Once weekly thyroxine treatment as a strategy to treat non-compliance
Open accessAbstract
Hypothyroidism is a common disorder, which is mainly treated in primary rather than secondary care. Once daily thyroxine replacement restores euthyroidism in most patients; some patients, however, remain hypothyroid despite adequate thyroxine replacement. Non-compliance is the most common cause of lack of response to thyroxine treatment. We describe two cases of primary hypothyroidism in which daily thyroxine treatment did not restore biochemical euthyroidism but once weekly thyroxine treatment was successful. In addition we review the evidence and discuss the differential diagnosis of lack of response to thyroxine treatment. Once weekly thyroxine treatment can be a safe, well-tolerated, and effective therapy for patients with non-compliance.
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Supervised oral therapy (once or twice a week) is one potential strategy to counteract non-adherence, although there have been few successful studies to date and the sample sizes have been small.
“Supervised oral therapy (once or twice a week) is one potential strategy to counteract non-adherence, although there have been few successful studies to date and the sample sizes have been small. 156,157”
From Hypothyroidism (2024) · cites this paper as [157]
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- Authors
- Rangan, S., Tahrani, A. A., Macleod, A. F., & Moulik, P. K.
- Affiliations
- Royal Shrewsbury Hospital (GB)
- Corresponding author
- Tahrani, A A
- ORCID
- Tahrani, A A
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-10-01
- Volume
- 83
- Issue
- 984
- Pages
- e3-e3
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- PMC
- PMC2600132
- OpenAlex
- W2021336321
- Cited by
- 42
- References
- 11
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 8 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- primary hypothyroidism, thyroxine replacement, weekly dosing, treatment non-adherence, euthyroidism, differential diagnosis, dosing frequency
- MeSH terms
- Administration, Oral, Drug Administration Schedule, Female, Humans, Hypothyroidism, Middle Aged, Thyroxine, Treatment Refusal
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