The effect of daily versus weekly levothyroxine replacement on thyroid function test in hypothyroid patients at a tertiary care centre in Haryana
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OBJECTIVE: We compare the effect of daily versus weekly levothyroxine (LT4) replacement on thyroid function test (TFT) in hypothyroid patients at a tertiary care centre in Haryana. MATERIALS AND METHODS: This was a randomised crossover study in which 100 hypothyroid patients on a stable LT4 dose were divided into 2 groups of 50 each. In group I, patients were given daily therapy for 6 weeks and then shifted to weekly therapy for the next 6 weeks. In group II, patients were given LT4 once a week for 6 weeks and then switched to daily therapy for the next 6 weeks. TFT, quality of life (QOL), and hyperthyroidism symptom scale (HSS) score of patients were compared in each group at 0, 6, and 12 weeks. RESULTS: = <0.001) and T3/T4 decreased with weekly therapy as compared to daily therapy. No significant difference in HSS score was found between daily and weekly administration of LT4. With weekly therapy, QOL showed improvement in bodily pain, vitality, mental health, and social functioning. CONCLUSION: Once-weekly LT4 administration is a reasonable alternative for patients, especially for those who have issues with compliance.
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Weekly oral LT4 treatment gives slightly less effective control of hypothyroidism, with higher TSH and lower total T3 levels.
“Weekly oral treatment shows slightly less effective control of hypothyroidism, with higher TSH levels and lower total T3 levels.”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [95]
In the short term, weekly oral LT4 treatment produces higher total T4 and free T4 levels, echocardiographic changes, tachycardia, and palpitations, but these do not persist long term.
“In the short term, higher total T4 and free T4 levels are observed, as well as echocardiographic changes, tachycardia, and palpitations, but these symptoms do not persist in the long term.”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [95]
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Cites
(1992) · PubMed · Cited by 33,716 · see citing works
Roberts, C. G., & Ladenson, P. W. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15696-1 · Cited by 567 · see citing works
Saravanan, P., Chau, W. ‐., Roberts, N., Vedhara, K., Greenwood, R., & Dayan, C. M. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01654.x · Cited by 514 · see citing works
Panicker, V., Saravanan, P., Vaidya, B., Evans, J., Hattersley, A. T., Frayling, T. M., & Dayan, C. M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1301 · Cited by 327 · see citing works
Levothyroxine Therapy in Patients with Thyroid Disease
Mandel, S. J., Brent, G. A., & Larsen, P. R. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-119-6-199309150-00009 · Cited by 324 · see citing works
Peeters, R. P., van Toor, H., Klootwijk, W., de Rijke, Y. B., Kuiper, G. G. J. M., Uitterlinden, A. G., & Visser, T. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021592 · Cited by 242 · see citing works
Replacement Dosage of L-Thyroxine in Hypothyroidism: A Re-Evaluation
Stock, J. M., Surks, M. I., & Oppenheimer, J. H. (1974) · New England Journal of Medicine · doi:10.1056/nejm197403072901001 · Cited by 184 · see citing works
Lum, S. M. C., Nicoloff, J. T., Spencer, C. A., & Kaptein, E. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111245 · Cited by 119 · see citing works
Treatment of Hypothyroidism with Once Weekly Thyroxine1
Grebe, S. K. G., Cooke, R. R., Ford, H. C., Fagerström, J. N., Cordwell, D. P., Lever, N. A., Purdie, G., & Feek, C. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.3.3830 · Cited by 95 · see citing works
Symptom Rating Scale for Assessing Hyperthyroidism
Klein, I. L. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380020131018 · Cited by 94 · see citing works
Torlontano, M., Durante, C., Torrente, I., Crocetti, U., Augello, G., Ronga, G., Montesano, T., Travascio, L., Verrienti, A., Bruno, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1067 · Cited by 92 · see citing works
Once weekly thyroxine treatment as a strategy to treat non-compliance
Rangan, S., Tahrani, A. A., Macleod, A. F., & Moulik, P. K. (2007) · Postgraduate Medical Journal · doi:10.1136/pgmj.2007.060244 · Cited by 42 · see citing works
Bornschein, A., Paz-Filho, G., Graf, H., & de Carvalho, G. A. (2012) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302012000400006 · Cited by 28 · see citing works
Symptom rating scale for assessing hyperthyroidism
Klein, I. L. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.148.2.387 · Cited by 25 · see citing works
Dayal, D., Saini, L. K., Attri, S. V., Singh, B., & Bhalla, A. K. (2013) · Intern J Endocrinol Metab · doi:10.5812/ijem.9499 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Altunta F, Uysal AR, Erol C: Twice weekly LT4 for the treatment of primary hypothy- roidism. Turk J Endocrinol Metab 2004; 1:25- 34.
- Ware JE, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). Med Care 1992; 30:473-483.
Cited by
Sorted by citations
Poly(caprolactone)-based subcutaneous implant for sustained delivery of levothyroxine
Stewart, S. A., Domínguez-Robles, J., Utomo, E., Picco, C. J., Corduas, F., Mancuso, E., Amir, M. N., Bahar, M. A., Sumarheni, S., Donnelly, R. F., et al. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121011 · Cited by 35 · see citing works
Ahluwalia, R., Baldeweg, S. E., Boelaert, K., Chatterjee, K., Dayan, C., Okosieme, O., Priestley, J., Taylor, P., Vaidya, B., Zammitt, N., et al. (2023) · Clinical Endocrinology · doi:10.1111/cen.14935 · Cited by 34 · see citing works
“If medication adherence appears to be an issue, one potential strategy has been the use of once or twice weekly directly observed oral therapy, although successful studies to date have been small.(37,38) 208 | AHLUWALIA ET AL.”
BackgroundExperience of switching from a daily to a less frequent administration of injection treatments
Loftus, J., Yaworsky, A., Roland, C. L., Turner‐Bowker, D. M., McLafferty, M., Su, S., & Lamoureux, R. E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278293 · Cited by 24 · see citing works
Refractory hypothyroidism: unraveling the complexities of diagnosis and management
Quiroz-Aldave, J. E., Concepción-Zavaleta, M. J., Durand-Vásquez, M. D. C., Concepción-Urteaga, L. A., Gamarra-Osorio, E. R., Suárez-Rojas, J., Rafael-Robles, L. D. P., Paz-Ibarra, J., & Román-González, A. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.09.003 · Cited by 14 · see citing works
Management of thyroid dysfunction and thyroid nodules in the ageing patient
Martínez‐Montoro, J. I., Doulatram‐Gamgaram, V. K., Olveira, G., Valdés, S., & Fernández‐García, J. C. (2023) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2023.06.005 · Cited by 13 · see citing works
Elsherbiny, T. M. (2022) · Endocrine · doi:10.1007/s12020-022-03242-1 · Cited by 13 · see citing works
Efficacy and Safety of Once-Weekly Thyroxine for Thyroxine-Resistant Hypothyroidism
Chellama, J., Nair, A., Khadar, J. P., Das, D., Prasad, N., Jessy, S. J., Gopi, A., & Guruprasad, P. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00212 · Cited by 13 · see citing works
Weekly Versus Daily Levothyroxine Tablet Replacement in Adults with Hypothyroidism: A Meta-Analyis
Chiu, H. H. C., Larrazabal, R. B., Uy, A. B., & Jimeno, C. (2021) · Journal of the ASEAN Federation of Endocrine Societies · doi:10.15605/jafes.036.02.07 · Cited by 12 · see citing works
Dutta, D., Jindal, R., Kumar, M., Mehta, D., Dhall, A., & Sharma, M. (2021) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_789_20 · Cited by 10 · see citing works
Belal, M. M., Youssef, A. R., Baker, H., Elalaky, N. A., Marey, A. A., Quaisy, M. A., & Rabea, E. M. (2024) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-023-03526-z · Cited by 10 · see citing works
Subclinical hypothyroidism in adults: Consensus statement of Indian thyroid society
Rajput, R., Bajaj, S., Kalra, P., Menon, A. S., Pillai, M. G., Ghosh, S. K., Joshi, S., Seshadri, K., Kumar, P. R. G., Jayakumar, R., et al. (2022) · Thyroid Research and Practice · doi:10.4103/trp.trp_4_23 · Cited by 7 · see citing works
Self-citationKerrigan, L., Stewart, S. A., Domínguez‐Robles, J., Brady, A. J., Ammar, A. A., Donnelly, R. F., Permana, A. D., & Larrañeta, E. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104861 · Cited by 7 · see citing works
Bianchini, B. V., de Jesus, P. R., de Mello, R. G. B., Ziegelmann, P. K., Filion, K. B., & Pizzol, T. D. S. D. (2024) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2024.2313616 · Cited by 6 · see citing works
Twice or thrice weekly versus daily thyroxine in hypothyroid fasting ramadan: A pilot study
Elsherbiny, T. M. (2022) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_1_22 · Cited by 5 · see citing works
Topf, A., Pleininger, T., Motloch, L. J., Mirna, M., Kopp, K. L., Lichtenauer, M., Hoppe, U. C., & Salmhofer, H. (2021) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000349 · Cited by 4 · see citing works
Pasandideh, R., Hosseini, S. M., Veghari, G., & Hezarkhani, S. (2019) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666191105123005 · Cited by 3 · see citing works
Elsherbiny, T. M. (2023) · Thyroid Research · doi:10.1186/s13044-023-00187-z · Cited by 3 · see citing works
Management of endocrine conditions at the end of life
de Bray, A., Tomas, J., Gittoes, N. J. L., & Hassan-Smith, Z. K. (2020) · British Journal of Hospital Medicine · doi:10.12968/hmed.2020.0096 · Cited by 2 · see citing works
Intravenous levothyroxine stewardship program at a tertiary academic medical center
Marino, K. K., Crowley, K. E., Tran, L. K., Sylvia, D., Dell’Orfano, H., DeGrado, J. R., & Szumita, P. M. (2021) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/zxab155 · Cited by 1 · see citing works
Optimizing Levothyroxine Replacement in Primary Care Practice
Gunasekaran, K., & Tan, N. C. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1005906 · Cited by 2 · see citing works
da Rocha, B. S., Silveira, V. B., Rados, D. R. V., Zanella, A. B., Scheffel, R. S., Maia, A. L., & Dora, J. M. (2025) · Endocrine · doi:10.1007/s12020-025-04229-4 · Cited by 2 · see citing works
Singh, R., & Tandon, A. (2025) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_525_24 · Cited by 1 · see citing works
Mathuriya, G., & Panday, S. (2021) · International Journal of Clinical Obstetrics and Gynaecology · doi:10.33545/gynae.2021.v5.i4c.982 · Cited by 1 · see citing works
Nygaard, B. (2022) · doi:10.1093/med/9780198870197.003.0072 · Cited by 1 · see citing works
Khare, J., Bhatnagar, A., Bansal, S., & Jindal, S. (2024) · Thyroid Research and Practice · doi:10.4103/trp.trp_28_23 · Cited by 1 · see citing works
Mathew, E., Stewart, S. A., Utomo, E., Larrañeta, E., & Lamprou, D. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821749-8.00003-3 · Cited by 1 · see citing works
Thyroid dysfunction in the ageing patient
Bilookyi, O. V., Vasiuk, V. L., & Shupik, O. A. (2024) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.20.2.2024.1376
Twice or Thrice Weekly versus Daily Thyroxine in Hypothyroid Fasting Ramadan
Elsherbiny, T. M. (2022) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_1_2
Khare, J., Gupta, S., Suran, A., Mudraje, S., Bansal, S., & Jindal, S. (2025) · Thyroid Research and Practice · doi:10.4103/trp.trp_40_24
Salih, A. M., Muhialdeen, A. S., Ahmed, M. M., Zahir, H. M., Saeed, Y. A., Ali, S. H., Baba, H. O., Ahmed, S. F., Ali, M. B. A., Hassan, H. A., et al. (2025) · Barw Medical Journal · doi:10.58742/bmj.v4i1.211
AlHassan, B. G., Malik, M. M., Mohamedain, A., Jehangir, A., Ayub, F., Musa, O., Ibrahim, A., Qureshi, H. A., & Giha, H. A. (2026) · Clinics and Practice · doi:10.3390/clinpract16060116
- Authors
- Rajput, R., & Pathak, V.
- Affiliations
- Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (IN)
- Corresponding author
- Rajput, Rajesh
- Venue
- European Thyroid Journal
- Publisher
- Bioscientifica
- Published
- 2017-08-03
- Volume
- 6
- Issue
- 5
- Pages
- 250-254
- ISSN
- 2235-0640 (ISSN-L)
- 2235-0802
- PMC
- PMC5649268
- OpenAlex
- W2742879470
- Cited by
- 31
- References
- 14
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 1 · 2019: 2
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Thyroid Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- levothyroxine, weekly dosing, daily dosing, hypothyroidism, thyroid function tests, thyroid-stimulating hormone, T3/T4 ratio, quality of life, medication adherence
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