Cited by 77Treatment of Major DepressionMental Health Treatment and AccessPsychotherapy Techniques and Applications

Discontinuing Antidepressant Drugs: Lesson from a Failed Trial and Extensive Clinical Experience

Open access
Fava, Giovanni A., Belaise, Carlotta·2018·Psychotherapy and Psychosomatics

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1159/000492693

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Persistent post-withdrawal disorders, defined as rebound symptoms and/or new withdrawal symptoms and/or emerging new psychotic symptoms of another type persisting longer than 6 weeks, have been described after discontinuation of antipsychotics.

    “Persistent post-withdrawal disorders, that is a condition in which rebound symptoms and/or new withdrawal symptoms and/or emerging new psychotic symptoms of another type, such as disorganized behavior, persist longer than 6 weeks, have been described after discontinuation of antipsychotics.”

    From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [22]

    Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured
  • Persistent post-withdrawal supersensitivity psychosis is characterized by rebound and/or new withdrawal psychosis after decrease, discontinuation, or switch of antipsychotics, associated with rapid appearance or reappearance of positive symptoms and emergence of a definite drug-induced movement disorder.

    “Persistent post-withdrawal supersensitivity psychosis is characterized by rebound and/or new withdrawal psychosis occurring after decrease, discontinuation, or switch of antipsychotics which is associated with rapid appearance or reappearance of positive symptoms (i.e., illusion, hallucination, catatonia, Schneider passivity experience, delusion) and with the emergence of one definite drug-induced”

    From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [22]

    Split into 2 atoms — 0 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.

    Experimental — accuracy not yet measured
  • Chouinard et al. concluded that 2 persistent post-withdrawal disorders, tardive dyskinesia and supersensitivity psychosis, were specifically induced by antipsychotics.

    “and that 2 persistent post-withdrawal disorders, tardive dyskinesia and supersensitivity psychosis, were specifically induced by antipsychotics [21, 22, 150, 151].”

    From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [22]

    The References section lists a Chouinard et al. paper titled “Antipsychotic-induced dopamine supersensitivity psychosis,” supporting the antipsychotic association for one named condition. The discussion of persistent postwithdrawal disorder in “The Role of Assessment in Planning Drug Discontinuation” does not identify tardive dyskinesia or supersensitivity psychosis as the two disorders, so the full conclusion is not supported by this copy. (LLM, conf=0.76)

    Experimental — accuracy not yet measured
  • Our review's main finding reflects the poor recognition and insufficient consideration of PAWS in both clinical research and practice.

    “Our review’s main finding thus reflects the poor recognition and insufficient consideration of PAWS in both clinical research and practice (Cosci et al., 2024; Fava and Belaise, 2018; Horowitz and Davies, 2025; Read et al., 2023).”
  • Compared to the steadily increasing number of editorials, commentaries and narrative reviews mentioning PAWS, the lack of high-quality original studies providing reliable evidence on the epidemiology and clinical management of PAWS is striking.

    “Nevertheless, compared to the steadily increasing number of editorials, commentaries and narrative reviews mentioning PAWS (e.g. Chouinard and Chouinard, 2015; Davies et al., 2019; Fava and Belaise, 2018; Fava and Cosci, 2019; Lerner and Klein, 2019), the lack of high-quality original studies providing reliable evidence on the epidemiology and clinical management of PAWS is striking.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

1 of the 56 references couldn’t be matched to a known paper.

Research works printed but not linked: 25

  1. Scholten WD, Batelaan NM, van Oppen P, Smit JH, Hoogendoorn AW, van Megen HJGM, Cath DC, van Balkom AJLM: The ef- ficacy of a group CBT relapse prevention pro- gram for remitted anxiety disorder patients who discontinue antidepressant medication: a randomized controlled trial. Psychother Psychosom 2018; 87: 240-242.
  2. Fava GA, Rafanelli C, Grandi S, Conti S, Bel- luardo P: Prevention of recurrent depression with cognitive behavioral therapy. Arch Gen Psychiatry 1998; 55: 816-820.
  3. Fava GA, Grandi S, Belluardo P, Savron G, Raffi AR, Conti S, Saviotti FM: Benzodiaze- pines and anxiety sensitivity in panic disor- der. Prog Neuropsychopharmacol Biol Psy- chiatry 1994; 18: 1163-1168.
  4. Belaise C, Gatti A, Chouinard VA, Chouinard G: Patient online report of selective serotonin reuptake inhibitor (SSRI) induced persistent postwithdrawal anxiety and mood disorders. Psychother Psychosom 2012; 81: 386-388.
  5. Fava GA, Benasi G, Lucente M, Offidani E, Cosci F, Guidi J: Withdrawal symptoms after serotonin-noradrenaline reuptake inhibitors discontinuation. Psychother Psychosom 2018; 87: 195-203.
  6. Carvalho AF, Sharma MS, Brunoni AR, Vieta E, Fava GA: The safety, tolerability and risks associated with the use of newer generation antidepressant drugs. Psychother Psychosom 2016; 85: 270-288.
  7. Maslej MM, Bolker BM, Russell MJ, Eaton K, Durisko Z, Hollon SD, Swanson GM, Thom- son JA, Mulsant BH, Andrews PW: The mor- tality and myocardial effects of antidepres- sants are moderated by pre-existing cardio- vascular disease. Psychother Psychosom 2017; 86: 268-282.
  8. Huang WS, Bai YM, Hsu JW, Huang KL, Tsai CF, Su TP, Li CT, Lin WC, Tsai SJ, Pan TL, Chen TJ, Chen MH: Use of proton pump in- hibitors and risk of major depressive disorder. Psychother Psychosom 2018; 87: 62-64.
  9. Huijbregts KM, Hoogendoorn AW, Slottje P, van Balkom AJLM, Batelaan NM: Long-term and short-term antidepressant use in general practice. Psychother Psychosom 2017; 86: 362-369.
  10. Warner CH, Bobo W, Warner C, Reid S, Ra- chal J: Antidepressant discontinuation syn- drome. Am Fam Physician 2006; 74: 449-456.
  11. Fava GA, Tomba E: Treatment of comorbid anxiety disorders and depression; in Em- melkamp P, Ehring T (eds): The Wiley Hand- book of Anxiety Disorders. Chichester, Wi- ley, 2014, pp 1165-1182.
  12. Cosci F, Chouinard G, Chouinard V-A, Fava GA: The Diagnostic Clinical Interview for Drug Withdrawal 1 (DID-W1) -new symp- toms of selective serotonin reuptake inhibi- tors (SSRI) or serotonin noradrenaline reup- take inhibitors (SNRI): inter-rater reliability. Riv Psichiatr 2018; 53: 95-99.
  13. Chouinard G, Samaha AN, Chouinard V-A, Peretti C-S, Kanahara N, Takase M, Iyo M: Antipsychotic-induced dopamine supersen- sitivity psychosis. Psychother Psychosom 2017; 86: 189-219.
  14. Pollack MH, Van Ameringen M, Simon N, Worthinton JW, Hoge EA, Keshaviah A, Stein MB: A double-blind randomized controlled trial of augmentation and switch strategies for refractory social anxiety disorder. Am J Psy- chiatry 2014; 171: 44-53.
  15. Cloos JM, Bocquet V, Rolland-Portal I, Koch P, Chouinard G: Hypnotics and triazoloben- zodiazepines -best predictors of high-dose benzodiazepine use. Psychother Psychosom 2015; 84: 273-283.
  16. Fava GA, Sonino N: Depression associated with medical illness. CNS Drugs 1996; 5: 175- 189.
  17. Spina E, Trifirò G, Caraci F: Clinically signif- icant drug interactions with newer antide- pressants. CNS Drugs 2012; 26: 39-67.
  18. Fava GA, Grandi S, Rafanelli C, Fabbri S, Ca- zzaro M: Explanatory therapy in hypochon- driasis. J Clin Psychiatry 2000; 61: 317-322.
  19. Marks IM: Fears, Phobias and Rituals. New York, Oxford University Press, 1987.
  20. Sonino N, Fava GA: A simple instrument for assessing stress in clinical practice. Postgrad Med J 1998; 74: 408-410.
  21. Offidani E, Guidi J, Tomba E, Fava GA: Effi- cacy and tolerability of benzodiazepines ver- sus antidepressants in anxiety disorders. Psy- chother Psychosom 2013; 82: 355-362.
  22. Benasi G, Guidi J, Offidani E, Balon R, Rickels K, Fava GA: Benzodiazepines as a monother- apy in depressive disorders: a systematic re- view. Psychother Psychosom 2018; 87: 65-74.
  23. Jorgensen MB, Osler M: Should benzodiaze- pines be avoided? Acta Psychiatr Scand 2018; 138: 89-90.
  24. Tomba E, Guidi J, Fava GA: What psycholo- gists need to know about psychotropic medi- cations. Clin Psychol Psychother 2018; 25: 181-187.
  25. Baldessarini RJ, Ghaemi SN, Viguera AC: Tolerance in antidepressant treatment. Psy- chother Psychosom 2002; 71: 177-179.

Cited by

Sorted by citations

Authors
Fava, G. A., & Belaise, C.
Affiliations
  • University at Buffalo, State University of New York (US)
  • University of Bologna (IT)
Venue
Psychotherapy and Psychosomatics
Publisher
S. Karger AG
Published
2018
Volume
87
Issue
5
Pages
257-267
ISSN
  • 0033-3190 (ISSN-L)
  • 1423-0348
OpenAlex
W2889187894
Cited by
77
References
56
Citations by year
2026: 3 · 2025: 5 · 2024: 13 · 2023: 7 · 2022: 9 · 2021: 8 · 2020: 17 · 2019: 15
FWCI
6.49
Type
journal article
Language
en
Open access
Locations
  • Psychotherapy and Psychosomatics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
  • Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Keywords
antidepressant discontinuation, depression treatment, clinical experience
MeSH terms
Antidepressive Agents, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review