The Relationship between Behavioural Changes, Cognitive Symptoms, and Functional Disability in Primary Progressive Aphasia: A Longitudinal Study
Open accessAbstract
Background: The contribution of behavioural changes to functional decline is yet to be explored in primary progressive aphasia (PPA). Objectives: (1) investigate functional changes in two PPA variants [semantic (svPPA) and non-fluent (nfvPPA)], at baseline and after 12 months; (2) investigate baseline differences in behavioural changes between groups, and (3) explore predictors of functional decline after a 12-month period. Methods: A longitudinal study involving 29 people with PPA (18 svPPA; 11 nfvPPA) seen annually in Sydney/Australia was conducted. A total of 114 functional and behavioural assessments were included for within-group (repeated-measures ANOVA; annual rate of change; multiple regression analyses) and between-group analyses (pairwise comparisons). Results: Functional profiles in svPPA and nfvPPA were similar in people with up to 5 years of disease duration. Behavioural changes were marked in svPPA patients (stereotypical behaviour and apathy) but did not predict annual rate of change of functional abilities; global cognitive scores at baseline did. Despite mild behavioural changes in nfvPPA (disinhibition, apathy), these were significant predictors of annual rate of functional change. Conclusions: The presentation and interplay of behavioural changes and functional disability differ in svPPA and nfvPPA. These varying factors should be taken into account when considering prognosis, disease management, and selection of outcome measures for interventions.
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ADL deficits do not always show association with cognitive scores in various dementia subtypes.
“Moreover, ADL deficits do not always show association with cognitive scores in various dementia subtypes (Mioshi et al., 2007; O'Connor, Clemson, Flanagan, et al., 2016; O'Connor, Clemson, Hornberger, et al., 2016), highlighting the importance of including ADL scores in studies investigating wellbeing of carers of people with dementia.”
From Exploring the impact of carer stressors and psychological inflexibility on depression and anxiety in family carers of people with dementia (2020) · cites this paper as O'Connor, Clemson, Flanagan, et al., 2016
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- Authors
- O'Connor, C. M., Clemson, L., Flanagan, E., Kaizik, C., Brodaty, H., Hodges, J. R., Piguet, O., & Mioshi, E.
- Affiliations
- The University of Sydney (AU)
- Neuroscience Research Australia (AU)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 42
- Issue
- 3-4
- Pages
- 215-226
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W2524746460
- Cited by
- 27
- References
- 47
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 2 · 2017: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- ueaeprints.uea.ac.uk
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Alzheimer Society
- National Health and Medical Research Council (1036639, 1103258)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- primary progressive aphasia, semantic dementia, behavior change, functional disability, functional decline, apathy, disinhibition, stereotypy, cognitive symptoms, predictors of functional decline, prognosis
- MeSH terms
- Activities of Daily Living, Aged, Australia, Cognition, Female, Humans, Longitudinal Studies, Male, Middle Aged, Semantics, Disease Progression, Aphasia, Primary Progressive, Apathy, Cognitive Dysfunction
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