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Cited by 44Dementia and Cognitive Impairment ResearchHistorical and Modern Theater StudiesAmyotrophic Lateral Sclerosis Research

DAPHNE: a new tool for the assessment of the behavioral variant of frontotemporal dementia

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Boutoleau-Bretonnière, Claire, Evrard, Christelle, Hardouin, Jean Benoît, Rocher, Laëtitia, Charriau, Tiphaine, Etcharry-Bouyx, Frédérique, Auriacombe, Sophie, Richard-Mornas, Aurélie +8 more·2015·Dementia and Geriatric Cognitive Disorders Extra
DOI 10.1159/000440859PMC PMC4777961
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Abstract

Background: The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, justifying development of new clinical tools. Objective: We produced a behavioral inventory named DAPHNE. This scale (adapted from Rascovsky's criteria) explores six domains: disinhibition, apathy, perseverations, hyperorality, personal neglect and loss of empathy. It is composed of ten items (five answer categories). The aim was (1) to assess the validity and reliability of DAPHNE and (2) to evaluate its contribution in differentiating patients. Methods: Two scores were computed: DAPHNE-6 (screening) from the six domains and DAPHNE-40 (diagnosis) from the ten items. Reliability and reproducibility were assessed. External validity was studied with the Frontal Behavioral Inventory (FBI) and the Frontotemporal Behavioral Scale (FBS). Finally, the diagnostic performance of DAPHNE was compared to revised criteria, FBI and FBS. Results: DAPHNE was administered to the caregivers of 89 patients, 36 with bvFTD, 22 with Alzheimer's disease, 15 with progressive supranuclear palsy and 16 with bipolar disorder. Reliability and reproducibility were excellent, as was external validity. DAPHNE-6 allowed bvFTD diagnosis (score ≥4) with a sensitivity of 92%, while DAPHNE-40 (score ≥15) had a specificity of 92%. Conclusion: We demonstrate excellent psychometric features for DAPHNE. This quick tool could help for both diagnosing and screening bvFTD.

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  • DAPHNE demonstrated an ability to distinguish bvFTD from bipolar disorder.

    “DAPHNE, a recently developed informant-based behavioural inventory with 10 items based on the 2011 bvFTD international consensus diagnostic criteria, demonstrated an ability to distinguish bvFTD from bipolar disorder (Boutoleau-Bretonniere et al. , 2015).”

    From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as Boutoleau-Bretonniere et al., 2015

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Authors
Boutoleau-Bretonnière, C., Evrard, C., Hardouin, J. B., Rocher, L., Charriau, T., Etcharry-Bouyx, F., Auriacombe, S., Richard-Mornas, A., Lebert, F., Pasquier, F., Sauvaget, A., Bulteau, S., Vercelletto, M., Derkinderen, P., Bretonnière, C., & Thomas-Antérion, C.
Affiliations
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Nantes (FR)
  • Centre Hospitalier Universitaire de Bordeaux (FR)
  • Centre Hospitalier Universitaire de Lille (FR)
  • Université de Nantes (FR)
  • Université Lumière Lyon 2 (FR)
ORCID
Venue
Dementia and Geriatric Cognitive Disorders Extra
Publisher
S. Karger AG
Published
2015-12-18
Volume
5
Issue
3
Pages
503-516
ISSN
1664-5464 (ISSN-L)
DOI
10.1159/000440859
PMC
PMC4777961
OpenAlex
W2241930123
Cited by
44
References
7
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 3 · 2017: 1 · 2016: 3 · 2015: 1
FWCI
2.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Dementia and Geriatric Cognitive Disorders Extra (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Association France Alzheimer
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
Keywords
behavioral variant frontotemporal dementia, Daphne, disinhibition, apathy, perseveration, hyperorality, personal neglect, loss of empathy, diagnostic screening, psychometric validation, Frontal Behavioral Inventory, Alzheimer's disease, progressive supranuclear palsy, bipolar disorder

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