Cited by 819Cellular Mechanics and InteractionsWound Healing and TreatmentsTGF-β signaling in diseases

Fibroblast biology in three-dimensional collagen matrices

Grinnell, Frederick·2003·Trends in Cell Biology

Abstract

Research on fibroblast biology in three-dimensional collagen matrices offers new opportunities to understand the reciprocal and adaptive interactions that occur between cells and surrounding matrix in a tissue-like environment. Such interactions are integral to the regulation of connective tissue morphogenesis and dynamics that characterizes tissue homeostasis and wound repair. During fibroblast-collagen matrix remodeling, mechanical signals from the remodeled matrix feed back to modulate cell behavior in an iterative process. As mechanical loading (tension) within the matrix increases, the mechanisms used by cells to remodel the matrix change. Fibroblasts in matrices that are under tension or relaxed respond differently to growth factor stimulation, and switching between mechanically loaded and unloaded conditions influences whether cells acquire proliferative/biosynthetic active or quiescent/resting phenotypes.

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Crossref · 10.1016/s0962-8924(03)00057-6

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67 of 67 references verified0 citation errors · 0 not checkable

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  • The secretory phenotype of senescent fibroblasts resembles that of fibroblasts undergoing a wounding response, which entails local remodeling of the tissue structure.

    “In many ways, the secretory phenotype of senescent fibroblasts resembles that of fibroblasts undergoing a wounding response, which entails local remodeling of the tissue structure (Grinnell, 2003).”

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Authors
Grinnell, F.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Grinnell, Frederick
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2003-05
Volume
13
Issue
5
Pages
264-269
ISSN
0962-8924 (ISSN-L)
OpenAlex
W2050742799
Cited by
819
References
67
Citations by year
2026: 10 · 2025: 6 · 2024: 15 · 2023: 22 · 2022: 16 · 2021: 25 · 2020: 29 · 2019: 27 · 2018: 28 · 2017: 26 · 2016: 39 · 2015: 42 · 2014: 41 · 2013: 55 · 2012: 48
FWCI
2.69
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (GM 31321)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
fibroblasts, collagen matrix, 3D cell culture, cell-matrix interactions, matrix remodeling, mechanical loading, tissue mechanics, growth factor signaling, cell proliferation, quiescent cells, wound healing, tissue homeostasis
MeSH terms
Animals, Cell Adhesion, Collagen, Dendrites, Fibroblasts, Humans, Models, Biological, Phenotype, Wound Healing

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