The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
Abstract
BACKGROUND/AIMS: Our previous study confirmed that Aloe sterol stimulates collagen and hyaluronic acid production in human dermal fibroblasts. This study aims to investigate whether Aloe sterol intake affects skin conditions. METHODS: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin elasticity, hydration, and the collagen score in 64 healthy women (age range 30-59 years; average 44.3 years) who were randomly assigned to receive either a placebo or an Aloe sterol-supplemented yogurt. Skin parameters were measured and ultrasound analysis of the forearm was performed. RESULTS: ANCOVA revealed statistical differences in skin moisture, transepidermal water loss, skin elasticity, and collagen score between the Aloe sterol and placebo groups. The gross elasticity (R2), net elasticity (R5), and biological elasticity (R7) scores of the Aloe sterol group significantly increased with time. In addition, skin fatigue area F3, which is known to decrease with age and fatigue, also increased with Aloe sterol intake. Ultrasound echogenicity revealed that the collagen content in the dermis increased with Aloe sterol intake. CONCLUSION: The results suggest that continued Aloe sterol ingestion contributes to maintaining healthy skin.
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“The group later demonstrated that oral supplementation with aloe sterol also significantly increased skin elasticity, hydration, and the collagen score in women’s inner forearm skin [136].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [136]
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Transmembrane crosstalk between the extracellular matrix and the cytoskeleton
Geiger, B., Bershadsky, A. D., Pankov, R. G., & Yamada, K. M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35099066 · Cited by 2,213
Pathophysiology of Premature Skin Aging Induced by Ultraviolet Light
Fisher, G. J., Wang, Z., Datta, S. C., Varani, J., Kang, S., & Voorhees, J. J. (1997) · New England Journal of Medicine · doi:10.1056/nejm199711133372003 · Cited by 1,501
Molecular basis of sun-induced premature skin ageing and retinoid antagonism
Fisher, G. J., Datta, S. C., Talwar, H. S., Wang, Z.-Q., Varani, J., Kang, S., & Voorhees, J. J. (1996) · Nature · doi:10.1038/379335a0 · Cited by 1,410
Chinetti, G., Fruchart, J.-C., & Staels, B. (2000) · Inflammation Research · doi:10.1007/s000110050622 · Cited by 954
Decreased Collagen Production in Chronologically Aged Skin
Varani, J., Dame, M. K., Rittie, L., Fligiel, S. E. G., Kang, S., Fisher, G. J., & Voorhees, J. J. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.051302 · Cited by 910
Fibroblast biology in three-dimensional collagen matrices
Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819
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Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468
The extracellular matrix in development and morphogenesis: A dynamic view
Rozario, T., & DeSimone, D. W. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.026 · Cited by 1,537
Mechanisms of nanotoxicity: Generation of reactive oxygen species
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Diversity and biology of cancer-associated fibroblasts
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Hyaluronic acid: A key molecule in skin aging
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031
Metadata
- Authors
- Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F.
- Affiliations
- Morinaga Milk Industry Co., Ltd. (Japan) (JP)
- Wakayama Medical University (JP)
- Venue
- Skin Pharmacology and Physiology
- Publisher
- S. Karger AG
- Published
- 2016
- Volume
- 29
- Issue
- 6
- Pages
- 309-317
- ISSN
- 1422-2868 (ISSN-L)
- 1660-5527
- 1660-5535
- OpenAlex
- W2573540928
- Cited by
- 1,092
- References
- 71
- Citations by year
- 2026: 4 · 2025: 36 · 2024: 129 · 2023: 140 · 2022: 139 · 2021: 78 · 2020: 75 · 2019: 76 · 2018: 74 · 2017: 74 · 2016: 59
- FWCI
- 113.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Skin Pharmacology and Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activity of medicinal plants
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- dietary supplementation, skin elasticity, skin hydration, transepidermal water loss, collagen content, skin collagen, skin aging, Aloe vera, women
- MeSH terms
- Administration, Oral, Adult, Aloe, Collagen, Double-Blind Method, Elasticity, Female, Humans, Middle Aged, Skin, Sterols, Water, Dietary Supplements
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