Dynamic Optical Coherence Tomography in Dermatology
Open accessAbstract
Optical coherence tomography (OCT) represents a non-invasive imaging technology, which may be applied to the diagnosis of non-melanoma skin cancer and which has recently been shown to improve the diagnostic accuracy of basal cell carcinoma. Technical developments of OCT continue to expand the applicability of OCT for different neoplastic and inflammatory skin diseases. Of these, dynamic OCT (D-OCT) based on speckle variance OCT is of special interest as it allows the in vivo evaluation of blood vessels and their distribution within specific lesions, providing additional functional information and consequently greater density of data. In an effort to assess the potential of D-OCT for future scientific and clinical studies, we have therefore reviewed the literature and preliminary unpublished data on the visualization of the microvasculature using D-OCT. Information on D-OCT in skin cancers including melanoma, as well as in a variety of other skin diseases, is presented in an atlas. Possible diagnostic features are suggested, although these require additional validation.
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OCT has potential for monitoring therapy for skin disorders such as scleroderma, psoriasis, eczema, and wound healing.
“It has also been shown to have potential for monitoring therapy for skin disorders such as scleroderma, psoriasis, eczema, and wound healing.96–98”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [98]
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Applications and future directions for optical coherence tomography in dermatology*
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Application of optical coherence tomography in clinical diagnosis
Wang, Y., Liu, S., Lou, S., Zhang, W., Cai, H., & Chen, X. (2019) · Journal of X-Ray Science and Technology: Clinical Applications of Diagnosis and Therapeutics · doi:10.3233/xst-190559 · Cited by 42 · see citing works
- Authors
- Ulrich, M., Themstrup, L., de Carvalho, N., Manfredi, M., Grana, C., Ciardo, S., Kästle, R., Holmes, J., Whitehead, R., Jemec, G. B. E., Pellacani, G., & Welzel, J.
- Affiliations
- MSB Medical School Berlin (DE)
- University of Copenhagen (DK)
- University of Modena and Reggio Emilia (IT)
- VivoSight (United Kingdom) (GB)
- Karger Publishers (Switzerland) (CH)
- ORCID
- Venue
- Dermatology
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 232
- Issue
- 3
- Pages
- 298-311
- ISSN
- 1018-8665 (ISSN-L)
- 1421-9832
- OpenAlex
- W2335931223
- Cited by
- 230
- References
- 55
- Citations by year
- 2026: 19 · 2025: 15 · 2024: 24 · 2023: 22 · 2022: 22 · 2021: 29 · 2020: 18 · 2019: 22 · 2018: 26 · 2017: 24 · 2016: 9
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Dermatology (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Optical Coherence Tomography Applications
- Health Sciences › Medicine › Oncology › Cutaneous Melanoma Detection and Management
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- dynamic optical coherence tomography, skin microcirculation, non-melanoma skin cancer, basal cell carcinoma, melanoma, skin cancer diagnosis, skin diseases, in vivo imaging
- MeSH terms
- Dermatology, Humans, Skin, Skin Diseases, Tomography, Optical Coherence
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