The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Role of the Tumor Microenvironment in Breast Cancer
Abstract
In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Various components of the breast cancer microenvironment, such as suppressive immune cells, soluble factors and altered extracellular matrix, act together to impede effective antitumor immunity and promote breast cancer progression and metastasis. Stromal cells in the breast cancer microenvironment are characterized by molecular alterations and aberrant signaling pathways, some of which are prognostic of clinical outcome. Several new therapies targeting stromal components are in development or undergoing clinical trials. We focus herein on the composition of the breast cancer microenvironment and concomitant molecular alterations, the specific interplay between various cell types and cancer cells, and the clinical implications of these findings.
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1 retracted
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Cited by
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Metadata
- Authors
- Soysal, S. D., Tzankov, A., & Muenst, S. E.
- Venue
- Pathobiology
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 82
- Issue
- 3-4
- Pages
- 142-152
- ISSN
- 1015-2008 (ISSN-L)
- 1423-0291
- OpenAlex
- W1488814076
- Cited by
- 510
- References
- 100
- FWCI
- 3.25
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
