Activities of daily living in frontotemporal dementia and Alzheimer disease
Abstract
OBJECTIVE: To evaluate activities of daily living (ADLs) in three clinical variants of frontotemporal dementia and the relationship to cognitive dysfunction. METHODS: Fifty-nine patients and caregivers participated in this cross-sectional study: behavioral variant frontotemporal dementia (bv-FTD, n = 15), progressive nonfluent aphasia (PNFA, n = 10), semantic dementia (n = 15), and Alzheimer disease (AD, n = 19). Caregivers were interviewed with the Disability Assessment for Dementia (DAD) to provide two outcome measures about ADLs: basic and instrumental ADLs (BADLs, IADL). In addition, patients were rated on the Clinical Dementia Rating Scale (CDR), and performance on cognitive measures (Addenbrooke's Cognitive Examination Revised [ACE-R]) was assessed. RESULTS: On the DAD, the bv-FTD group was most affected (56% of normal), whereas PNFA and semantic dementia patients were least impaired (83% and 85%); AD was intermediate (76%). The opposite pattern was seen on the ACE-R, where PNFA and semantic dementia groups were most affected, and bv-FTD showed least impairment; AD was again intermediate. Scores on the DAD did not correlate with cognitive measures, CDR, or disease duration. We further analyzed which aspect of ADLs was most affected, and a unique pattern of deficits emerged for the bv-FTD group (initiation affected > planning > execution for BADLs). CONCLUSION: Frontotemporal dementia has a devastating effect on activities of daily living, which is of considerable importance to caregivers and not captured by bedside cognitive tests.
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ADL deficits do not always show association with cognitive scores in various dementia subtypes.
“Moreover, ADL deficits do not always show association with cognitive scores in various dementia subtypes (Mioshi et al., 2007; O'Connor, Clemson, Flanagan, et al., 2016; O'Connor, Clemson, Hornberger, et al., 2016), highlighting the importance of including ADL scores in studies investigating wellbeing of carers of people with dementia.”
From Exploring the impact of carer stressors and psychological inflexibility on depression and anxiety in family carers of people with dementia (2020) · cites this paper as Mioshi et al., 2007
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- Authors
- Mioshi, E., Kipps, C. M., Dawson, K., Mitchell, J., Graham, A., & Hodges, J. R.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- Venue
- Neurology
- Published
- 2007-06-12
- Volume
- 68
- Issue
- 24
- Pages
- 2077-2084
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2079397002
- Cited by
- 188
- References
- 52
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 10 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 15 · 2013: 13 · 2012: 7
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- Wellcome Trust (073580)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- activities of daily living, frontotemporal dementia, Alzheimer's disease, behavioral variant frontotemporal dementia, progressive nonfluent aphasia, semantic dementia, instrumental activities of daily living, basic activities of daily living, cognitive impairment, caregiver burden, Disability Assessment for Dementia, Clinical Dementia Rating, Addenbrooke's Cognitive Examination-Revised
- MeSH terms
- Activities of Daily Living, Aged, Alzheimer Disease, Cognition Disorders, Cross-Sectional Studies, Dementia, Disability Evaluation, Educational Status, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Age Distribution, Sex Distribution
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