The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations
Open accessAbstract
It has long been known that life span is inversely related to resting heart rate in most organisms. This association between heart rate and survival has been attributed to the metabolic rate, which is greater in smaller animals and is directly associated with heart rate. Studies have shown that heart rate is related to survival in apparently healthy individuals and in patients with different underlying cardiovascular diseases. A decrease in heart rate due to therapeutic interventions may result in an increase in survival. However, there are many factors regulating heart rate, and it is quite plausible that these may independently affect life expectancy. Nonetheless, a fast heart rate itself affects the cardiovascular system in multiple ways (it increases ventricular work, myocardial oxygen consumption, endothelial stress, aortic/arterial stiffness, decreases myocardial oxygen supply, other) which, in turn, may affect survival. In this brief review, the effects of heart rate on the heart, arterial system and survival will be discussed.
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Cites
Mittleman, M. A., Maclure, M., Tofler, G. H., Sherwood, J. B., Goldberg, R. J., & Muller, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292301 · Cited by 1,431
Hjalmarson, Å., Goldstein, S., Fagerberg, B., Wedel, H., Waagstein, F., Kjekshus, J., Wikstrand, J., El Allaf, D., Vítovec, J., Aldershvile, J., et al. (2000) · JAMA · doi:10.1001/jama.283.10.1295 · Cited by 1,399
Fox, K., Ford, I., Steg, P. G., Tendera, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61170-8 · Cited by 1,099
Resting Heart Rate in Cardiovascular Disease
Fox, K., Borer, J. S., Camm, A. J., Danchin, N., Ferrari, R., Lopez Sendon, J. L., Steg, P. G., Tardif, J.-C., Tavazzi, L., & Tendera, M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.079 · Cited by 1,062
Self-citationFox, K., Ford, I., Steg, P. G., Tendera, M., Robertson, M., & Ferrari, R. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61171-x · Cited by 789
Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure
Fox, K., Ford, I., Steg, P. G., Tardif, J.-C., Tendera, M., & Ferrari, R. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1406430 · Cited by 486
Tardif, J.-C., O'Meara, E., Komajda, M., Böhm, M., Borer, J. S., Ford, I., Tavazzi, L., & Swedberg, K. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr311 · Cited by 300
Self-citation(1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00246-5 · Cited by 280
Heart rate as marker of sympathetic activity
Grassi, G., Vailati, S., Bertinieri, G., Seravalle, G., Stella, M. L., DellʼOro, R., & Mancia, G. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816110-00010 · Cited by 279
Inappropriate sinus tachycardia
Olshansky, B., & Sullivan, R. M. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.074 · Cited by 182
Cited by
Law, M. R., Morris, J. K., & Wald, N. J. (2009) · BMJ · doi:10.1136/bmj.b1665 · Cited by 2,775
Monitoring of the central blood pressure waveform via a conformal ultrasonic device
Wang, C., Li, X., Hu, H., Zhang, L., Huang, Z., Lin, M., Zhang, Z., Yin, Z., Huang, B., Gong, H., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0287-x · Cited by 895
Cardiovascular remodelling in coronary artery disease and heart failure
Heusch, G., Libby, P., Gersh, B., Yellon, D., Böhm, M., Lopaschuk, G., & Opie, L. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60107-0 · Cited by 734
Central blood pressure: current evidence and clinical importance
McEniery, C. M., Cockcroft, J. R., Roman, M. J., Franklin, S. S., & Wilkinson, I. B. (2014) · European Heart Journal · doi:10.1093/eurheartj/eht565 · Cited by 678
Cleland, J. G. F., Bunting, K. V., Flather, M. D., Altman, D. G., Holmes, J., Coats, A. J. S., Manzano, L., McMurray, J. J. V., Ruschitzka, F., van Veldhuisen, D. J., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx564 · Cited by 659
Metadata
- Authors
- Boudoulas, K. D., Borer, J. S., & Boudoulas, H.
- Venue
- Cardiology
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 132
- Issue
- 4
- Pages
- 199-212
- ISSN
- 0008-6312 (ISSN-L)
- 1421-9751
- OpenAlex
- W1811184201
- Cited by
- 1,938
- References
- 11
- FWCI
- 114.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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