123201142 · Cited by 432 · see citing works
Inflammation and post‐traumatic stress disorder
Hori, H., & Kim, Y. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12820 · Cited by 416 · see citing works
Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
Danese, A., & J Lewis, S. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.198 · Cited by 393 · see citing works
Post-traumatic stress disorder and cardiovascular disease
Edmondson, D. E., & von Känel, R. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30377-7 · Cited by 346 · see citing works
Hidden wounds? inflammatory links between childhood trauma and psychopathology
Danese, A., & Baldwin, J. R. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044208 · Cited by 286 · see citing works
Evolution, human-microbe interactions, and life history plasticity
Rook, G., Bäckhed, F., Levin, B. R., McFall-Ngai, M. J., & McLean, A. R. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30566-4 · Cited by 246 · see citing works
Rosenbaum, S., Stubbs, B., Ward, P. B., Steel, Z., Lederman, O., & Vancampfort, D. (2015) · Metabolism · doi:10.1016/j.metabol.2015.04.009 · Cited by 246 · see citing works
Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD
Miller, M. W., Lin, A. P., Wolf, E. J., & Miller, D. R. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000167 · Cited by 237 · see citing works
Reber, S. O., Siebler, P. H., Donner, N. C., Morton, J. T., Smith, D. G., Kopelman, J. M., Lowe, K. R., Wheeler, K. J., Fox, J. H., Hassell, J. E., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600324113 · Cited by 233 · see citing works
Behl, T., Rana, T., Alotaibi, G., Shamsuzzaman, M., Naqvi, M., Sehgal, A., Singh, S., Sharma, N., Almoshari, Y., Abdellatif, A. A. H., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112545 · Cited by 230 · see citing works
Cytokines, Oxidative Stress and Cellular Markers of Inflammation in Schizophrenia
Upthegrove, R., & Khandaker, G. M. (2019) · Current topics in behavioral neurosciences · doi:10.1007/7854_2018_88 · Cited by 230 · see citing works
Understanding resilience: New approaches for preventing and treating PTSD
Horn, S. R. G.-V., Charney, D. S., & Feder, A. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.002 · Cited by 223 · see citing works
Treatment of Posttraumatic Stress Disorder: A State-of-the-art Review
Burback, L., Brémault‐Phillips, S., Nijdam, M. J., McFARLANE, A. C., & Vermetten, E. H. G. J. M. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230428091433 · Cited by 232 · see citing works
Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress
Lindqvist, D., Wolkowitz, O. M., Mellon, S., Yehuda, R., Flory, J. D., Henn-Haase, C., Bierer, L. M., Abu-Amara, D., Coy, M., Neylan, T. C., et al. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.06.003 · Cited by 213 · see citing works
The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study
Hemmings, S. M. J., Malan-Müller, S., van den Heuvel, L. L., Demmitt, B. A., Stanislawski, M. A., Smith, D. G., Bohr, A. D., Stamper, C. E., Hyde, E. R., Morton, J. T., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000512 · Cited by 208 · see citing works
Michopoulos, V., Norrholm, S. D., & Jovanovic, T. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.005 · Cited by 206 · see citing works
Michopoulos, V., Rothbaum, A. O., Jovanovic, T., Almli, L. M., Bradley, B., Rothbaum, B. O., Gillespie, C. F., & Ressler, K. J. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020263 · Cited by 203 · see citing works
Immunopsychiatry: important facts
Khandaker, G. M., Dantzer, R., & Jones, P. B. (2017) · Psychological Medicine · doi:10.1017/s0033291717000745 · Cited by 200 · see citing works
Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder
Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.007 · Cited by 184 · see citing works
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein, M. B., Chen, C., Ursano, R. J., Cai, T., Gelernter, J. E., Heeringa, S. G., Jain, S., Jensen, K. P., Maihofer, A. X., Mitchell, C. M., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0350 · Cited by 182 · see citing works
Self-citationGene networks specific for innate immunity define post-traumatic stress disorder
Breen, M. S., Maihofer, A. X., Glatt, S. J., Tylee, D. S., Chandler, S. D., Tsuang, M. T., Risbrough, V. B., Baker, D. G., O'Connor, D. T., Nievergelt, C. M., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.9 · Cited by 180 · see citing works
Self-citationThe role of the immune system in posttraumatic stress disorder
Katrinli, Ş., Oliveira, N. C. D. S., Felger, J. C., Michopoulos, V., & Smith, A. K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02094-7 · Cited by 177 · see citing works
Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders
Furtado, M., & Katzman, M. A. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.05.036 · Cited by 174 · see citing works
The microbiota, immunoregulation, and mental health: implications for public health
Lowry, C. A., Smith, D. G., Siebler, P. H., Schmidt, D., Stamper, C. E., Hassell, J. E., Yamashita, P. S., Fox, J. H., Reber, S. O., Brenner, L. A., et al. (2016) · Current Environmental Health Reports · doi:10.1007/s40572-016-0100-5 · Cited by 172 · see citing works
The complex neurobiology of resilient functioning after childhood maltreatment
Ioannidis, K., Askelund, A. D., Kievit, R., & van Harmelen, A. (2020) · BMC Medicine · doi:10.1186/s12916-020-1490-7 · Cited by 163 · see citing works
Posttraumatic stress disorder: from diagnosis to prevention
Miao, X.-R., Chen, Q.-B., Wei, K., Tao, K.-M., & Lu, Z.-J. (2018) · Military Medical Research · doi:10.1186/s40779-018-0179-0 · Cited by 161 · see citing works
MRI findings in posttraumatic stress disorder
Kunimatsu, A., Yasaka, K., Akai, H., Kunimatsu, N., & Abe, O. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26929 · Cited by 163 · see citing works
Therapeutic Implications of Brain–Immune Interactions: Treatment in Translation
Miller, A. H., Haroon, E., & Felger, J. C. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.167 · Cited by 152 · see citing works
Posttraumatic stress disorder: A metabolic disorder in disguise?
Michopoulos, V., Vester, A., & Neigh, G. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.05.038 · Cited by 152 · see citing works
Understanding Resilience and Preventing and Treating PTSD
Horn, S. R. G.-V., & Feder, A. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000194 · Cited by 150 · see citing works
Recent Genetics and Epigenetics Approaches to PTSD
Daskalakis, N. P., Rijal, C. M., King, C. D., Huckins, L. M., & Ressler, K. J. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0898-7 · Cited by 146 · see citing works
Neuroinflammation and cognition across psychiatric conditions
Fourrier, C., Singhal, G., & Baune, B. T. (2019) · CNS Spectrums · doi:10.1017/s1092852918001499 · Cited by 145 · see citing works
Minassian, A., Maihofer, A. X., Baker, D. G., Nievergelt, C. M., Geyer, M. A., & Risbrough, V. B. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0922 · Cited by 146 · see citing works
Self-citationPosttraumatic Stress Disorder and Cardiovascular Disease
O’Donnell, C. J., Longacre, L. S., Cohen, B. E., Fayad, Z. A., Gillespie, C. F., Liberzon, I., Pathak, G. A., Polimanti, R. A., Risbrough, V. B., Ursano, R. J., et al. (2021) · JAMA Cardiology · doi:10.1001/jamacardio.2021.2530 · Cited by 142 · see citing works
Hakamata, Y., Suzuki, Y., Kobashikawa, H., & Hori, H. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100994 · Cited by 141 · see citing works
Koenen, K. C., Sumner, J. A., Gilsanz, P., Glymour, M. M., Ratanatharathorn, A., Rimm, E. B., Roberts, A. L., Winning, A., & Kubzansky, L. D. (2017) · Psychological Medicine · doi:10.1017/s0033291716002294 · Cited by 136 · see citing works
Posttraumatic Stress Disorder and Inflammation: Untangling Issues of Bidirectionality
Sumner, J. A., Nishimi, K. M., Koenen, K. C., Roberts, A. L., & Kubzansky, L. D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.11.005 · Cited by 131 · see citing works
Ten questions concerning the built environment and mental health
Hoisington, A. J., Stearns‐Yoder, K. A., Schuldt, S., Beemer, C. J., Maestre, J. P., Kinney, K. A., Postolache, T. T., Lowry, C. A., & Brenner, L. A. (2019) · Building and Environment · doi:10.1016/j.buildenv.2019.03.036 · Cited by 135 · see citing works
Co-morbidity of PTSD and immune system dysfunction: opportunities for treatment
Neigh, G. N., & Ali, F. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.07.011 · Cited by 122 · see citing works
Posttraumatic stress disorder: does the gut microbiome hold the key?
Leclercq, S., Forsythe, P., & Bienenstock, J. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716635535 · Cited by 121 · see citing works
Peruzzolo, T. L., Pinto, J. V., Roza, T. H., Shintani, A. O., Anzolin, A. P., Gnielka, V., Kohmann, A. M., Marin, A. S., Lorenzon, V. R., Brunoni, A. R., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01564-0 · Cited by 125 · see citing works
Neurobiology and systems biology of stress resilience
Kalisch, R., Russo, S. J., & Müller, M. B. (2024) · Physiological Reviews · doi:10.1152/physrev.00042.2023 · Cited by 137 · see citing works
Increased pro-inflammatory milieu in combat related PTSD – A new cohort replication study
Lindqvist, D., Dhabhar, F. S., Mellon, S. H., Yehuda, R., Grenon, S. M., Flory, J. D., Bierer, L. M., Abu-Amara, D., Coy, M., Makotkine, I., et al. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.09.012 · Cited by 114 · see citing works
Mehta, N. D., Haroon, E., Xu, X., Woolwine, B. J., Li, Z., & Felger, J. C. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.026 · Cited by 116 · see citing works
Inflammatory Biomarkers and Risk of Psychiatric Disorders
Zeng, Y., Chourpiliadis, C. P., Hammar, N., Seitz, C., Valdimarsdóttir, U. A., Fang, F., Song, H., & Wei, D. (2024) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2024.2185 · Cited by 118 · see citing works
Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice
Li, S., Liao, Y., Dong, Y., Li, X., Li, J., Cheng, Y., Cheng, J., & Yuan, Z. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02069-9 · Cited by 112 · see citing works
Schultebraucks, K., Qian, M., Amara, D. A., Dean, K. R., LASKA, E. M., Siegel, C., Gautam, A., Guffanti, G., Hammamieh, R., Misganaw, B., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0789-2 · Cited by 110 · see citing works
Bhatt, S., Hillmer, A. T., Girgenti, M. J., Rusowicz, A., Kapinos, M., Nabulsi, N., Huang, Y. H., Matuskey, D., Angarita, G. A., Esterlis, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15930-5 · Cited by 106 · see citing works
Daskalakis, N. P., Cohen, H., Nievergelt, C. M., Baker, D. G., Buxbaum, J. D., Russo, S. J., & Yehuda, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.024 · Cited by 105 · see citing works
Self-citationType 2 Diabetes Among People With Posttraumatic Stress Disorder: Systematic Review and Meta-Analysis
Vancampfort, D., Rosenbaum, S., Ward, P. B., Steel, Z., Lederman, O., Lamwaka, A. V., Richards, J. W., & Stubbs, B. (2016) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000297 · Cited by 97 · see citing works
Neuroinflammation in Post-Traumatic Stress Disorder
Lee, D.-H., Lee, J.-Y., Hong, D.-Y., Lee, E.-C., Park, S.-W., Lee, M. R., & Oh, J. S. (2022) · Biomedicines · doi:10.3390/biomedicines10050953 · Cited by 97 · see citing works
Rathbone, A. T. L., Tharmaradinam, S., Jiang, S., Rathbone, M. P., & Kumbhare, D. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.02.009 · Cited by 95 · see citing works
Psychoneuroimmunology—developments in stress research
Straub, R. H., & Cutolo, M. (2017) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-017-0574-2 · Cited by 94 · see citing works
Frank, M. G., Fonken, L. K., Dolzani, S. D., Annis, J. L., Siebler, P. H., Schmidt, D., Watkins, L. R., Maier, S. F., & Lowry, C. A. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.020 · Cited by 91 · see citing works
The old friends hypothesis: evolution, immunoregulation and essential microbial inputs
Rook, G. A. W. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2023.1220481 · Cited by 93 · see citing works
O’Donovan, A., Chao, L. L., Paulson, J., Samuelson, K. W., Shigenaga, J. K., Grunfeld, C., Weiner, M. W., & Neylan, T. C. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.11.010 · Cited by 86 · see citing works
Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity
Wolf, E. J., Bovin, M. J., Green, J. D., Mitchell, K. S., Stoop, T. B., Barretto, K., Jackson, C. E., Lee, L. O., Fang, S. C., Trachtenberg, F. L., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716000817 · Cited by 85 · see citing works
Posttraumatic Stress Disorder: An Immunological Disorder?
Wang, Z., Caughron, B., & Young, M. R. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00222 · Cited by 83 · see citing works
Resilience in the age of COVID-19
Kaye‐Kauderer, H., Feingold, J. H., Feder, A., Southwick, S. M., & Charney, D. S. (2021) · BJPsych Advances · doi:10.1192/bja.2021.5 · Cited by 84 · see citing works
Understanding exosomes: Part 2—Emerging leaders in regenerative medicine
Miron, R. J., Estrin, N. E., Sculean, A., & Zhang, Y. (2024) · Periodontology 2000 · doi:10.1111/prd.12561 · Cited by 83 · see citing works
O’Donovan, A., Ahmadian, A. J., Neylan, T. C., Pacult, M. A., Edmondson, D. E., & Cohen, B. E. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.10.014 · Cited by 82 · see citing works
The Need to Take a Staging Approach to the Biological Mechanisms of PTSD and its Treatment
McFARLANE, A. C., Lawrence-Wood, E., Hooff, M. V., Malhi, G. S., & Yehuda, R. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0761-2 · Cited by 82 · see citing works
Miller, M. W., Maniates, H., Wolf, E. J., Logue, M. W., Schichman, S. A., Stone, A., Milberg, W., & McGlinchey, R. E. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.08.022 · Cited by 78 · see citing works
Risbrough, V. B., Vaughn, M. N., & Friend, S. F. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.012 · Cited by 75 · see citing works
Old Friends, immunoregulation, and stress resilience
Langgartner, D., Lowry, C. A., & Reber, S. O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2228-7 · Cited by 73 · see citing works
Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women
Mehta, N. D., Stevens, J. S., Li, Z., Gillespie, C. F., Fani, N., Michopoulos, V., & Felger, J. C. (2020) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz100 · Cited by 70 · see citing works
Brenner, L. A., Forster, J. E., Stearns‐Yoder, K. A., Stamper, C. E., Hoisington, A. J., Brostow, D. P., Mealer, M. L., Wortzel, H. S., Postolache, T. T., & Lowry, C. A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.01015 · Cited by 69 · see citing works
Posttraumatic stress disorder onset and inflammatory and endothelial function biomarkers in women
Sumner, J. A., Chen, Q., Roberts, A. L., Winning, A., Rimm, E. B., Gilsanz, P., Glymour, M. M., Tworoger, S. S., Koenen, K. C., & Kubzansky, L. D. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.11.013 · Cited by 68 · see citing works
Finnell, J. E., & Wood, S. K. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.04.001 · Cited by 68 · see citing works
Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models
Deslauriers, J., Powell, S. B., & Risbrough, V. B. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.01.005 · Cited by 67 · see citing works
Bourla, A., Mouchabac, S., El‐Hage, W., & Ferreri, F. (2018) · European Journal of Psychotraumatology · doi:10.1080/20008198.2018.1424448 · Cited by 72 · see citing works
Rosen, R. L., Levy‐Carrick, N. C., Reibman, J., Xu, N., Shao, Y., Liu, M., Ferri, L., Kazeros, A., Caplan‐Shaw, C., Pradhan, D. R., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.01.007 · Cited by 64 · see citing works
Michopoulos, V., Beurel, E., Gould, F., Dhabhar, F. S., Schultebraucks, K., Galatzer‐Levy, I. R., ROTHBAUM, B. O., Ressler, K. J., & Nemeroff, C. B. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010039 · Cited by 65 · see citing works
Tylee, D. S., Chandler, S. D., Nievergelt, C. M., Liu, X., Pazol, J., Woelk, C. H., Lohr, J. B., Kremen, W. S., Baker, D. G., Glatt, S. J., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.024 · Cited by 65 · see citing works
Self-citationLin, J. E., Neylan, T. C., Epel, E., & O’Donovan, A. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.015 · Cited by 63 · see citing works
PTSD, a Disorder with an Immunological Component
Wang, Z., & Young, M. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00219 · Cited by 63 · see citing works
Physical Activity in People With Posttraumatic Stress Disorder: A Systematic Review of Correlates
Vancampfort, D., Richards, J. A., Stubbs, B., Akello, G., Gbiri, C. A., Ward, P. B., & Rosenbaum, S. (2016) · Journal of Physical Activity and Health · doi:10.1123/jpah.2015-0436 · Cited by 63 · see citing works
Clive, M. L., Boks, M. P., Vinkers, C. H., Osborne, L. M., Payne, J. L., Ressler, K. J., Smith, A. K., Wilcox, H. C., & Kaminsky, Z. A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0279-1 · Cited by 81 · see citing works
Friend, S. F., Nachnani, R., Powell, S. B., & Risbrough, V. B. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15031 · Cited by 63 · see citing works
Yu, G., Liu, Z., Wu, X., Becker, B., Zhang, K., Fan, H., Peng, S., Kuang, N., Kang, J., Dong, G., et al. (2023) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.220202 · Cited by 63 · see citing works
Olff, M., & van Zuiden, M. (2017) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2017.01.001 · Cited by 60 · see citing works
Reber, S. O., Langgartner, D., Foertsch, S., Postolache, T. T., Brenner, L. A., Guendel, H., & Lowry, C. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.08.031 · Cited by 59 · see citing works
Jaffe, A. E., Tao, R., Tran, M. N., Page, S. C., Maynard, K. R., Pattie, E. A., Nguyen, C. V., Deep‐Soboslay, A., Bharadwaj, R., Young, K. A., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21020162 · Cited by 58 · see citing works
Physical fitness in people with posttraumatic stress disorder: a systematic review
Vancampfort, D., Stubbs, B., Richards, J. A., Ward, P. B., Firth, J., Schuch, F. B., & Rosenbaum, S. (2016) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1226412 · Cited by 75 · see citing works
Eswarappa, M. S., Neylan, T. C., Whooley, M. A., Metzler, T. J., & Cohen, B. E. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.10.012 · Cited by 56 · see citing works
A review of the pathology and treatment of TBI and PTSD
Monsour, M., Ebedes, D. M., & Borlongan, C. V. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114009 · Cited by 55 · see citing works
Bruenig, D., Mehta, D., Morris, C. P., Harvey, W., Lawford, B. R., Young, R. M., & Voisey, J. (2017) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2017.01.015 · Cited by 55 · see citing works
Lindqvist, D., Mellon, S. H., Dhabhar, F. S., Yehuda, R., Grenon, S. M., Flory, J. D., Bierer, L. M., Amara, D. A., Coy, M., Makotkine, I., et al. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.052 · Cited by 55 · see citing works
Neuroinflammatory genes associated with post-traumatic stress disorder
Zass, L. J., Hart, S. A., Seedat, S., Hemmings, S. M. J., & Malan‐Müller, S. (2016) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000143 · Cited by 52 · see citing works
Sex differences in post-traumatic stress disorder risk: autonomic control and inflammation
Fonkoue, I. T., Michopoulos, V., & Park, J. (2020) · Clinical Autonomic Research · doi:10.1007/s10286-020-00729-7 · Cited by 53 · see citing works
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- Authors
- Eraly, S. A., Nievergelt, C. M., Maihofer, A. X., Barkauskas, D. A., Biswas, N., Agorastos, A., O’Connor, D. T., & Baker, D. G.
- Affiliations
- University of California San Diego (US)
- University of Southern California (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Baker, Dewleen G.
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2014-04-01
- Volume
- 71
- Issue
- 4
- Pages
- 423
- ISSN
- 2168-622X (ISSN-L)
- PMC
- PMC4032578
- OpenAlex
- W2100635378
- Cited by
- 386
- References
- 81
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 33 · 2023: 47 · 2022: 36 · 2021: 28 · 2020: 27 · 2019: 22 · 2018: 29 · 2017: 37 · 2016: 39 · 2015: 30 · 2014: 10
- FWCI
- 45.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL094728, HL094728)
- National Institute of Mental Health (MH093500, R01MH093500)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- post-traumatic stress disorder, C-reactive protein, biomarkers, peripheral inflammation, combat deployment, military personnel, PTSD risk prediction, zero-inflated negative binomial regression, Clinician-Administered PTSD Scale, PTSD symptom severity, PTSD prevention
- MeSH terms
- Adult, C-Reactive Protein, Combat Disorders, Humans, Inflammation, Longitudinal Studies, Male, Military Personnel, Neuropsychological Tests, Predictive Value of Tests, Prospective Studies, Stress Disorders, Post-Traumatic, Biomarkers, Risk Assessment, Resilience, Psychological
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