Fibroblast biology in three-dimensional collagen matrices
Abstract
Research on fibroblast biology in three-dimensional collagen matrices offers new opportunities to understand the reciprocal and adaptive interactions that occur between cells and surrounding matrix in a tissue-like environment. Such interactions are integral to the regulation of connective tissue morphogenesis and dynamics that characterizes tissue homeostasis and wound repair. During fibroblast-collagen matrix remodeling, mechanical signals from the remodeled matrix feed back to modulate cell behavior in an iterative process. As mechanical loading (tension) within the matrix increases, the mechanisms used by cells to remodel the matrix change. Fibroblasts in matrices that are under tension or relaxed respond differently to growth factor stimulation, and switching between mechanically loaded and unloaded conditions influences whether cells acquire proliferative/biosynthetic active or quiescent/resting phenotypes.
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The secretory phenotype of senescent fibroblasts resembles that of fibroblasts undergoing a wounding response, which entails local remodeling of the tissue structure.
“In many ways, the secretory phenotype of senescent fibroblasts resembles that of fibroblasts undergoing a wounding response, which entails local remodeling of the tissue structure (Grinnell, 2003).”
From Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors (2005) · cites this paper as Grinnell, 2003
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- Authors
- Grinnell, F.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Grinnell, Frederick
- ORCID
- Grinnell, Frederick
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 13
- Issue
- 5
- Pages
- 264-269
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2050742799
- Cited by
- 819
- References
- 67
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 15 · 2023: 22 · 2022: 16 · 2021: 25 · 2020: 29 · 2019: 27 · 2018: 28 · 2017: 26 · 2016: 39 · 2015: 42 · 2014: 41 · 2013: 55 · 2012: 48
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (GM 31321)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- fibroblasts, collagen matrix, 3D cell culture, cell-matrix interactions, matrix remodeling, mechanical loading, tissue mechanics, growth factor signaling, cell proliferation, quiescent cells, wound healing, tissue homeostasis
- MeSH terms
- Animals, Cell Adhesion, Collagen, Dendrites, Fibroblasts, Humans, Models, Biological, Phenotype, Wound Healing
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