The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation
Open accessAbstract
Background/Aims: Bone marrow mesenchymal stem cells (MSCs) widely applied for treating myocardial infarction face survival challenges in the inflammatory and ischemia microenvironment of acute myocardial infarction. The study hypothesized that MSC-derived exosomes play a significant role in improving microenvironment after acute myocardial infarction and aimed to investigate the paracrine effects of exosomes on angiogenesis and anti-inflammatory activity. Methods: MSCs were cultured in DMEM/F12 supplemented with 10% exosome-depleted fetal bovine serum and 1% penicillin-streptomycin for 48 h. MSC-derived exosomes were isolated using ExoQuick-TC. Tube formation and T-cell proliferation assays were performed to assess the angiogenic potency of MSC-derived exosomes. Acute myocardial infarction was induced in Sprague-Dawley rats, and myocardium bordering the infarcted zone was injected at four different sites with phosphate-buffered saline (PBS, control), MSC-derived exosomes, and exosome-depleted MSC culture medium. Results: MSC-derived exosomes significantly enhanced the tube formation of human umbilical vein endothelial cells, impaired T-cell function by inhibiting cell proliferation in vitro, reduced infarct size, and preserved cardiac systolic and diastolic performance compared with PBS markedly enhancing the density of new functional capillary and hence blood flow recovery in rat myocardial infarction model. Conclusions: Exosomes stimulate neovascularization and restrain the inflammation response, thus improving heart function after ischemic injury.
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Cites
Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury
Lai, R. C., Arslan, F., Lee, M. M., Sze, N. S. K., Choo, A., Chen, T. S., Salto-Tellez, M., Timmers, L., Lee, C. N., El Oakley, R. M., et al. (2010) · Stem Cell Research · doi:10.1016/j.scr.2009.12.003 · Cited by 2,215
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Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
Bruno, S., Grange, C., Deregibus, M. C., Calogero, R. A., Saviozzi, S., Collino, F., Morando, L., Busca, A., Falda, M., Bussolati, B., et al. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008070798 · Cited by 1,330
Regulation of the Inflammatory Response in Cardiac Repair
Frangogiannis, N. G. (2012) · Circulation Research · doi:10.1161/circresaha.111.243162 · Cited by 1,194
Exosomes/microvesicles as a mechanism of cell-to-cell communication
Camussi, G., Deregibus, M. C., Bruno, S., Cantaluppi, V., & Biancone, L. (2010) · Kidney International · doi:10.1038/ki.2010.278 · Cited by 1,178
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Lee, C., Mitsialis, S. A., Aslam, M., Vitali, S. H., Vergadi, E., Konstantinou, G., Sdrimas, K., Fernandez-Gonzalez, A., & Kourembanas, S. (2012) · Circulation · doi:10.1161/circulationaha.112.114173 · Cited by 793
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Cited by
Concise review: MSC-derived exosomes for cell-free therapy
Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834
Gurunathan, S., Kang, M.-H., Jeyaraj, M., Qasim, M., & Kim, J.-H. (2019) · Cells · doi:10.3390/cells8040307 · Cited by 1,122
Mesenchymal stem cell-derived exosomes as a new therapeutic strategy for liver diseases
Lou, G., Chen, Z., Zheng, M., & Liu, Y. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.63 · Cited by 601
Mesenchymal stromal cell secretome: influencing therapeutic potential by cellular pre-conditioning
Ferreira, J. R., Teixeira, G. Q., Santos, S. G., Barbosa, M. A., Almeida-Porada, G., & Gonçalves, R. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02837 · Cited by 572
Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment
Whiteside, T. L. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2017.12.003 · Cited by 308
Metadata
- Authors
- Teng, X., Chen, L., Chen, W., Yang, J., Yang, Z., & Shen, Z.
- Venue
- Cellular Physiology and Biochemistry
- Publisher
- S. Karger AG
- Published
- 2015
- Volume
- 37
- Issue
- 6
- Pages
- 2415-2424
- ISSN
- 1015-8987 (ISSN-L)
- 1421-9778
- OpenAlex
- W2191284640
- Cited by
- 470
- References
- 27
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation. https://app.cochat.ai/papers/10.1159/000438594
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- Teng, X., Chen, L., Chen, W., Yang, J., Yang, Z., & Shen, Z. (2015). Mesenchymal Stem Cell-Derived Exosomes Improve the Microenvironment of Infarcted Myocardium Contributing to Angiogenesis and Anti-Inflammation. Cellular Physiology and Biochemistry. https://doi.org/10.1159/000438594
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
