Monitoring of the central blood pressure waveform via a conformal ultrasonic device
Open accessAbstract
Continuous monitoring of the central blood pressure waveform from deeply embedded vessels such as the carotid artery and jugular vein has clinical value for the prediction of all-cause cardiovascular mortality. However, existing non-invasive approaches, including photoplethysmography and tonometry, only enable access to the superficial peripheral vasculature. Although current ultrasonic technologies allow non-invasive deep tissue observation, unstable coupling with the tissue surface resulting from the bulkiness and rigidity of conventional ultrasound probes introduces usability constraints. Here, we describe the design and operation of an ultrasonic device that is conformal to the skin and capable of capturing blood pressure waveforms at deeply embedded arterial and venous sites. The wearable device is ultrathin (240 μm) and stretchable (with strains up to 60%), and enables the non-invasive, continuous and accurate monitoring of cardiovascular events from multiple body locations, which should facilitate its use in a variety of clinical environments. An ultrasonic and stretchable device conformal to the skin that captures blood pressure waveforms at deeply embedded arterial and venous sites enables the continuous monitoring of cardiovascular events.
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Other flexible health monitoring mechanisms like optoelectronic and ultrasound devices can be applied to heartbeat, pulse oximetry, blood pressure, and other on-body measurements.
“Other mechanisms of flexible health monitoring in rehabilitation, like optoelectronic[263,264] and ultrasound[265,266] devices, can also be applied to heartbeat, pulse oximetry, blood pressure, and other on-body measurements.”
From Flexible Electronics and Devices as Human–Machine Interfaces for Medical Robotics (2022) · cites this paper as [266]
The Abstract describes a wearable, skin-conformal ultrasonic device that continuously monitors blood-pressure waveforms. The Results (‘Dynamic hemodynamics monitoring’) also report heart-rate measurements. Our copy does not show this ultrasonic device measuring pulse oximetry, so it supports only part of the measurement list attributed to it. (LLM, conf=0.84)
Experimental — accuracy not yet measuredA novel spiked ultra-flexible neural interface (SUNI) collected sensory information from rat mechanoreceptors through a spike structure.
“Figure 4b displayed a novel spiked ultra-flexible neural interface (SUNI), which collected sensory information from rat mechanoreceptors through the spike structure (Wang, J. et al., 2018).”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Wang, J. et al., 2018
High-quality recordings from SUNI contributed to differentiating tactile and proprioceptive stimuli and provided for high spatial resolution classification of neural signals.
“High-quality recordings from SUNI contributed differentiate tactile and proprioceptive stimuli, and furtherly provided for high spatial resolution classification of neural signals.”
From Artificial intelligence enhanced sensors - enabling technologies to next-generation healthcare and biomedical platform (2023) · cites this paper as Wang, J. et al., 2018
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- Authors
- Wang, C., Li, X., Hu, H., Zhang, L., Huang, Z., Lin, M., Zhang, Z., Yin, Z., Huang, B., Gong, H., Bhaskaran, S., Gu, Y., Makihata, M., Guo, Y., Lei, Y., Chen, Y., Wang, C., Li, Y., Zhang, T., Chen, Z., Pisano, A. P., Zhang, L., Zhou, Q., & Xu, S.
- Affiliations
- University of California San Diego (US)
- Tianjin University (CN)
- University of Southern California (US)
- Corresponding author
- Xu, Sheng
- ORCID
- Venue
- Nature Biomedical Engineering
- Published
- 2018-09-11
- Volume
- 2
- Issue
- 9
- Pages
- 687-695
- ISSN
- 2157-846X (ISSN-L)
- PMC
- PMC6428206
- OpenAlex
- W2891821958
- Semantic Scholar
- 54036ec5fa00d18b5c4ccbf2436f52e6b3707b01
- Cited by
- 895
- References
- 50
- Citations by year
- 2026: 90 · 2025: 157 · 2024: 124 · 2023: 134 · 2022: 118 · 2021: 120 · 2020: 97 · 2019: 52 · 2018: 3
- FWCI
- 27.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (1r21eb025521-01)
- National Institute of Biomedical Imaging and Bioengineering (R21 EB025521)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- central blood pressure, blood pressure waveform, wearable ultrasound device, stretchable sensors, carotid artery, jugular vein, deep tissue imaging, non-invasive blood pressure monitoring, cardiovascular mortality prediction
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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