Twice-weekly dosing for thyroxine replacement in elderly patients with primary hypothyroidism
Abstract
Seven female patients (mean age 86 years) with proven biochemical primary hypothyroidism were enrolled in a single-blind randomized crossover study, of standard daily versus twice-weekly thyroxine therapy, with each phase of one month's duration. The median daily dose of thyroxine was 100 micrograms (range 75-100 micrograms). Serum levels of thyroid hormones and thyrotrophin were very similar during twice-weekly thyroxine therapy to those during daily therapy and there were no statistically significant differences between trough and peak serum total triiodothyronine, free thyroxine, or thyrotrophin levels or systolic time intervals during twice-weekly thyroxine. Administration of thyroxine twice-weekly to elderly patients with primary hypothyroidism gives effective biochemical thyroid hormone replacement, with no evidence from the systolic time intervals of tissue thyrotoxicosis at expected peak thyroid hormone concentrations. Supervised twice-weekly thyroxine should be considered in patients with primary hypothyroidism who comply poorly with daily dosing.
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Supervised oral therapy (once or twice a week) is one potential strategy to counteract non-adherence, although there have been few successful studies to date and the sample sizes have been small.
“Supervised oral therapy (once or twice a week) is one potential strategy to counteract non-adherence, although there have been few successful studies to date and the sample sizes have been small. 156,157”
From Hypothyroidism (2024) · cites this paper as [156]
Cites
Systolic Time Intervals in Heart Failure in Man
WEISSLER, A. M., HARRIS, W. S., & SCHOENFELD, C. D. (1968) · Circulation · doi:10.1161/01.cir.37.2.149 · Cited by 1,217 · see citing works
Thyroid hormones in the elderly sick: "T4 euthyroidism".
Burrows, A. W., SHAKESPEAR, R. A., Hesch, R. D., Cooper, E., AICKIN, C. M., & Burke, C. W. (1975) · BMJ · doi:10.1136/bmj.4.5994.437 · Cited by 81 · see citing works
Livingston, E. H., Hershman, J. M., Sawin, C. T., & Yoshikawa, T. T. (1987) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1987.tb01338.x · Cited by 56 · see citing works
Thyroid Disease in the Elderly
Hurley, J. R. (1983) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31217-2 · Cited by 47 · see citing works
INHIBITION OF CONVERSION OF THYROXINE TO TRIIODOTHYRONINE IN PATIENTS WITH SEVERE CHRONIC ILLNESS
CARTER, J. N., Eastman, C. J., Corcoran, J. M., et al. (1976) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1976.tb03861.x · Cited by 36 · see citing works
Review: Hypothyroidism in the Elderly
Griffin, J. E. (1990) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199005000-00009 · Cited by 34 · see citing works
Intermittent Therapy with L-Thyroxine
Bernstein, R. S., & ROBBINS, J. J. (1969) · New England Journal of Medicine · doi:10.1056/nejm196912252812603 · Cited by 30 · see citing works
Rall, J. E., Robbins, J., & Lewallen, C. G. (1964) · Elsevier eBooks · doi:10.1016/b978-0-12-395716-0.50011-5 · Cited by 17 · see citing works
THYROID FUNCTION TESTS IN THE ELDERLY IN THE COMMUNITY
HODKINSON, H. M., & Denham, M. J. (1977) · Age and Ageing · doi:10.1093/ageing/6.2.67 · Cited by 14 · see citing works
Systolic time intervals in hypothyroidism: end organ function as a reflection of clinical status.
Plotnick, G. D., Vassar, D. L., Parisi, A. F., et al. (1979) · PubMed · Cited by 11 · see citing works
Systolic time intervals in hypothyroidism
Plotnick, G. D., Vassar, D. L., Parisi, A. F., et al. (1979) · The American Journal of the Medical Sciences · doi:10.1097/00000441-197905000-00003 · Cited by 8 · see citing works
Once-a-week high dose thyroid hormone replacement therapy in a hypothyroid patient.
Naafs, M. A., Hr, F., Pp, B., et al. (1987) · PubMed · Cited by 1 · see citing works
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“A small cross-over trial of daily oral therapy versus twice weekly oral therapy showed no significant differences in trough and peak T4, T3, and TSH concentrations and no differences in systolic time intervals over a 1-month duration of therapy (332).”
Treatment with thyroid hormone
Biondi, B., & Wartofsky, L. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1083 · Cited by 259 · see citing works
Taylor, P. N., Medici, M. M., Hubalewska-Dydejczyk, A., & Boelaert, K. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01614-3 · Cited by 128 · see citing works
Thyroxine replacement: a clinical endocrinologist’s viewpoint
Eligar, V, Taylor, P., Okosieme, O., Leese, G., & Dayan, C. (2016) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1177/0004563216642255 · Cited by 72 · see citing works
Once weekly thyroxine treatment as a strategy to treat non-compliance
Rangan, S., Tahrani, A. A., Macleod, A. F., & Moulik, P. K. (2007) · Postgraduate Medical Journal · doi:10.1136/pgmj.2007.060244 · Cited by 42 · see citing works
Levothyroxine pseudo-malabsorption: testing and treatment in the outpatient setting
Rdzak, G. M., Whitman, L. M., & Inzucchi, S. E. (2018) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018818771433 · Cited by 14 · see citing works
Ducharme, M., Scarsi, C., Bettazzi, E., Mautone, G., Lewis, Y., & Celi, F. S. (2022) · Thyroid · doi:10.1089/thy.2021.0604 · Cited by 13 · see citing works
Dutta, D., Jindal, R., Kumar, M., Mehta, D., Dhall, A., & Sharma, M. (2021) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_789_20 · Cited by 10 · see citing works
- Authors
- Taylor, J., Williams, B. O., Frater, J., Stott, D. J., & Connell, J.
- Affiliations
- Gartnavel General Hospital (GB)
- Western Infirmary (GB)
- Venue
- Journal of International Medical Research
- Publisher
- SAGE Publications
- Published
- 1994-09
- Volume
- 22
- Issue
- 5
- Pages
- 273-277
- ISSN
- 0300-0605 (ISSN-L)
- 1473-2300
- OpenAlex
- W1891687975
- Cited by
- 30
- References
- 12
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of International Medical Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- primary hypothyroidism, thyroxine replacement, twice-weekly dosing, elderly patients, thyroid hormone replacement, serum thyroid hormones, thyroid-stimulating hormone, systolic time intervals, triiodothyronine, free thyroxine, dosing compliance
- MeSH terms
- Aged, Aged, 80 and over, Analysis of Variance, Drug Administration Schedule, Female, Humans, Hypothyroidism, Thyroid Hormones, Thyrotropin, Thyroxine, Single-Blind Method, Cross-Over Studies
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